Oncological and renal function outcome in children with unilateral wilms' tumors treated with nephron sparing surgery or ablative nephrectomy Article Swipe
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· 2020
· Open Access
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· DOI: https://doi.org/10.4103/jcrp.jcrp_12_20
Background: We prospectively evaluated the oncological and renal functional outcomes of children with unilateral Wilms' tumor (WT) undergoing nephron-sparing surgery (NSS) versus ablative nephrectomy. Materials and Methods: Children presenting with unilateral WT from January 2006 to December 2015 were prospectively randomized to undergo either ablative (simple/radical) nephrectomy or NSS. Treatment was administered according to the Societe Internationale d'Oncologie Pediatrique-2001 protocol. Results: During the 10-year study period, 13 children underwent ablative nephrectomy, and 15 underwent NSS (partial nephrectomy/wedge excision). The contralateral kidneys were found to be normal on ultrasonography and computed tomography imaging. The mean age at intervention was 44.8 ± 16.7 months. Eight children presented with Stage I disease and the remaining 20 had Stage II disease. The mean follow-up period was 53. 68 ± 23.82 months and all children were alive at the last follow-up without any clinical evidence of disease. The event-free survival rates were 100% and 92.3% in the children undergoing NSS and ablative nephrectomy, respectively. The children who underwent ablative nephrectomy presented with considerably higher mean systolic and diastolic blood pressures, as well as significantly elevated mean values of serum creatinine compared to their ablative nephrectomy counterparts. Conclusion: The oncological outcome of NSS was as good as ablative nephrectomy in children with unilateral WTs. NSS also minimized the loss of renal function.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.4103/jcrp.jcrp_12_20
- OA Status
- diamond
- Cited By
- 3
- References
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- OpenAlex ID
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Raw OpenAlex JSON
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https://openalex.org/W3082585675Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.4103/jcrp.jcrp_12_20Digital Object Identifier
- Title
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Oncological and renal function outcome in children with unilateral wilms' tumors treated with nephron sparing surgery or ablative nephrectomyWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-01-01Full publication date if available
- Authors
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Rajendra B. Nerli, Manas Sharma, ShridharC Ghagane, Sreeharsha Nutalapati, Murigendra B. Hiremath, NeerajS DixitList of authors in order
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https://doi.org/10.4103/jcrp.jcrp_12_20Publisher landing page
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YesWhether a free full text is available
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diamondOpen access status per OpenAlex
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https://doi.org/10.4103/jcrp.jcrp_12_20Direct OA link when available
- Concepts
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Medicine, Nephrectomy, Ablative case, Surgery, Renal function, Kidney disease, Stage (stratigraphy), Kidney, Wilms' tumor, Radiation therapy, Internal medicine, Paleontology, BiologyTop concepts (fields/topics) attached by OpenAlex
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3Total citation count in OpenAlex
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2023: 1, 2022: 2Per-year citation counts (last 5 years)
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23Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| referenced_works | https://openalex.org/W2018163419, https://openalex.org/W1985577912, https://openalex.org/W2009622908, https://openalex.org/W1980485503, https://openalex.org/W6797784697, https://openalex.org/W2002201247, https://openalex.org/W2027026910, https://openalex.org/W1972769091, https://openalex.org/W2020677308, https://openalex.org/W2085432680, https://openalex.org/W2102063016, https://openalex.org/W1994176086, https://openalex.org/W6716488962, https://openalex.org/W2021045121, https://openalex.org/W1082201789, https://openalex.org/W2052029867, https://openalex.org/W6693186124, https://openalex.org/W2006473120, https://openalex.org/W2113374072, https://openalex.org/W2883898586, https://openalex.org/W2262420475, https://openalex.org/W3175313800, https://openalex.org/W2416868758 |
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