Optical Investigation of Action Potential and Calcium Handling Maturation of hiPSC-Cardiomyocytes on Biomimetic Substrates Article Swipe
Josè Manuel Pioner
,
Lorenzo Santini
,
Chiara Palandri
,
Daniele Martella
,
Flavia Lupi
,
Marianna Langione
,
Silvia Querceto
,
Bruno Grandinetti
,
Valentina Balducci
,
Patrizia Benzoni
,
Sara Landi
,
Andrea Barbuti
,
Federico Ferrarese Lupi
,
Luca Boarino
,
Laura Sartiani
,
Chiara Tesi
,
David L. Mack
,
Michael Regnier
,
Elisabetta Cerbai
,
Camilla Parmeggiani
,
Corrado Poggesi
,
Cecilia Ferrantini
,
Raffaele Coppini
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.3390/ijms20153799
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.3390/ijms20153799
Cardiomyocytes from human induced pluripotent stem cells (hiPSC-CMs) are the most promising human source with preserved genetic background of healthy individuals or patients. This study aimed to establish a systematic procedure for exploring development of hiPSC-CM functional output to predict genetic cardiomyopathy outcomes and identify molecular targets for therapy. Biomimetic substrates with microtopography and physiological stiffness can overcome the immaturity of hiPSC-CM function. We have developed a custom-made apparatus for simultaneous optical measurements of hiPSC-CM action potential and calcium transients to correlate these parameters at specific time points (day 60, 75 and 90 post differentiation) and under inotropic interventions. In later-stages, single hiPSC-CMs revealed prolonged action potential duration, increased calcium transient amplitude and shorter duration that closely resembled those of human adult cardiomyocytes from fresh ventricular tissue of patients. Thus, the major contribution of sarcoplasmic reticulum and positive inotropic response to β-adrenergic stimulation are time-dependent events underlying excitation contraction coupling (ECC) maturation of hiPSC-CM; biomimetic substrates can promote calcium-handling regulation towards adult-like kinetics. Simultaneous optical recordings of long-term cultured hiPSC-CMs on biomimetic substrates favor high-throughput electrophysiological analysis aimed at testing (mechanistic hypothesis on) disease progression and pharmacological interventions in patient-derived hiPSC-CMs.
Related Topics
Concepts
Calcium
Induced pluripotent stem cell
Stimulation
Inotrope
Biophysics
Chemistry
Cell biology
Internal medicine
Medicine
Biology
Pharmacology
Neuroscience
Biochemistry
Embryonic stem cell
Gene
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms20153799
- https://www.mdpi.com/1422-0067/20/15/3799/pdf?version=1564825405
- OA Status
- gold
- Cited By
- 41
- References
- 33
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2965294564
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2965294564Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/ijms20153799Digital Object Identifier
- Title
-
Optical Investigation of Action Potential and Calcium Handling Maturation of hiPSC-Cardiomyocytes on Biomimetic SubstratesWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2019Year of publication
- Publication date
-
2019-08-03Full publication date if available
- Authors
-
Josè Manuel Pioner, Lorenzo Santini, Chiara Palandri, Daniele Martella, Flavia Lupi, Marianna Langione, Silvia Querceto, Bruno Grandinetti, Valentina Balducci, Patrizia Benzoni, Sara Landi, Andrea Barbuti, Federico Ferrarese Lupi, Luca Boarino, Laura Sartiani, Chiara Tesi, David L. Mack, Michael Regnier, Elisabetta Cerbai, Camilla Parmeggiani, Corrado Poggesi, Cecilia Ferrantini, Raffaele CoppiniList of authors in order
- Landing page
-
https://doi.org/10.3390/ijms20153799Publisher landing page
- PDF URL
-
https://www.mdpi.com/1422-0067/20/15/3799/pdf?version=1564825405Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1422-0067/20/15/3799/pdf?version=1564825405Direct OA link when available
- Concepts
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Calcium, Induced pluripotent stem cell, Stimulation, Inotrope, Biophysics, Chemistry, Cell biology, Internal medicine, Medicine, Biology, Pharmacology, Neuroscience, Biochemistry, Embryonic stem cell, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
41Total citation count in OpenAlex
- Citations by year (recent)
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2025: 4, 2024: 9, 2023: 5, 2022: 7, 2021: 9Per-year citation counts (last 5 years)
- References (count)
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33Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.cardiomyocytes | 122 |
| abstract_inverted_index.cardiomyopathy | 41 |
| abstract_inverted_index.interventions. | 98 |
| abstract_inverted_index.time-dependent | 144 |
| abstract_inverted_index.high-throughput | 174 |
| abstract_inverted_index.microtopography | 52 |
| abstract_inverted_index.patient-derived | 189 |
| abstract_inverted_index.pharmacological | 186 |
| abstract_inverted_index.calcium-handling | 158 |
| abstract_inverted_index.differentiation) | 94 |
| abstract_inverted_index.electrophysiological | 175 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 97 |
| corresponding_author_ids | https://openalex.org/A5048771701, https://openalex.org/A5059236440 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 23 |
| corresponding_institution_ids | https://openalex.org/I45084792 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.5799999833106995 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.89715866 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |