Optical coherence tomography assessment of the impact of colchicine on non-culprit coronary plaque composition after myocardial infarction Article Swipe
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· 2024
· Open Access
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· DOI: https://doi.org/10.1093/cvr/cvae191
Aims Low-dose colchicine reduces the risk of cardiovascular events after myocardial infarction (MI). The purpose of this study was to assess the effect of colchicine post-MI on coronary plaque morphology in non-culprit segments by optical coherence tomography (OCT). Methods and results COCOMO-ACS was a double-blind, placebo-controlled trial that randomized 64 patients (median age 61.5 years; 9.4% female) with acute non-ST-segment elevation MI to colchicine 0.5 mg daily or placebo for a median of 17.8 months in addition to guideline-recommended therapy. Participants underwent serial OCT imaging within a matched segment of non-culprit coronary artery that contained at least one lipid-rich plaque causing ≥20% stenosis. The primary outcome was the change in minimum fibrous cap thickness (FCT) in non-culprit segments from baseline to final visit. Of those randomized, 57 (29 placebo, 28 colchicine) had evaluable imaging at baseline and follow-up. Overall, colchicine had no effect on relative (placebo +48.0 ± 35.1% vs. colchicine +62.4 ± 38.1%, P = 0.18) or absolute changes in minimum FCT (+29.2 ± 20.9 µm vs. + 37.2 ± 21.3 µm, P = 0.18), or change in maximum lipid arc (−38.8 ± 32.2° vs. −54.8 ± 46.9°, P = 0.18) throughout the imaged non-culprit segment. However, in patients assigned colchicine, cap rupture was less frequent (placebo 27.6% vs. colchicine 3.6%, P = 0.03). In post hoc analysis of 43 participants who had been followed for at least 16 months, minimum FCT increased to a greater extent in the colchicine group (placebo +38.7 ± 25.4% vs. colchicine +64.7 ± 34.1%, P = 0.005). Conclusion In this study, OCT failed to detect an effect of colchicine on the minimum FCT or maximum lipid arc of plaques in non-culprit segments post-MI. The post hoc observation that minimum FCT increased to a greater extent with colchicine after more prolonged treatment suggests that longer-term studies may be required to detect the effect of anti-inflammatory therapies on plaque morphology by OCT. Clinical trial number Australian New Zealand Clinical Trials Registry Identifier, ACTRN12618000809235, registered on the 11 May 2018.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/cvr/cvae191
- https://academic.oup.com/cardiovascres/advance-article-pdf/doi/10.1093/cvr/cvae191/58933719/cvae191.pdf
- OA Status
- bronze
- Cited By
- 24
- References
- 36
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4401915781
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4401915781Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1093/cvr/cvae191Digital Object Identifier
- Title
-
Optical coherence tomography assessment of the impact of colchicine on non-culprit coronary plaque composition after myocardial infarctionWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-08-27Full publication date if available
- Authors
-
Peter J. Psaltis, Mau T. Nguyen, Kuljit Singh, A. Sinhal, Dennis Wong, Richard Alcock, S Rajendran, Rustem Dautov, Peter Barlis, Sanjay Patel, Thalia Salagaras, J. Marathe, Christina A. Bursill, Nicholas J. Montarello, Stefan M. Nidorf, Peter L. Thompson, Julie Butters, Alana R. Cuthbert, Lisa N Yelland, Juanita L. Ottaway, Yu Kataoka, Giuseppe Di Giovanni, Stephen J NichollsList of authors in order
- Landing page
-
https://doi.org/10.1093/cvr/cvae191Publisher landing page
- PDF URL
-
https://academic.oup.com/cardiovascres/advance-article-pdf/doi/10.1093/cvr/cvae191/58933719/cvae191.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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bronzeOpen access status per OpenAlex
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https://academic.oup.com/cardiovascres/advance-article-pdf/doi/10.1093/cvr/cvae191/58933719/cvae191.pdfDirect OA link when available
- Concepts
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Medicine, Myocardial infarction, Cardiology, Culprit, Optical coherence tomography, Internal medicine, RadiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
24Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 21, 2024: 3Per-year citation counts (last 5 years)
- References (count)
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36Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.change | 109, 178 |
| abstract_inverted_index.detect | 262, 307 |
| abstract_inverted_index.effect | 23, 143, 264, 309 |
| abstract_inverted_index.events | 9 |
| abstract_inverted_index.extent | 238, 292 |
| abstract_inverted_index.failed | 260 |
| abstract_inverted_index.imaged | 195 |
| abstract_inverted_index.median | 72 |
| abstract_inverted_index.months | 75 |
| abstract_inverted_index.number | 320 |
| abstract_inverted_index.plaque | 29, 100, 314 |
| abstract_inverted_index.serial | 83 |
| abstract_inverted_index.study, | 258 |
| abstract_inverted_index.visit. | 123 |
| abstract_inverted_index.within | 86 |
| abstract_inverted_index.years; | 55 |
| abstract_inverted_index.≥20% | 102 |
| abstract_inverted_index.(median | 52 |
| abstract_inverted_index.0.005). | 254 |
| abstract_inverted_index.46.9°, | 189 |
| abstract_inverted_index.Methods | 39 |
| abstract_inverted_index.Zealand | 323 |
| abstract_inverted_index.causing | 101 |
| abstract_inverted_index.changes | 160 |
| abstract_inverted_index.female) | 57 |
| abstract_inverted_index.fibrous | 112 |
| abstract_inverted_index.greater | 237, 291 |
| abstract_inverted_index.imaging | 85, 134 |
| abstract_inverted_index.matched | 88 |
| abstract_inverted_index.maximum | 180, 272 |
| abstract_inverted_index.minimum | 111, 162, 232, 269, 286 |
| abstract_inverted_index.months, | 231 |
| abstract_inverted_index.optical | 35 |
| abstract_inverted_index.outcome | 106 |
| abstract_inverted_index.placebo | 69 |
| abstract_inverted_index.plaques | 276 |
| abstract_inverted_index.post-MI | 26 |
| abstract_inverted_index.primary | 105 |
| abstract_inverted_index.purpose | 15 |
| abstract_inverted_index.reduces | 4 |
| abstract_inverted_index.results | 41 |
| abstract_inverted_index.rupture | 204 |
| abstract_inverted_index.segment | 89 |
| abstract_inverted_index.studies | 302 |
| abstract_inverted_index.−54.8 | 187 |
| abstract_inverted_index.(placebo | 146, 208, 243 |
| abstract_inverted_index.(−38.8 | 183 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.Clinical | 318, 324 |
| abstract_inverted_index.However, | 198 |
| abstract_inverted_index.Low-dose | 2 |
| abstract_inverted_index.Overall, | 139 |
| abstract_inverted_index.Registry | 326 |
| abstract_inverted_index.absolute | 159 |
| abstract_inverted_index.addition | 77 |
| abstract_inverted_index.analysis | 219 |
| abstract_inverted_index.assigned | 201 |
| abstract_inverted_index.baseline | 120, 136 |
| abstract_inverted_index.coronary | 28, 92 |
| abstract_inverted_index.followed | 226 |
| abstract_inverted_index.frequent | 207 |
| abstract_inverted_index.patients | 51, 200 |
| abstract_inverted_index.placebo, | 129 |
| abstract_inverted_index.post-MI. | 280 |
| abstract_inverted_index.relative | 145 |
| abstract_inverted_index.required | 305 |
| abstract_inverted_index.segment. | 197 |
| abstract_inverted_index.segments | 33, 118, 279 |
| abstract_inverted_index.suggests | 299 |
| abstract_inverted_index.therapy. | 80 |
| abstract_inverted_index.coherence | 36 |
| abstract_inverted_index.contained | 95 |
| abstract_inverted_index.elevation | 61 |
| abstract_inverted_index.evaluable | 133 |
| abstract_inverted_index.increased | 234, 288 |
| abstract_inverted_index.prolonged | 297 |
| abstract_inverted_index.stenosis. | 103 |
| abstract_inverted_index.therapies | 312 |
| abstract_inverted_index.thickness | 114 |
| abstract_inverted_index.treatment | 298 |
| abstract_inverted_index.underwent | 82 |
| abstract_inverted_index.Australian | 321 |
| abstract_inverted_index.COCOMO-ACS | 42 |
| abstract_inverted_index.Conclusion | 255 |
| abstract_inverted_index.colchicine | 3, 25, 64, 140, 151, 211, 241, 248, 266, 294 |
| abstract_inverted_index.follow-up. | 138 |
| abstract_inverted_index.infarction | 12 |
| abstract_inverted_index.lipid-rich | 99 |
| abstract_inverted_index.morphology | 30, 315 |
| abstract_inverted_index.myocardial | 11 |
| abstract_inverted_index.randomized | 49 |
| abstract_inverted_index.registered | 329 |
| abstract_inverted_index.throughout | 193 |
| abstract_inverted_index.tomography | 37 |
| abstract_inverted_index.Identifier, | 327 |
| abstract_inverted_index.colchicine) | 131 |
| abstract_inverted_index.colchicine, | 202 |
| abstract_inverted_index.longer-term | 301 |
| abstract_inverted_index.non-culprit | 32, 91, 117, 196, 278 |
| abstract_inverted_index.observation | 284 |
| abstract_inverted_index.randomized, | 126 |
| abstract_inverted_index.Participants | 81 |
| abstract_inverted_index.participants | 222 |
| abstract_inverted_index.double-blind, | 45 |
| abstract_inverted_index.cardiovascular | 8 |
| abstract_inverted_index.non-ST-segment | 60 |
| abstract_inverted_index.anti-inflammatory | 311 |
| abstract_inverted_index.placebo-controlled | 46 |
| abstract_inverted_index.ACTRN12618000809235, | 328 |
| abstract_inverted_index.guideline-recommended | 79 |
| cited_by_percentile_year.max | 100 |
| cited_by_percentile_year.min | 96 |
| corresponding_author_ids | https://openalex.org/A5005228563 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 23 |
| corresponding_institution_ids | https://openalex.org/I4210100798, https://openalex.org/I4210137740, https://openalex.org/I4392738059, https://openalex.org/I5681781 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8299999833106995 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.99620715 |
| citation_normalized_percentile.is_in_top_1_percent | True |
| citation_normalized_percentile.is_in_top_10_percent | True |