Onset and progression of postmortem histological changes in the central nervous system of RccHan™: WIST rats Article Swipe
Klaus Weber
,
Anna Domènech
,
Kristel Kegler
,
Robert Kreutzer
,
Francisco José Mayoral
,
Yoshimasa Okazaki
,
Paula Ortega
,
Laura Polledo
,
Tanja Razinger
,
Olivia K. Richard
,
Raúl Sánchez Jurado
,
Nils Warfving
,
Raquel Vallejo
,
Ricardo de Miguel
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fvets.2024.1378609
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fvets.2024.1378609
Death initiates a cascade of physiological and biochemical alterations in organs and tissues, resulting in microscopic changes that challenge the histopathological evaluation. Moreover, the brain is particularly susceptible to artifacts owing to its unique composition and its location within the cranial vault. The aim of this study was to compile and illustrate the microscopic changes in the central nervous system (CNS) of rats subjected to delayed postmortem fixation. It also scrutinizes the influence of exsanguination and cooling methods on the initiation and progression of these alterations. Twenty-four Wistar Han outbred rats (RccHan ™ : WIST) were sacrificed and stored either at room temperature (18–22°C) or under refrigeration (2–4°C). Necropsies were conducted at different time points postmortem (i.e., 0.5 h, 1 h, 4 h, 8 h, 12 h, 24 h, 36 h, 48 h, 7 days and 14 days). Brain sections underwent simultaneous digital evaluation by 14 pathologists until a consensus was reached on terminology, key findings, and intensity levels. Microscopic observations varied among cell types. Glial cells were similarly affected throughout the CNS and showed pericellular halo, chromatin condensation and nuclear shrinkage. Neurons showed two types of postmortem changes as most of them showed progressive shrinkage, cytoplasmic dissolution and karyorrhexis whereas others acquired a dark-neuron-like appearance. Neuronal changes showed marked differences among neuroanatomical locations. Additional postmortem changes encompassed: granulation and microcavitation in neuropil and white matter; retraction spaces; detachment of ependyma, choroid plexus, and leptomeninges. Severity of findings after 48 h at room temperature was higher than after seven days under refrigeration and similar to or slightly lower than after 14 days under refrigeration. No clear differences were observed related to the sex or weight of the animals or their exsanguination status. This work elucidates the onset and progression of autolytic changes in the brains of Wistar Han rats, offering insights to accurately identify and enhance the histopathological evaluation.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fvets.2024.1378609
- https://www.frontiersin.org/articles/10.3389/fvets.2024.1378609/pdf?isPublishedV2=False
- OA Status
- gold
- Cited By
- 1
- References
- 58
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4398169047
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4398169047Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fvets.2024.1378609Digital Object Identifier
- Title
-
Onset and progression of postmortem histological changes in the central nervous system of RccHan™: WIST ratsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-05-21Full publication date if available
- Authors
-
Klaus Weber, Anna Domènech, Kristel Kegler, Robert Kreutzer, Francisco José Mayoral, Yoshimasa Okazaki, Paula Ortega, Laura Polledo, Tanja Razinger, Olivia K. Richard, Raúl Sánchez Jurado, Nils Warfving, Raquel Vallejo, Ricardo de MiguelList of authors in order
- Landing page
-
https://doi.org/10.3389/fvets.2024.1378609Publisher landing page
- PDF URL
-
https://www.frontiersin.org/articles/10.3389/fvets.2024.1378609/pdf?isPublishedV2=FalseDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.frontiersin.org/articles/10.3389/fvets.2024.1378609/pdf?isPublishedV2=FalseDirect OA link when available
- Concepts
-
Central nervous system, Biology, Pathology, Postmortem studies, Anatomy, Postmortem Changes, Medicine, Physiology, NeuroscienceTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1Per-year citation counts (last 5 years)
- References (count)
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58Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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