Optimization of pulsed saturation transfer MR fingerprinting (ST MRF) acquisition using the Cramér-Rao bound and sequential quadratic programming Article Swipe

PDF

Nikita Vladimirov , Moritz Zaiß , Or Perlman ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.48550/arxiv.2504.03298

Purpose: To develop a method for optimizing pulsed saturation transfer MR fingerprinting (ST MRF) acquisition. Methods: The Cramér-Rao bound (CRB) for variance assessment was employed on Bloch-McConnell-based simulated signals, followed by a numerical sequential quadratic programming optimization and basin-hopping avoidance of local minima. Validation was performed using L-arginine phantoms and healthy human volunteers (n=4) at 3T while restricting the scan time to be less than 40 s. Results: The proposed optimization approach resulted in a significantly improved agreement with reference gold standard values in vivo, compared to baseline non-optimized protocols (8$\%$ lower NRMSE, 7$\%$ higher SSIM, and 15$\%$ higher Pearson's r value, p<0.001). Conclusion: The combination of the CRB with sequential quadratic programming and a rapid Bloch-McConnell simulator offers a means for optimizing and accelerating pulsed CEST and semisolid magnetization transfer (MT) MRF acquisition.

Related Topics

Ant Colony Optimization Algorithms

Search Engine Optimization

Saturation Diving

Particle Swarm Optimization

Pulsed Electromagnetic Field Therapy

Oxygen Saturation (Medicine)

Combinatorial Optimization

Saturation (Brockhampton Album)

Concepts

No concepts available.

Metadata

Type: preprint
Language: en
Landing Page: http://arxiv.org/abs/2504.03298
PDF: https://arxiv.org/pdf/2504.03298
OA Status: green
OpenAlex ID: https://openalex.org/W4415196352

All OpenAlex metadata

Raw OpenAlex JSON

OpenAlex ID: https://openalex.org/W4415196352

Canonical identifier for this work in OpenAlex
DOI: https://doi.org/10.48550/arxiv.2504.03298

Digital Object Identifier
Title: Optimization of pulsed saturation transfer MR fingerprinting (ST MRF) acquisition using the Cramér-Rao bound and sequential quadratic programming

Work title
Type: preprint

OpenAlex work type
Language: en

Primary language
Publication year: 2025

Year of publication
Publication date: 2025-04-04

Full publication date if available
Authors: Nikita Vladimirov, Moritz Zaiß, Or Perlman

List of authors in order
Landing page: https://arxiv.org/abs/2504.03298

Publisher landing page
PDF URL: https://arxiv.org/pdf/2504.03298

Direct link to full text PDF
Open access: Yes

Whether a free full text is available
OA status: green

Open access status per OpenAlex
OA URL: https://arxiv.org/pdf/2504.03298

Direct OA link when available
Cited by: 0

Total citation count in OpenAlex

Full payload

id	https://openalex.org/W4415196352
doi	https://doi.org/10.48550/arxiv.2504.03298
ids.doi	https://doi.org/10.48550/arxiv.2504.03298
ids.openalex	https://openalex.org/W4415196352
fwci
type	preprint
title	Optimization of pulsed saturation transfer MR fingerprinting (ST MRF) acquisition using the Cramér-Rao bound and sequential quadratic programming
biblio.issue
biblio.volume
biblio.last_page
biblio.first_page
topics[0].id	https://openalex.org/T10378
topics[0].field.id	https://openalex.org/fields/27
topics[0].field.display_name	Medicine
topics[0].score	0.9865000247955322
topics[0].domain.id	https://openalex.org/domains/4
topics[0].domain.display_name	Health Sciences
topics[0].subfield.id	https://openalex.org/subfields/2741
topics[0].subfield.display_name	Radiology, Nuclear Medicine and Imaging
topics[0].display_name	Advanced MRI Techniques and Applications
is_xpac	False
apc_list
apc_paid
language	en
locations[0].id	pmh:oai:arXiv.org:2504.03298
locations[0].is_oa	True
locations[0].source.id	https://openalex.org/S4306400194
locations[0].source.issn
locations[0].source.type	repository
locations[0].source.is_oa	True
locations[0].source.issn_l
locations[0].source.is_core	False
locations[0].source.is_in_doaj	False
locations[0].source.display_name	arXiv (Cornell University)
locations[0].source.host_organization	https://openalex.org/I205783295
locations[0].source.host_organization_name	Cornell University
locations[0].source.host_organization_lineage	https://openalex.org/I205783295
locations[0].license
locations[0].pdf_url	https://arxiv.org/pdf/2504.03298
locations[0].version	submittedVersion
locations[0].raw_type	text
locations[0].license_id
locations[0].is_accepted	False
locations[0].is_published	False
locations[0].raw_source_name
locations[0].landing_page_url	http://arxiv.org/abs/2504.03298
locations[1].id	doi:10.48550/arxiv.2504.03298
locations[1].is_oa	True
locations[1].source.id	https://openalex.org/S4306400194
locations[1].source.issn
locations[1].source.type	repository
locations[1].source.is_oa	True
locations[1].source.issn_l
locations[1].source.is_core	False
locations[1].source.is_in_doaj	False
locations[1].source.display_name	arXiv (Cornell University)
locations[1].source.host_organization	https://openalex.org/I205783295
locations[1].source.host_organization_name	Cornell University
locations[1].source.host_organization_lineage	https://openalex.org/I205783295
locations[1].license	cc-by
locations[1].pdf_url
locations[1].version
locations[1].raw_type	article
locations[1].license_id	https://openalex.org/licenses/cc-by
locations[1].is_accepted	False
locations[1].is_published
locations[1].raw_source_name
locations[1].landing_page_url	https://doi.org/10.48550/arxiv.2504.03298
indexed_in	arxiv, datacite
authorships[0].author.id	https://openalex.org/A5078478374
authorships[0].author.orcid	https://orcid.org/0000-0002-1159-0689
authorships[0].author.display_name	Nikita Vladimirov
authorships[0].author_position	first
authorships[0].raw_author_name	Vladimirov, Nikita
authorships[0].is_corresponding	False
authorships[1].author.id	https://openalex.org/A5054149506
authorships[1].author.orcid	https://orcid.org/0000-0001-9780-3616
authorships[1].author.display_name	Moritz Zaiß
authorships[1].author_position	middle
authorships[1].raw_author_name	Zaiss, Moritz
authorships[1].is_corresponding	False
authorships[2].author.id	https://openalex.org/A5027178832
authorships[2].author.orcid	https://orcid.org/0000-0002-3566-569X
authorships[2].author.display_name	Or Perlman
authorships[2].author_position	last
authorships[2].raw_author_name	Perlman, Or
authorships[2].is_corresponding	False
has_content.pdf	False
has_content.grobid_xml	False
is_paratext	False
open_access.is_oa	True
open_access.oa_url	https://arxiv.org/pdf/2504.03298
open_access.oa_status	green
open_access.any_repository_has_fulltext	False
created_date	2025-10-15T00:00:00
display_name	Optimization of pulsed saturation transfer MR fingerprinting (ST MRF) acquisition using the Cramér-Rao bound and sequential quadratic programming
has_fulltext	False
is_retracted	False
updated_date	2025-11-06T06:51:31.235846
primary_topic.id	https://openalex.org/T10378
primary_topic.field.id	https://openalex.org/fields/27
primary_topic.field.display_name	Medicine
primary_topic.score	0.9865000247955322
primary_topic.domain.id	https://openalex.org/domains/4
primary_topic.domain.display_name	Health Sciences
primary_topic.subfield.id	https://openalex.org/subfields/2741
primary_topic.subfield.display_name	Radiology, Nuclear Medicine and Imaging
primary_topic.display_name	Advanced MRI Techniques and Applications
cited_by_count	0
locations_count	2
best_oa_location.id	pmh:oai:arXiv.org:2504.03298
best_oa_location.is_oa	True
best_oa_location.source.id	https://openalex.org/S4306400194
best_oa_location.source.issn
best_oa_location.source.type	repository
best_oa_location.source.is_oa	True
best_oa_location.source.issn_l
best_oa_location.source.is_core	False
best_oa_location.source.is_in_doaj	False
best_oa_location.source.display_name	arXiv (Cornell University)
best_oa_location.source.host_organization	https://openalex.org/I205783295
best_oa_location.source.host_organization_name	Cornell University
best_oa_location.source.host_organization_lineage	https://openalex.org/I205783295
best_oa_location.license
best_oa_location.pdf_url	https://arxiv.org/pdf/2504.03298
best_oa_location.version	submittedVersion
best_oa_location.raw_type	text
best_oa_location.license_id
best_oa_location.is_accepted	False
best_oa_location.is_published	False
best_oa_location.raw_source_name
best_oa_location.landing_page_url	http://arxiv.org/abs/2504.03298
primary_location.id	pmh:oai:arXiv.org:2504.03298
primary_location.is_oa	True
primary_location.source.id	https://openalex.org/S4306400194
primary_location.source.issn
primary_location.source.type	repository
primary_location.source.is_oa	True
primary_location.source.issn_l
primary_location.source.is_core	False
primary_location.source.is_in_doaj	False
primary_location.source.display_name	arXiv (Cornell University)
primary_location.source.host_organization	https://openalex.org/I205783295
primary_location.source.host_organization_name	Cornell University
primary_location.source.host_organization_lineage	https://openalex.org/I205783295
primary_location.license
primary_location.pdf_url	https://arxiv.org/pdf/2504.03298
primary_location.version	submittedVersion
primary_location.raw_type	text
primary_location.license_id
primary_location.is_accepted	False
primary_location.is_published	False
primary_location.raw_source_name
primary_location.landing_page_url	http://arxiv.org/abs/2504.03298
publication_date	2025-04-04
publication_year	2025
referenced_works_count	0
abstract_inverted_index.a	3, 31, 74, 114, 119
abstract_inverted_index.r	100
abstract_inverted_index.3T	55
abstract_inverted_index.40	65
abstract_inverted_index.MR	10
abstract_inverted_index.To	1
abstract_inverted_index.at	54
abstract_inverted_index.be	62
abstract_inverted_index.by	30
abstract_inverted_index.in	73, 83
abstract_inverted_index.of	40, 106
abstract_inverted_index.on	25
abstract_inverted_index.s.	66
abstract_inverted_index.to	61, 86
abstract_inverted_index.(ST	12
abstract_inverted_index.CRB	108
abstract_inverted_index.MRF	132
abstract_inverted_index.The	16, 68, 104
abstract_inverted_index.and	37, 49, 96, 113, 123, 127
abstract_inverted_index.for	5, 20, 121
abstract_inverted_index.the	58, 107
abstract_inverted_index.was	23, 44
abstract_inverted_index.(MT)	131
abstract_inverted_index.CEST	126
abstract_inverted_index.MRF)	13
abstract_inverted_index.gold	80
abstract_inverted_index.less	63
abstract_inverted_index.scan	59
abstract_inverted_index.than	64
abstract_inverted_index.time	60
abstract_inverted_index.with	78, 109
abstract_inverted_index.(CRB)	19
abstract_inverted_index.(n=4)	53
abstract_inverted_index.7$\%$	93
abstract_inverted_index.SSIM,	95
abstract_inverted_index.bound	18
abstract_inverted_index.human	51
abstract_inverted_index.local	41
abstract_inverted_index.lower	91
abstract_inverted_index.means	120
abstract_inverted_index.rapid	115
abstract_inverted_index.using	46
abstract_inverted_index.vivo,	84
abstract_inverted_index.while	56
abstract_inverted_index.(8$\%$	90
abstract_inverted_index.15$\%$	97
abstract_inverted_index.NRMSE,	92
abstract_inverted_index.higher	94, 98
abstract_inverted_index.method	4
abstract_inverted_index.offers	118
abstract_inverted_index.pulsed	7, 125
abstract_inverted_index.value,	101
abstract_inverted_index.values	82
abstract_inverted_index.develop	2
abstract_inverted_index.healthy	50
abstract_inverted_index.minima.	42
abstract_inverted_index.Methods:	15
abstract_inverted_index.Purpose:	0
abstract_inverted_index.Results:	67
abstract_inverted_index.approach	71
abstract_inverted_index.baseline	87
abstract_inverted_index.compared	85
abstract_inverted_index.employed	24
abstract_inverted_index.followed	29
abstract_inverted_index.improved	76
abstract_inverted_index.phantoms	48
abstract_inverted_index.proposed	69
abstract_inverted_index.resulted	72
abstract_inverted_index.signals,	28
abstract_inverted_index.standard	81
abstract_inverted_index.transfer	9, 130
abstract_inverted_index.variance	21
abstract_inverted_index.Pearson's	99
abstract_inverted_index.agreement	77
abstract_inverted_index.avoidance	39
abstract_inverted_index.numerical	32
abstract_inverted_index.performed	45
abstract_inverted_index.protocols	89
abstract_inverted_index.quadratic	34, 111
abstract_inverted_index.reference	79
abstract_inverted_index.semisolid	128
abstract_inverted_index.simulated	27
abstract_inverted_index.simulator	117
abstract_inverted_index.L-arginine	47
abstract_inverted_index.Validation	43
abstract_inverted_index.assessment	22
abstract_inverted_index.optimizing	6, 122
abstract_inverted_index.saturation	8
abstract_inverted_index.sequential	33, 110
abstract_inverted_index.volunteers	52
abstract_inverted_index.Conclusion:	103
abstract_inverted_index.Cramér-Rao	17
abstract_inverted_index.combination	105
abstract_inverted_index.programming	35, 112
abstract_inverted_index.restricting	57
abstract_inverted_index.accelerating	124
abstract_inverted_index.acquisition.	14, 133
abstract_inverted_index.optimization	36, 70
abstract_inverted_index.p<0.001).	102
abstract_inverted_index.basin-hopping	38
abstract_inverted_index.magnetization	129
abstract_inverted_index.non-optimized	88
abstract_inverted_index.significantly	75
abstract_inverted_index.fingerprinting	11
abstract_inverted_index.Bloch-McConnell	116
abstract_inverted_index.Bloch-McConnell-based	26
cited_by_percentile_year
countries_distinct_count	0
institutions_distinct_count	3
citation_normalized_percentile