Orai3 and Orai1 are essential for CRAC channel function and metabolic reprogramming in B cells Article Swipe
Scott M. Emrich
,
Ryan E. Yoast
,
Xuexin Zhang
,
Adam J. Fike
,
Yin‐Hu Wang
,
Kristen N Bricker
,
Anthony Tao
,
Ping Xin
,
Vonn Walter
,
Martin Johnson
,
Trayambak Pathak
,
Adam C. Straub
,
Stefan Feske
,
Ziaur S. M. Rahman
,
Mohamed Trebak
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1101/2022.05.06.490918
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1101/2022.05.06.490918
The essential role of store-operated Ca 2+ entry (SOCE) through Ca 2+ release-activated Ca 2+ (CRAC) channels in T cells is well established. In contrast, the contribution of individual Orai isoforms to SOCE and their downstream signaling functions in B cells are poorly understood. Here, we demonstrate changes in expression of Orai isoforms in response to B cell activation. We show that Orai3 and Orai1 are essential components of native CRAC channels in B cells and are critical for primary B cell proliferation and survival. The combined loss of Orai1 and Orai3 strongly impairs SOCE, nuclear factor for activated T cells (NFAT) activation, mitochondrial respiration, glycolysis, and the metabolic reprogramming of B cells in response to antigenic stimulation. Our results clarify the molecular composition and cellular functions of SOCE in B lymphocytes.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2022.05.06.490918
- https://www.biorxiv.org/content/biorxiv/early/2022/05/06/2022.05.06.490918.full.pdf
- OA Status
- green
- Cited By
- 1
- References
- 60
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4229014754
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4229014754Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2022.05.06.490918Digital Object Identifier
- Title
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Orai3 and Orai1 are essential for CRAC channel function and metabolic reprogramming in B cellsWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-05-06Full publication date if available
- Authors
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Scott M. Emrich, Ryan E. Yoast, Xuexin Zhang, Adam J. Fike, Yin‐Hu Wang, Kristen N Bricker, Anthony Tao, Ping Xin, Vonn Walter, Martin Johnson, Trayambak Pathak, Adam C. Straub, Stefan Feske, Ziaur S. M. Rahman, Mohamed TrebakList of authors in order
- Landing page
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https://doi.org/10.1101/2022.05.06.490918Publisher landing page
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https://www.biorxiv.org/content/biorxiv/early/2022/05/06/2022.05.06.490918.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
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-
greenOpen access status per OpenAlex
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https://www.biorxiv.org/content/biorxiv/early/2022/05/06/2022.05.06.490918.full.pdfDirect OA link when available
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ORAI1, NFAT, Cell biology, Reprogramming, Biology, STIM1, Chemistry, Cell, Biochemistry, Transcription factor, Endoplasmic reticulum, GeneTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2022: 1Per-year citation counts (last 5 years)
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60Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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