Oncogenic role of MiR-130a in oral squamous cell carcinoma Article Swipe
Karthik Mallela
,
Shivananda Swamy
,
K. S. Gopinath
,
Arun Kumar
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1038/s41598-021-87388-4
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1038/s41598-021-87388-4
Aberrant activation of the PI3K/AKT/mTOR pathway is attributed to the pathogenesis of oral squamous cell carcinoma (OSCC). In recent years, increasing evidence suggests the involvement of microRNAs (miRNAs) in oral carcinogenesis by acting as tumor suppressors or oncogenes. TSC1, as a component of the above pathway, regulates several cellular functions such as cell proliferation, apoptosis, migration and invasion. Downregulation of TSC1 is reported in oral as well as several other cancers and is associated with an unfavourable clinical outcome in patients. Here we show that oncogenic miR-130a binds to the 3′UTR of TSC1 and represses its expression. MiR-130a-mediated repression of TSC1 increases cell proliferation, anchorage independent growth and invasion of OSCC cells, which is dependent on the presence of the 3′UTR in TSC1. We observe an inverse correlation between the expression levels of miR-130a and TSC1 in OSCC samples, suggesting that their interaction is physiologically relevant. Delivery of antagomiR-130a to OSCC cells results in a significant decrease in xenograft size. Taken together, the findings of the study indicate that miR-130a-mediated TSC1 downregulation is not only a novel mechanism in OSCC, but also the restoration of TSC1 levels by antagomiR-130a may be a potential therapeutic strategy for the treatment of OSCC.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41598-021-87388-4
- https://www.nature.com/articles/s41598-021-87388-4.pdf
- OA Status
- gold
- Cited By
- 16
- References
- 52
- Related Works
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- OpenAlex ID
- https://openalex.org/W3151735683
All OpenAlex metadata
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https://openalex.org/W3151735683Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1038/s41598-021-87388-4Digital Object Identifier
- Title
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Oncogenic role of MiR-130a in oral squamous cell carcinomaWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-04-08Full publication date if available
- Authors
-
Karthik Mallela, Shivananda Swamy, K. S. Gopinath, Arun KumarList of authors in order
- Landing page
-
https://doi.org/10.1038/s41598-021-87388-4Publisher landing page
- PDF URL
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https://www.nature.com/articles/s41598-021-87388-4.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
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-
goldOpen access status per OpenAlex
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https://www.nature.com/articles/s41598-021-87388-4.pdfDirect OA link when available
- Concepts
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Basal cell, Cancer research, Oral Cancers, Medicine, Oncology, Biology, Internal medicineTop concepts (fields/topics) attached by OpenAlex
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16Total citation count in OpenAlex
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2025: 2, 2024: 5, 2023: 6, 2022: 3Per-year citation counts (last 5 years)
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52Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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