Once versus twice daily direct oral anticoagulants in patients with recent stroke and atrial fibrillation Article Swipe
Alexandros A. Polymeris
,
Annaelle Zietz
,
Fabian Schaub
,
Louisa Meya
,
Christopher Traenka
,
Sebastian Thilemann
,
Benjamin Wagner
,
Lisa Hert
,
Valerian Altersberger
,
David Seiffge
,
Flurina Lyrer
,
Tolga Dittrich
,
Ines Piot
,
Josefin E. Kaufmann
,
Lea Barone
,
Ludvig Dahlheim
,
Sophie Flammer
,
Nikolaos S. Avramiotis
,
Nils Peters
,
Gian Marco De Marchis
,
Leo H. Bonati
,
Henrik Gensicke
,
Stefan T. Engelter
,
Philippe Lyrer
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1177/23969873221099477
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1177/23969873221099477
Background: Data on the safety and effectiveness of once-daily (QD) versus twice-daily (BID) direct oral anticoagulants (DOAC) in comparison to vitamin K antagonists (VKA) and to one another in patients with atrial fibrillation (AF) and recent stroke are scarce. Patients and methods: Based on prospectively obtained data from the observational registry Novel-Oral-Anticoagulants-in-Ischemic-Stroke-Patients(NOACISP)-LONGTERM (NCT03826927) from Basel, Switzerland, we compared the occurrence of the primary outcome – the composite of recurrent ischemic stroke, major bleeding, and all-cause death – among consecutive AF patients treated with either VKA, QD DOAC, or BID DOAC following a recent stroke using Cox proportional hazards regression including adjustment for potential confounders. Results: We analyzed 956 patients (median age 80 years, 46% female), of whom 128 received VKA (13.4%), 264 QD DOAC (27.6%), and 564 BID DOAC (59%). Over a total follow-up of 1596 patient-years, both QD DOAC and BID DOAC showed a lower hazard for the composite outcome compared to VKA (adjusted HR [95% CI] 0.69 [0.48, 1.01] and 0.66 [0.47, 0.91], respectively). Upon direct comparison, the hazard for the composite outcome did not differ between patients treated with QD versus BID DOAC (adjusted HR [95% CI] 0.94 [0.70, 1.26]). Secondary analyses focusing on the individual components of the composite outcome revealed no clear differences in the risk-benefit profile of QD versus BID DOAC. Discussion and conclusion: The overall benefit of DOAC over VKA seems to apply to both QD and BID DOAC in AF patients with a recent stroke, without clear evidence that one DOAC dosing regimen is more advantageous than the other.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1177/23969873221099477
- https://journals.sagepub.com/doi/pdf/10.1177/23969873221099477
- OA Status
- bronze
- Cited By
- 6
- References
- 40
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4280509412
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4280509412Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1177/23969873221099477Digital Object Identifier
- Title
-
Once versus twice daily direct oral anticoagulants in patients with recent stroke and atrial fibrillationWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-05-10Full publication date if available
- Authors
-
Alexandros A. Polymeris, Annaelle Zietz, Fabian Schaub, Louisa Meya, Christopher Traenka, Sebastian Thilemann, Benjamin Wagner, Lisa Hert, Valerian Altersberger, David Seiffge, Flurina Lyrer, Tolga Dittrich, Ines Piot, Josefin E. Kaufmann, Lea Barone, Ludvig Dahlheim, Sophie Flammer, Nikolaos S. Avramiotis, Nils Peters, Gian Marco De Marchis, Leo H. Bonati, Henrik Gensicke, Stefan T. Engelter, Philippe LyrerList of authors in order
- Landing page
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https://doi.org/10.1177/23969873221099477Publisher landing page
- PDF URL
-
https://journals.sagepub.com/doi/pdf/10.1177/23969873221099477Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
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https://journals.sagepub.com/doi/pdf/10.1177/23969873221099477Direct OA link when available
- Concepts
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Medicine, Atrial fibrillation, Hazard ratio, Stroke (engine), Internal medicine, Confounding, Proportional hazards model, Observational study, Cardiology, Confidence interval, Mechanical engineering, EngineeringTop concepts (fields/topics) attached by OpenAlex
- Cited by
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6Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2, 2024: 3, 2023: 1Per-year citation counts (last 5 years)
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40Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.either | 83 |
| abstract_inverted_index.hazard | 146, 170 |
| abstract_inverted_index.other. | 256 |
| abstract_inverted_index.recent | 35, 92, 241 |
| abstract_inverted_index.safety | 4 |
| abstract_inverted_index.showed | 143 |
| abstract_inverted_index.stroke | 36, 93 |
| abstract_inverted_index.versus | 10, 183, 214 |
| abstract_inverted_index.years, | 112 |
| abstract_inverted_index.(median | 109 |
| abstract_inverted_index.1.26]). | 192 |
| abstract_inverted_index.another | 27 |
| abstract_inverted_index.benefit | 222 |
| abstract_inverted_index.between | 178 |
| abstract_inverted_index.hazards | 97 |
| abstract_inverted_index.outcome | 63, 150, 174, 203 |
| abstract_inverted_index.overall | 221 |
| abstract_inverted_index.primary | 62 |
| abstract_inverted_index.profile | 211 |
| abstract_inverted_index.regimen | 250 |
| abstract_inverted_index.scarce. | 38 |
| abstract_inverted_index.stroke, | 70, 242 |
| abstract_inverted_index.treated | 81, 180 |
| abstract_inverted_index.vitamin | 20 |
| abstract_inverted_index.without | 243 |
| abstract_inverted_index.(13.4%), | 120 |
| abstract_inverted_index.(27.6%), | 124 |
| abstract_inverted_index.Patients | 39 |
| abstract_inverted_index.Results: | 104 |
| abstract_inverted_index.analyses | 194 |
| abstract_inverted_index.analyzed | 106 |
| abstract_inverted_index.compared | 57, 151 |
| abstract_inverted_index.evidence | 245 |
| abstract_inverted_index.female), | 114 |
| abstract_inverted_index.focusing | 195 |
| abstract_inverted_index.ischemic | 69 |
| abstract_inverted_index.methods: | 41 |
| abstract_inverted_index.obtained | 45 |
| abstract_inverted_index.patients | 29, 80, 108, 179, 238 |
| abstract_inverted_index.received | 118 |
| abstract_inverted_index.registry | 50 |
| abstract_inverted_index.revealed | 204 |
| abstract_inverted_index.(adjusted | 154, 186 |
| abstract_inverted_index.Secondary | 193 |
| abstract_inverted_index.all-cause | 74 |
| abstract_inverted_index.bleeding, | 72 |
| abstract_inverted_index.composite | 66, 149, 173, 202 |
| abstract_inverted_index.follow-up | 133 |
| abstract_inverted_index.following | 90 |
| abstract_inverted_index.including | 99 |
| abstract_inverted_index.potential | 102 |
| abstract_inverted_index.recurrent | 68 |
| abstract_inverted_index.Discussion | 217 |
| abstract_inverted_index.adjustment | 100 |
| abstract_inverted_index.comparison | 18 |
| abstract_inverted_index.components | 199 |
| abstract_inverted_index.individual | 198 |
| abstract_inverted_index.occurrence | 59 |
| abstract_inverted_index.once-daily | 8 |
| abstract_inverted_index.regression | 98 |
| abstract_inverted_index.Background: | 0 |
| abstract_inverted_index.antagonists | 22 |
| abstract_inverted_index.comparison, | 168 |
| abstract_inverted_index.conclusion: | 219 |
| abstract_inverted_index.consecutive | 78 |
| abstract_inverted_index.differences | 207 |
| abstract_inverted_index.twice-daily | 11 |
| abstract_inverted_index.Switzerland, | 55 |
| abstract_inverted_index.advantageous | 253 |
| abstract_inverted_index.confounders. | 103 |
| abstract_inverted_index.fibrillation | 32 |
| abstract_inverted_index.proportional | 96 |
| abstract_inverted_index.risk-benefit | 210 |
| abstract_inverted_index.(NCT03826927) | 52 |
| abstract_inverted_index.effectiveness | 6 |
| abstract_inverted_index.observational | 49 |
| abstract_inverted_index.prospectively | 44 |
| abstract_inverted_index.anticoagulants | 15 |
| abstract_inverted_index.patient-years, | 136 |
| abstract_inverted_index.respectively). | 165 |
| abstract_inverted_index.Novel-Oral-Anticoagulants-in-Ischemic-Stroke-Patients(NOACISP)-LONGTERM | 51 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5034038759, https://openalex.org/A5007119825 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 24 |
| corresponding_institution_ids | https://openalex.org/I1850255, https://openalex.org/I2802542264, https://openalex.org/I4210115885 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8199999928474426 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.77215666 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |