Optimization of HPLC method for determination of cefixime using 2-thiophenecarboxaldehyde as derivatizing reagent: A new approach Article Swipe
Madan Lal Maheshwari
,
Ayaz Ali Memon
,
Shahabuddin Memon
,
Fakhar-un-Nisa Memon
,
Ubed Ur Rahman Mughal
,
Abdullah Dayo
,
Naheed Memon
,
Mohammed Ali Ghoto
,
M.K. Leghari
·
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1016/j.jsps.2015.01.016
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1016/j.jsps.2015.01.016
The determination of cefixime 1 has clinical and analytical importance due to its broad spectrum antimicrobial activity and stability. Cefixime is a significant member of orally active third generation cephalosporin and has excellent activity against many pathogens. It is for first time that we have developed a new HPLC-DAD method for analysis of imine derivative 3 of cefixime by using reflux method at 100 °C for 50 min without any buffer solution. 2 Thiophenecarboxaldehyde (2TCA) 2 was used first time as a derivatizing reagent for cefixime drug. Furthermore, separation of three components, i.e. drug (cefixime), reagent (2TCA) and derivative was carried out using kromasil 100 C-18 (15 mm × 0.46 mm, 5 μm) column with isocratic elution of methanol: 0.1% aqueous formic acid (70:30 v/v) with flow rate of 1 ml min(-) (1) at retention time of 1.8, 2.4 and 3.3 min, respectively; while, total run time was 5 min. The developed method was repeatable with a relative standard deviation (RSD) of 0.81-1.88% for imine derivative. The limit of detection and quantification of imine derivative 3 were obtained within the range of 0.132-0.401 μg ml(-) (1) and compared with cefixime drug as 0.30-0.90 μg ml(-1), respectively. However, the formation of imine derivative 3 was confirmed by comparing peak height, retention time and spectral changes. The method is rapid, simple, very stable and accurate for the separation and determination of imine derivative 3 of cefixime 1.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.jsps.2015.01.016
- OA Status
- hybrid
- Cited By
- 33
- References
- 41
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W1995312541
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W1995312541Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.jsps.2015.01.016Digital Object Identifier
- Title
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Optimization of HPLC method for determination of cefixime using 2-thiophenecarboxaldehyde as derivatizing reagent: A new approachWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2015Year of publication
- Publication date
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2015-01-16Full publication date if available
- Authors
-
Madan Lal Maheshwari, Ayaz Ali Memon, Shahabuddin Memon, Fakhar-un-Nisa Memon, Ubed Ur Rahman Mughal, Abdullah Dayo, Naheed Memon, Mohammed Ali Ghoto, M.K. LeghariList of authors in order
- Landing page
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https://doi.org/10.1016/j.jsps.2015.01.016Publisher landing page
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YesWhether a free full text is available
- OA status
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hybridOpen access status per OpenAlex
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https://doi.org/10.1016/j.jsps.2015.01.016Direct OA link when available
- Concepts
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Cefixime, Reagent, Chromatography, High-performance liquid chromatography, Chemistry, Organic chemistry, Biochemistry, Antibiotics, CephalosporinTop concepts (fields/topics) attached by OpenAlex
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33Total citation count in OpenAlex
- Citations by year (recent)
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2025: 5, 2024: 3, 2023: 2, 2022: 5, 2021: 3Per-year citation counts (last 5 years)
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41Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| primary_topic.display_name | Antibiotics Pharmacokinetics and Efficacy |
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