Oncologic and Functional Outcomes of T3 Glottic Squamous Cell Carcinoma Following Transoral Laser Microsurgery: A Retrospective Chart Review Article Swipe
YOU?
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· 2025
· Open Access
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· DOI: https://doi.org/10.1177/19160216251385930
Importance Few centers globally use transoral laser microsurgery (TLM) for primary treatment of T3 glottic squamous cell carcinoma (SCC); consequently, data on its use in this setting are sparse. Objective The aim of this study was to evaluate the oncologic and functional outcomes in T3 glottic SCC following TLM, including the impact of anterior commissure (AC) involvement. Design Retrospective chart review. Setting Single Canadian tertiary care hospital in Halifax, Nova Scotia, from January 2006 to December 2021. Participants Adult (>18 years old) patients with T3 glottic SCC treated with TLM. Patients were excluded if they were previously treated for laryngeal cancer. Intervention or Exposures This study used prospectively collected data for patients treated with TLM for T3 glottic SCC. Main Outcome Measures Oncologic outcomes were assessed using disease-specific survival (DSS), local control (LC), and laryngectomy-free survival (LFS). Functional outcomes were measured using the Voice Handicap Index-10 (VHI-10). Results In total, 28 patients (mean age = 68.4 years) underwent curative TLM for T3 glottic SCC. Sixteen of the cases involved the AC and 22 had paraglottic space involvement. Two and 5-year DSS were 79.2% (CI = 62.3%-100%). Two and 5-year LC were 80.2% (CI = 65.9%-97.4%) and 52.6% (CI = 27.4%-100%), respectively, and 2- and 5-year LFS rates were 86.1% (CI = 72.6%-100%) and 64.6% (CI = 35.8%-100%). AC involvement had no significant impact on DSS, LC, or LFS. There was no significant difference in preoperative and 3-month VHI-10 scores ( P = .6632); however, there was significant improvement noted at the 6 ( P = .042) and 12-month ( P = .037) periods. Conclusions TLM is a viable surgical option for appropriately selected patients with T3 glottic SCC, with or without AC involvement, achieving favorable oncologic and functional outcomes. Relevance These findings further contribute to the limited evidence supporting the use of TLM in the management of advanced-stage glottic cancer.
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- Type
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- https://doi.org/10.1177/19160216251385930
- OA Status
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Raw OpenAlex JSON
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https://openalex.org/W4415463587Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1177/19160216251385930Digital Object Identifier
- Title
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Oncologic and Functional Outcomes of T3 Glottic Squamous Cell Carcinoma Following Transoral Laser Microsurgery: A Retrospective Chart ReviewWork title
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articleOpenAlex work type
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enPrimary language
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2025Year of publication
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2025-10-01Full publication date if available
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Victoria Taylor, Emma Bogner, Jessica Henley, Colin MacKay, Matthew H. Rigby, Martin Corsten, Jonathan Trites, Mark TaylorList of authors in order
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https://doi.org/10.1177/19160216251385930Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1177/19160216251385930Direct OA link when available
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0Total citation count in OpenAlex
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25Number of works referenced by this work
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