Optimizing Gluten Extraction Using Eco-friendly Imidazolium-Based Ionic Liquids: Exploring the Impact of Cation Side Chains and Anions Article Swipe
Wenhao Chen
,
Chuan-Chih Hsu
,
Hui-Yin Huang
,
Jong‐Yuh Cherng
,
Yu‐Cheng Hsiao
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1021/acsomega.3c08683
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1021/acsomega.3c08683
Gluten is a well-known food allergen globally, and it can induce immune responses in celiac- and nonceliac gluten-sensitive patients. The gliadin proteins from gluten have a special amino acid sequence that make it hydrophobic. One way to deal with gluten allergies is to provide a gluten-free diet. The hydrophobic characteristic of gliadin makes gliadin detection more difficult. An analyst needs to use an organic solvent or multiple processes to denature gluten for extraction. Although organic solvents can rapidly extract gluten in a sample, organic solvent also denatures the antibody and induces false biotest results without buffer dilute, and the accuracy will reduce with buffer dilute. An ionic liquid (IL) is a highly modifiable green chemical organic salt. The imidazolium has a cationic structure and is modified with different lengths (C = 0, 1, 3, 5, 7, 9, and 12) of carbon side chains with organic and inorganic anions [methanesulfonate (MSO), Cl-, F-, NO3-, HSO4-, and H2PO4-] to make different kinds of ILs for testing the solubility of gliadin. Different IL/water ratios were used to test the solubility of gluten. We measured the solubility of gliadin in different imidazolium ILs, and the kinetic curve of gliadin dissolved in 1% [C5DMIM][MSO]aq was conducted. We also used circular dichroism spectroscopy and an enzyme-linked immunosorbent assay to measure the gliadin structure and the effect of binding with an antibody after 1% [C5DMIM][MSO]aq treatment. An 2,3-bis-(2-methoxy-4- nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT) assay was used to test the toxicity of [C5DMIM][MSO]aq in N2a cells. In our research, 1% [C5DMIM][MSO]aq produced a good solubility of gluten, and it could dissolve more than 3000 ppm of gluten in 5 min. [C5DMIM][MSO]aq did not break down the gluten structure and did not restrict antibody binding to gluten, and more importantly, [C5DMIM][MSO] did not exhibit cell toxicity. In this report, we showed that [C5DMIM][MSO] could be a good extraction solution applied for gluten detection.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1021/acsomega.3c08683
- https://pubs.acs.org/doi/pdf/10.1021/acsomega.3c08683
- OA Status
- gold
- Cited By
- 2
- References
- 33
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4393409796
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4393409796Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1021/acsomega.3c08683Digital Object Identifier
- Title
-
Optimizing Gluten Extraction Using Eco-friendly Imidazolium-Based Ionic Liquids: Exploring the Impact of Cation Side Chains and AnionsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-04-02Full publication date if available
- Authors
-
Wenhao Chen, Chuan-Chih Hsu, Hui-Yin Huang, Jong‐Yuh Cherng, Yu‐Cheng HsiaoList of authors in order
- Landing page
-
https://doi.org/10.1021/acsomega.3c08683Publisher landing page
- PDF URL
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https://pubs.acs.org/doi/pdf/10.1021/acsomega.3c08683Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://pubs.acs.org/doi/pdf/10.1021/acsomega.3c08683Direct OA link when available
- Concepts
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Ionic liquid, Extraction (chemistry), Environmentally friendly, Side chain, Gluten, Chemistry, Ion, Chemical engineering, Process engineering, Chromatography, Organic chemistry, Engineering, Food science, Catalysis, Ecology, Polymer, BiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
2Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 1Per-year citation counts (last 5 years)
- References (count)
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33Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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