Orai3 and Orai1 mediate CRAC channel function and metabolic reprogramming in B cells Article Swipe
Scott M. Emrich
,
Ryan E. Yoast
,
Xuexin Zhang
,
Adam J. Fike
,
Yin‐Hu Wang
,
Kristen N Bricker
,
Anthony Tao
,
Ping Xin
,
Vonn Walter
,
Martin Johnson
,
Trayambak Pathak
,
Adam C. Straub
,
Stefan Feske
,
Ziaur S. M. Rahman
,
Mohamed Trebak
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.7554/elife.84708
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.7554/elife.84708
The essential role of store-operated Ca 2+ entry (SOCE) through Ca 2+ release-activated Ca 2+ (CRAC) channels in T cells is well established. In contrast, the contribution of individual Orai isoforms to SOCE and their downstream signaling functions in B cells are poorly understood. Here, we demonstrate changes in the expression of Orai isoforms in response to B cell activation. We show that both Orai3 and Orai1 mediate native CRAC channels in B cells. The combined loss of Orai1 and Orai3, but not Orai3 alone, impairs SOCE, proliferation and survival, nuclear factor of activated T cells (NFAT) activation, mitochondrial respiration, glycolysis, and the metabolic reprogramming of primary B cells in response to antigenic stimulation. Nevertheless, the combined deletion of Orai1 and Orai3 in B cells did not compromise humoral immunity to influenza A virus infection in mice, suggesting that other in vivo co-stimulatory signals can overcome the requirement of BCR-mediated CRAC channel function in B cells. Our results shed important new light on the physiological roles of Orai1 and Orai3 proteins in SOCE and the effector functions of B lymphocytes.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.7554/elife.84708
- OA Status
- gold
- Cited By
- 17
- References
- 75
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4321453125
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4321453125Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.7554/elife.84708Digital Object Identifier
- Title
-
Orai3 and Orai1 mediate CRAC channel function and metabolic reprogramming in B cellsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-02-21Full publication date if available
- Authors
-
Scott M. Emrich, Ryan E. Yoast, Xuexin Zhang, Adam J. Fike, Yin‐Hu Wang, Kristen N Bricker, Anthony Tao, Ping Xin, Vonn Walter, Martin Johnson, Trayambak Pathak, Adam C. Straub, Stefan Feske, Ziaur S. M. Rahman, Mohamed TrebakList of authors in order
- Landing page
-
https://doi.org/10.7554/elife.84708Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.7554/elife.84708Direct OA link when available
- Concepts
-
ORAI1, Reprogramming, Cell biology, Function (biology), Biology, Chemistry, STIM1, Cell, Genetics, Endoplasmic reticulumTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
17Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 5, 2024: 5, 2023: 7Per-year citation counts (last 5 years)
- References (count)
-
75Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4321453125 |
|---|---|
| doi | https://doi.org/10.7554/elife.84708 |
| ids.doi | https://doi.org/10.7554/elife.84708 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/36803766 |
| ids.openalex | https://openalex.org/W4321453125 |
| fwci | 4.75767221 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D000818 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Animals |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D051379 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Mice |
| mesh[2].qualifier_ui | Q000378 |
| mesh[2].descriptor_ui | D001402 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | metabolism |
| mesh[2].descriptor_name | B-Lymphocytes |
| mesh[3].qualifier_ui | Q000378 |
| mesh[3].descriptor_ui | D002118 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | metabolism |
| mesh[3].descriptor_name | Calcium |
| mesh[4].qualifier_ui | Q000378 |
| mesh[4].descriptor_ui | D015220 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | metabolism |
| mesh[4].descriptor_name | Calcium Channels |
| mesh[5].qualifier_ui | Q000502 |
| mesh[5].descriptor_ui | D020013 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | physiology |
| mesh[5].descriptor_name | Calcium Signaling |
| mesh[6].qualifier_ui | Q000235 |
| mesh[6].descriptor_ui | D000071740 |
| mesh[6].is_major_topic | True |
| mesh[6].qualifier_name | genetics |
| mesh[6].descriptor_name | ORAI1 Protein |
| mesh[7].qualifier_ui | Q000378 |
| mesh[7].descriptor_ui | D000071740 |
| mesh[7].is_major_topic | True |
| mesh[7].qualifier_name | metabolism |
| mesh[7].descriptor_name | ORAI1 Protein |
| mesh[8].qualifier_ui | Q000235 |
| mesh[8].descriptor_ui | D000071737 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | genetics |
| mesh[8].descriptor_name | Stromal Interaction Molecule 1 |
| mesh[9].qualifier_ui | Q000378 |
| mesh[9].descriptor_ui | D000071737 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | metabolism |
| mesh[9].descriptor_name | Stromal Interaction Molecule 1 |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D000818 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Animals |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D051379 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Mice |
| mesh[12].qualifier_ui | Q000378 |
| mesh[12].descriptor_ui | D001402 |
| mesh[12].is_major_topic | True |
| mesh[12].qualifier_name | metabolism |
| mesh[12].descriptor_name | B-Lymphocytes |
| mesh[13].qualifier_ui | Q000378 |
| mesh[13].descriptor_ui | D002118 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | metabolism |
| mesh[13].descriptor_name | Calcium |
| mesh[14].qualifier_ui | Q000378 |
| mesh[14].descriptor_ui | D015220 |
| mesh[14].is_major_topic | True |
| mesh[14].qualifier_name | metabolism |
| mesh[14].descriptor_name | Calcium Channels |
| mesh[15].qualifier_ui | Q000502 |
| mesh[15].descriptor_ui | D020013 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | physiology |
| mesh[15].descriptor_name | Calcium Signaling |
| mesh[16].qualifier_ui | Q000235 |
| mesh[16].descriptor_ui | D000071740 |
| mesh[16].is_major_topic | True |
| mesh[16].qualifier_name | genetics |
| mesh[16].descriptor_name | ORAI1 Protein |
| mesh[17].qualifier_ui | Q000378 |
| mesh[17].descriptor_ui | D000071740 |
| mesh[17].is_major_topic | True |
| mesh[17].qualifier_name | metabolism |
| mesh[17].descriptor_name | ORAI1 Protein |
| mesh[18].qualifier_ui | Q000235 |
| mesh[18].descriptor_ui | D000071737 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | genetics |
| mesh[18].descriptor_name | Stromal Interaction Molecule 1 |
| mesh[19].qualifier_ui | Q000378 |
| mesh[19].descriptor_ui | D000071737 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | metabolism |
| mesh[19].descriptor_name | Stromal Interaction Molecule 1 |
| type | article |
| title | Orai3 and Orai1 mediate CRAC channel function and metabolic reprogramming in B cells |
| awards[0].id | https://openalex.org/G7542197905 |
| awards[0].funder_id | https://openalex.org/F4320337355 |
| awards[0].display_name | |
| awards[0].funder_award_id | F30-AI164803-01 |
| awards[0].funder_display_name | National Institute of Allergy and Infectious Diseases |
| awards[1].id | https://openalex.org/G4267617636 |
| awards[1].funder_id | https://openalex.org/F4320337338 |
| awards[1].display_name | |
| awards[1].funder_award_id | R35-HL150778 |
| awards[1].funder_display_name | National Heart, Lung, and Blood Institute |
| biblio.issue | |
| biblio.volume | 12 |
| biblio.last_page | |
| biblio.first_page | |
| topics[0].id | https://openalex.org/T11204 |
| topics[0].field.id | https://openalex.org/fields/28 |
| topics[0].field.display_name | Neuroscience |
| topics[0].score | 0.9990000128746033 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2809 |
| topics[0].subfield.display_name | Sensory Systems |
| topics[0].display_name | Ion Channels and Receptors |
| topics[1].id | https://openalex.org/T10423 |
| topics[1].field.id | https://openalex.org/fields/28 |
| topics[1].field.display_name | Neuroscience |
| topics[1].score | 0.9848999977111816 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2804 |
| topics[1].subfield.display_name | Cellular and Molecular Neuroscience |
| topics[1].display_name | Neurobiology and Insect Physiology Research |
| topics[2].id | https://openalex.org/T10035 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9513999819755554 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2704 |
| topics[2].subfield.display_name | Biochemistry |
| topics[2].display_name | Phytochemicals and Antioxidant Activities |
| funders[0].id | https://openalex.org/F4320337338 |
| funders[0].ror | https://ror.org/012pb6c26 |
| funders[0].display_name | National Heart, Lung, and Blood Institute |
| funders[1].id | https://openalex.org/F4320337355 |
| funders[1].ror | https://ror.org/043z4tv69 |
| funders[1].display_name | National Institute of Allergy and Infectious Diseases |
| is_xpac | False |
| apc_list.value | 3000 |
| apc_list.currency | USD |
| apc_list.value_usd | 2500 |
| apc_paid.value | 3000 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 2500 |
| concepts[0].id | https://openalex.org/C2776610495 |
| concepts[0].level | 4 |
| concepts[0].score | 0.8503138422966003 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q18047835 |
| concepts[0].display_name | ORAI1 |
| concepts[1].id | https://openalex.org/C77255625 |
| concepts[1].level | 3 |
| concepts[1].score | 0.7916411757469177 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q402093 |
| concepts[1].display_name | Reprogramming |
| concepts[2].id | https://openalex.org/C95444343 |
| concepts[2].level | 1 |
| concepts[2].score | 0.7071701288223267 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[2].display_name | Cell biology |
| concepts[3].id | https://openalex.org/C14036430 |
| concepts[3].level | 2 |
| concepts[3].score | 0.5411149859428406 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q3736076 |
| concepts[3].display_name | Function (biology) |
| concepts[4].id | https://openalex.org/C86803240 |
| concepts[4].level | 0 |
| concepts[4].score | 0.4547419548034668 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[4].display_name | Biology |
| concepts[5].id | https://openalex.org/C185592680 |
| concepts[5].level | 0 |
| concepts[5].score | 0.35566431283950806 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[5].display_name | Chemistry |
| concepts[6].id | https://openalex.org/C162740809 |
| concepts[6].level | 3 |
| concepts[6].score | 0.190275639295578 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q15334560 |
| concepts[6].display_name | STIM1 |
| concepts[7].id | https://openalex.org/C1491633281 |
| concepts[7].level | 2 |
| concepts[7].score | 0.18658652901649475 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q7868 |
| concepts[7].display_name | Cell |
| concepts[8].id | https://openalex.org/C54355233 |
| concepts[8].level | 1 |
| concepts[8].score | 0.13138064742088318 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[8].display_name | Genetics |
| concepts[9].id | https://openalex.org/C158617107 |
| concepts[9].level | 2 |
| concepts[9].score | 0.0 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q79927 |
| concepts[9].display_name | Endoplasmic reticulum |
| keywords[0].id | https://openalex.org/keywords/orai1 |
| keywords[0].score | 0.8503138422966003 |
| keywords[0].display_name | ORAI1 |
| keywords[1].id | https://openalex.org/keywords/reprogramming |
| keywords[1].score | 0.7916411757469177 |
| keywords[1].display_name | Reprogramming |
| keywords[2].id | https://openalex.org/keywords/cell-biology |
| keywords[2].score | 0.7071701288223267 |
| keywords[2].display_name | Cell biology |
| keywords[3].id | https://openalex.org/keywords/function |
| keywords[3].score | 0.5411149859428406 |
| keywords[3].display_name | Function (biology) |
| keywords[4].id | https://openalex.org/keywords/biology |
| keywords[4].score | 0.4547419548034668 |
| keywords[4].display_name | Biology |
| keywords[5].id | https://openalex.org/keywords/chemistry |
| keywords[5].score | 0.35566431283950806 |
| keywords[5].display_name | Chemistry |
| keywords[6].id | https://openalex.org/keywords/stim1 |
| keywords[6].score | 0.190275639295578 |
| keywords[6].display_name | STIM1 |
| keywords[7].id | https://openalex.org/keywords/cell |
| keywords[7].score | 0.18658652901649475 |
| keywords[7].display_name | Cell |
| keywords[8].id | https://openalex.org/keywords/genetics |
| keywords[8].score | 0.13138064742088318 |
| keywords[8].display_name | Genetics |
| language | en |
| locations[0].id | doi:10.7554/elife.84708 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S1336409049 |
| locations[0].source.issn | 2050-084X |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2050-084X |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | eLife |
| locations[0].source.host_organization | https://openalex.org/P4310311710 |
| locations[0].source.host_organization_name | eLife Sciences Publications Ltd |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310311710 |
| locations[0].source.host_organization_lineage_names | eLife Sciences Publications Ltd |
| locations[0].license | cc-by |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | eLife |
| locations[0].landing_page_url | https://doi.org/10.7554/elife.84708 |
| locations[1].id | pmid:36803766 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | eLife |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/36803766 |
| locations[2].id | pmh:oai:doaj.org/article:5b4624a722da497c9f2661a9b380baec |
| locations[2].is_oa | False |
| locations[2].source.id | https://openalex.org/S4306401280 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[2].source.host_organization | |
| locations[2].source.host_organization_name | |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | article |
| locations[2].license_id | |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | eLife, Vol 12 (2023) |
| locations[2].landing_page_url | https://doaj.org/article/5b4624a722da497c9f2661a9b380baec |
| locations[3].id | pmh:oai:pubmedcentral.nih.gov:9998091 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S2764455111 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | PubMed Central |
| locations[3].source.host_organization | https://openalex.org/I1299303238 |
| locations[3].source.host_organization_name | National Institutes of Health |
| locations[3].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[3].license | cc-by |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | https://openalex.org/licenses/cc-by |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | eLife |
| locations[3].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/9998091 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5011499966 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-4804-7436 |
| authorships[0].author.display_name | Scott M. Emrich |
| authorships[0].countries | US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I130769515 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine |
| authorships[0].institutions[0].id | https://openalex.org/I130769515 |
| authorships[0].institutions[0].ror | https://ror.org/04p491231 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I130769515 |
| authorships[0].institutions[0].country_code | US |
| authorships[0].institutions[0].display_name | Pennsylvania State University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Scott M Emrich |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine |
| authorships[1].author.id | https://openalex.org/A5038670797 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-7059-6829 |
| authorships[1].author.display_name | Ryan E. Yoast |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I130769515 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine |
| authorships[1].institutions[0].id | https://openalex.org/I130769515 |
| authorships[1].institutions[0].ror | https://ror.org/04p491231 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I130769515 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | Pennsylvania State University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Ryan E Yoast |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine |
| authorships[2].author.id | https://openalex.org/A5063808923 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Xuexin Zhang |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I130769515 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine |
| authorships[2].institutions[0].id | https://openalex.org/I130769515 |
| authorships[2].institutions[0].ror | https://ror.org/04p491231 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I130769515 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | Pennsylvania State University |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Xuexin Zhang |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine |
| authorships[3].author.id | https://openalex.org/A5024095896 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-7105-6162 |
| authorships[3].author.display_name | Adam J. Fike |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I130769515 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Microbiology and Immunology, Pennsylvania State University College of Medicine |
| authorships[3].institutions[0].id | https://openalex.org/I130769515 |
| authorships[3].institutions[0].ror | https://ror.org/04p491231 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I130769515 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | Pennsylvania State University |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Adam J Fike |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Microbiology and Immunology, Pennsylvania State University College of Medicine |
| authorships[4].author.id | https://openalex.org/A5077890752 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-3637-8852 |
| authorships[4].author.display_name | Yin‐Hu Wang |
| authorships[4].countries | US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I4210153792, https://openalex.org/I57206974 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Pathology, New York University School of Medicine |
| authorships[4].institutions[0].id | https://openalex.org/I57206974 |
| authorships[4].institutions[0].ror | https://ror.org/0190ak572 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I57206974 |
| authorships[4].institutions[0].country_code | US |
| authorships[4].institutions[0].display_name | New York University |
| authorships[4].institutions[1].id | https://openalex.org/I4210153792 |
| authorships[4].institutions[1].ror | https://ror.org/05ap66461 |
| authorships[4].institutions[1].type | education |
| authorships[4].institutions[1].lineage | https://openalex.org/I4210153792 |
| authorships[4].institutions[1].country_code | US |
| authorships[4].institutions[1].display_name | University School |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Yin-Hu Wang |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Pathology, New York University School of Medicine |
| authorships[5].author.id | https://openalex.org/A5007290314 |
| authorships[5].author.orcid | https://orcid.org/0000-0001-8963-9780 |
| authorships[5].author.display_name | Kristen N Bricker |
| authorships[5].countries | US |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I130769515 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Microbiology and Immunology, Pennsylvania State University College of Medicine |
| authorships[5].institutions[0].id | https://openalex.org/I130769515 |
| authorships[5].institutions[0].ror | https://ror.org/04p491231 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I130769515 |
| authorships[5].institutions[0].country_code | US |
| authorships[5].institutions[0].display_name | Pennsylvania State University |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Kristen N Bricker |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Microbiology and Immunology, Pennsylvania State University College of Medicine |
| authorships[6].author.id | https://openalex.org/A5056967422 |
| authorships[6].author.orcid | https://orcid.org/0000-0003-0978-2769 |
| authorships[6].author.display_name | Anthony Tao |
| authorships[6].countries | US |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I4210153792, https://openalex.org/I57206974 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Pathology, New York University School of Medicine |
| authorships[6].institutions[0].id | https://openalex.org/I57206974 |
| authorships[6].institutions[0].ror | https://ror.org/0190ak572 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I57206974 |
| authorships[6].institutions[0].country_code | US |
| authorships[6].institutions[0].display_name | New York University |
| authorships[6].institutions[1].id | https://openalex.org/I4210153792 |
| authorships[6].institutions[1].ror | https://ror.org/05ap66461 |
| authorships[6].institutions[1].type | education |
| authorships[6].institutions[1].lineage | https://openalex.org/I4210153792 |
| authorships[6].institutions[1].country_code | US |
| authorships[6].institutions[1].display_name | University School |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Anthony Y Tao |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Pathology, New York University School of Medicine |
| authorships[7].author.id | https://openalex.org/A5109953026 |
| authorships[7].author.orcid | |
| authorships[7].author.display_name | Ping Xin |
| authorships[7].countries | US |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I170201317 |
| authorships[7].affiliations[0].raw_affiliation_string | Vascular Medicine Institute, University of Pittsburgh School of Medicine |
| authorships[7].affiliations[1].institution_ids | https://openalex.org/I170201317 |
| authorships[7].affiliations[1].raw_affiliation_string | Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine |
| authorships[7].institutions[0].id | https://openalex.org/I170201317 |
| authorships[7].institutions[0].ror | https://ror.org/01an3r305 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I170201317 |
| authorships[7].institutions[0].country_code | US |
| authorships[7].institutions[0].display_name | University of Pittsburgh |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Ping Xin |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Vascular Medicine Institute, University of Pittsburgh School of Medicine |
| authorships[8].author.id | https://openalex.org/A5086084361 |
| authorships[8].author.orcid | https://orcid.org/0000-0001-6114-6714 |
| authorships[8].author.display_name | Vonn Walter |
| authorships[8].countries | US |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I130769515 |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Public Health Sciences, Pennsylvania State University College of Medicine |
| authorships[8].institutions[0].id | https://openalex.org/I130769515 |
| authorships[8].institutions[0].ror | https://ror.org/04p491231 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I130769515 |
| authorships[8].institutions[0].country_code | US |
| authorships[8].institutions[0].display_name | Pennsylvania State University |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Vonn Walter |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Department of Public Health Sciences, Pennsylvania State University College of Medicine |
| authorships[9].author.id | https://openalex.org/A5087197408 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-4706-8294 |
| authorships[9].author.display_name | Martin Johnson |
| authorships[9].countries | US |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I130769515 |
| authorships[9].affiliations[0].raw_affiliation_string | Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine |
| authorships[9].institutions[0].id | https://openalex.org/I130769515 |
| authorships[9].institutions[0].ror | https://ror.org/04p491231 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I130769515 |
| authorships[9].institutions[0].country_code | US |
| authorships[9].institutions[0].display_name | Pennsylvania State University |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Martin T Johnson |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine |
| authorships[10].author.id | https://openalex.org/A5074073706 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-0719-2995 |
| authorships[10].author.display_name | Trayambak Pathak |
| authorships[10].countries | US |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I170201317 |
| authorships[10].affiliations[0].raw_affiliation_string | Vascular Medicine Institute, University of Pittsburgh School of Medicine |
| authorships[10].affiliations[1].institution_ids | https://openalex.org/I170201317 |
| authorships[10].affiliations[1].raw_affiliation_string | Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine |
| authorships[10].institutions[0].id | https://openalex.org/I170201317 |
| authorships[10].institutions[0].ror | https://ror.org/01an3r305 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I170201317 |
| authorships[10].institutions[0].country_code | US |
| authorships[10].institutions[0].display_name | University of Pittsburgh |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Trayambak Pathak |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Vascular Medicine Institute, University of Pittsburgh School of Medicine |
| authorships[11].author.id | https://openalex.org/A5079581156 |
| authorships[11].author.orcid | https://orcid.org/0000-0003-0542-9466 |
| authorships[11].author.display_name | Adam C. Straub |
| authorships[11].countries | US |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I170201317 |
| authorships[11].affiliations[0].raw_affiliation_string | Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine |
| authorships[11].affiliations[1].institution_ids | https://openalex.org/I170201317 |
| authorships[11].affiliations[1].raw_affiliation_string | Vascular Medicine Institute, University of Pittsburgh School of Medicine |
| authorships[11].institutions[0].id | https://openalex.org/I170201317 |
| authorships[11].institutions[0].ror | https://ror.org/01an3r305 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I170201317 |
| authorships[11].institutions[0].country_code | US |
| authorships[11].institutions[0].display_name | University of Pittsburgh |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Adam C Straub |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Vascular Medicine Institute, University of Pittsburgh School of Medicine |
| authorships[12].author.id | https://openalex.org/A5091404565 |
| authorships[12].author.orcid | https://orcid.org/0000-0001-5431-8178 |
| authorships[12].author.display_name | Stefan Feske |
| authorships[12].countries | US |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I4210153792, https://openalex.org/I57206974 |
| authorships[12].affiliations[0].raw_affiliation_string | Department of Pathology, New York University School of Medicine |
| authorships[12].institutions[0].id | https://openalex.org/I57206974 |
| authorships[12].institutions[0].ror | https://ror.org/0190ak572 |
| authorships[12].institutions[0].type | education |
| authorships[12].institutions[0].lineage | https://openalex.org/I57206974 |
| authorships[12].institutions[0].country_code | US |
| authorships[12].institutions[0].display_name | New York University |
| authorships[12].institutions[1].id | https://openalex.org/I4210153792 |
| authorships[12].institutions[1].ror | https://ror.org/05ap66461 |
| authorships[12].institutions[1].type | education |
| authorships[12].institutions[1].lineage | https://openalex.org/I4210153792 |
| authorships[12].institutions[1].country_code | US |
| authorships[12].institutions[1].display_name | University School |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Stefan Feske |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Department of Pathology, New York University School of Medicine |
| authorships[13].author.id | https://openalex.org/A5004491636 |
| authorships[13].author.orcid | https://orcid.org/0000-0001-8431-9681 |
| authorships[13].author.display_name | Ziaur S. M. Rahman |
| authorships[13].countries | US |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I130769515 |
| authorships[13].affiliations[0].raw_affiliation_string | Department of Microbiology and Immunology, Pennsylvania State University College of Medicine |
| authorships[13].institutions[0].id | https://openalex.org/I130769515 |
| authorships[13].institutions[0].ror | https://ror.org/04p491231 |
| authorships[13].institutions[0].type | education |
| authorships[13].institutions[0].lineage | https://openalex.org/I130769515 |
| authorships[13].institutions[0].country_code | US |
| authorships[13].institutions[0].display_name | Pennsylvania State University |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Ziaur SM Rahman |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Department of Microbiology and Immunology, Pennsylvania State University College of Medicine |
| authorships[14].author.id | https://openalex.org/A5061372270 |
| authorships[14].author.orcid | https://orcid.org/0000-0001-6759-864X |
| authorships[14].author.display_name | Mohamed Trebak |
| authorships[14].countries | US |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I170201317 |
| authorships[14].affiliations[0].raw_affiliation_string | Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine |
| authorships[14].affiliations[1].institution_ids | https://openalex.org/I170201317 |
| authorships[14].affiliations[1].raw_affiliation_string | Vascular Medicine Institute, University of Pittsburgh School of Medicine |
| authorships[14].affiliations[2].institution_ids | https://openalex.org/I130769515 |
| authorships[14].affiliations[2].raw_affiliation_string | Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine |
| authorships[14].institutions[0].id | https://openalex.org/I130769515 |
| authorships[14].institutions[0].ror | https://ror.org/04p491231 |
| authorships[14].institutions[0].type | education |
| authorships[14].institutions[0].lineage | https://openalex.org/I130769515 |
| authorships[14].institutions[0].country_code | US |
| authorships[14].institutions[0].display_name | Pennsylvania State University |
| authorships[14].institutions[1].id | https://openalex.org/I170201317 |
| authorships[14].institutions[1].ror | https://ror.org/01an3r305 |
| authorships[14].institutions[1].type | education |
| authorships[14].institutions[1].lineage | https://openalex.org/I170201317 |
| authorships[14].institutions[1].country_code | US |
| authorships[14].institutions[1].display_name | University of Pittsburgh |
| authorships[14].author_position | last |
| authorships[14].raw_author_name | Mohamed Trebak |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Vascular Medicine Institute, University of Pittsburgh School of Medicine |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.7554/elife.84708 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Orai3 and Orai1 mediate CRAC channel function and metabolic reprogramming in B cells |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-25T14:43:58.451035 |
| primary_topic.id | https://openalex.org/T11204 |
| primary_topic.field.id | https://openalex.org/fields/28 |
| primary_topic.field.display_name | Neuroscience |
| primary_topic.score | 0.9990000128746033 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2809 |
| primary_topic.subfield.display_name | Sensory Systems |
| primary_topic.display_name | Ion Channels and Receptors |
| related_works | https://openalex.org/W4391375266, https://openalex.org/W2082860237, https://openalex.org/W2119695867, https://openalex.org/W4309712946, https://openalex.org/W2130076355, https://openalex.org/W1990804418, https://openalex.org/W1993764875, https://openalex.org/W2046158694, https://openalex.org/W2144543766, https://openalex.org/W2565491615 |
| cited_by_count | 17 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 5 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 5 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 7 |
| locations_count | 4 |
| best_oa_location.id | doi:10.7554/elife.84708 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S1336409049 |
| best_oa_location.source.issn | 2050-084X |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2050-084X |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | eLife |
| best_oa_location.source.host_organization | https://openalex.org/P4310311710 |
| best_oa_location.source.host_organization_name | eLife Sciences Publications Ltd |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310311710 |
| best_oa_location.source.host_organization_lineage_names | eLife Sciences Publications Ltd |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | eLife |
| best_oa_location.landing_page_url | https://doi.org/10.7554/elife.84708 |
| primary_location.id | doi:10.7554/elife.84708 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S1336409049 |
| primary_location.source.issn | 2050-084X |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2050-084X |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | eLife |
| primary_location.source.host_organization | https://openalex.org/P4310311710 |
| primary_location.source.host_organization_name | eLife Sciences Publications Ltd |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310311710 |
| primary_location.source.host_organization_lineage_names | eLife Sciences Publications Ltd |
| primary_location.license | cc-by |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | eLife |
| primary_location.landing_page_url | https://doi.org/10.7554/elife.84708 |
| publication_date | 2023-02-21 |
| publication_year | 2023 |
| referenced_works | https://openalex.org/W2594635572, https://openalex.org/W2820849818, https://openalex.org/W2896276853, https://openalex.org/W1655771988, https://openalex.org/W2836363664, https://openalex.org/W3015418599, https://openalex.org/W2904107894, https://openalex.org/W2146664668, https://openalex.org/W2614424847, https://openalex.org/W2016348702, https://openalex.org/W2088729275, https://openalex.org/W4214925106, https://openalex.org/W2145825942, https://openalex.org/W2045949302, https://openalex.org/W2940619822, https://openalex.org/W3134190116, https://openalex.org/W4306933299, https://openalex.org/W3206934744, https://openalex.org/W2109453374, https://openalex.org/W2163789582, https://openalex.org/W3153859255, https://openalex.org/W2170287675, https://openalex.org/W2112645751, https://openalex.org/W1480476159, https://openalex.org/W3126810552, https://openalex.org/W1987318925, https://openalex.org/W2071688420, https://openalex.org/W2229423562, https://openalex.org/W2022012352, https://openalex.org/W2061743609, https://openalex.org/W1935830997, https://openalex.org/W2771037458, https://openalex.org/W2903101723, https://openalex.org/W2787240390, https://openalex.org/W2041181951, https://openalex.org/W1993781709, https://openalex.org/W2158719941, https://openalex.org/W2130116522, https://openalex.org/W2123106337, https://openalex.org/W2343452853, https://openalex.org/W2037289981, https://openalex.org/W1934528477, https://openalex.org/W2168342464, https://openalex.org/W2114104545, https://openalex.org/W2099540110, https://openalex.org/W2121711825, https://openalex.org/W1554199623, https://openalex.org/W2003829187, https://openalex.org/W2130410032, https://openalex.org/W2626337911, https://openalex.org/W2121586321, https://openalex.org/W2410950716, https://openalex.org/W2625835005, https://openalex.org/W2908770791, https://openalex.org/W2770227510, https://openalex.org/W2409804531, https://openalex.org/W2763526200, https://openalex.org/W2605821164, https://openalex.org/W2791358733, https://openalex.org/W3045267509, https://openalex.org/W2031966403, https://openalex.org/W4286493986, https://openalex.org/W2849483034, https://openalex.org/W3127935100, https://openalex.org/W3044421432, https://openalex.org/W3024569254, https://openalex.org/W3198444904, https://openalex.org/W2089040449, https://openalex.org/W2160697408, https://openalex.org/W2158243353, https://openalex.org/W1974161953, https://openalex.org/W2904984445, https://openalex.org/W2942151678, https://openalex.org/W3082760815, https://openalex.org/W2036145275 |
| referenced_works_count | 75 |
| abstract_inverted_index.A | 132 |
| abstract_inverted_index.B | 39, 57, 72, 107, 123, 154, 178 |
| abstract_inverted_index.T | 18, 94 |
| abstract_inverted_index.2+ | 6, 11, 14 |
| abstract_inverted_index.Ca | 5, 10, 13 |
| abstract_inverted_index.In | 23 |
| abstract_inverted_index.We | 60 |
| abstract_inverted_index.in | 17, 38, 48, 54, 71, 109, 122, 135, 140, 153, 171 |
| abstract_inverted_index.is | 20 |
| abstract_inverted_index.of | 3, 27, 51, 77, 92, 105, 118, 148, 166, 177 |
| abstract_inverted_index.on | 162 |
| abstract_inverted_index.to | 31, 56, 111, 130 |
| abstract_inverted_index.we | 45 |
| abstract_inverted_index.Our | 156 |
| abstract_inverted_index.The | 0, 74 |
| abstract_inverted_index.and | 33, 65, 79, 88, 101, 120, 168, 173 |
| abstract_inverted_index.are | 41 |
| abstract_inverted_index.but | 81 |
| abstract_inverted_index.can | 144 |
| abstract_inverted_index.did | 125 |
| abstract_inverted_index.new | 160 |
| abstract_inverted_index.not | 82, 126 |
| abstract_inverted_index.the | 25, 49, 102, 115, 146, 163, 174 |
| abstract_inverted_index.CRAC | 69, 150 |
| abstract_inverted_index.Orai | 29, 52 |
| abstract_inverted_index.SOCE | 32, 172 |
| abstract_inverted_index.both | 63 |
| abstract_inverted_index.cell | 58 |
| abstract_inverted_index.loss | 76 |
| abstract_inverted_index.role | 2 |
| abstract_inverted_index.shed | 158 |
| abstract_inverted_index.show | 61 |
| abstract_inverted_index.that | 62, 138 |
| abstract_inverted_index.vivo | 141 |
| abstract_inverted_index.well | 21 |
| abstract_inverted_index.Here, | 44 |
| abstract_inverted_index.Orai1 | 66, 78, 119, 167 |
| abstract_inverted_index.Orai3 | 64, 83, 121, 169 |
| abstract_inverted_index.SOCE, | 86 |
| abstract_inverted_index.cells | 19, 40, 95, 108, 124 |
| abstract_inverted_index.entry | 7 |
| abstract_inverted_index.light | 161 |
| abstract_inverted_index.mice, | 136 |
| abstract_inverted_index.other | 139 |
| abstract_inverted_index.roles | 165 |
| abstract_inverted_index.their | 34 |
| abstract_inverted_index.virus | 133 |
| abstract_inverted_index.(CRAC) | 15 |
| abstract_inverted_index.(NFAT) | 96 |
| abstract_inverted_index.(SOCE) | 8 |
| abstract_inverted_index.Orai3, | 80 |
| abstract_inverted_index.alone, | 84 |
| abstract_inverted_index.cells. | 73, 155 |
| abstract_inverted_index.factor | 91 |
| abstract_inverted_index.native | 68 |
| abstract_inverted_index.poorly | 42 |
| abstract_inverted_index.changes | 47 |
| abstract_inverted_index.channel | 151 |
| abstract_inverted_index.humoral | 128 |
| abstract_inverted_index.impairs | 85 |
| abstract_inverted_index.mediate | 67 |
| abstract_inverted_index.nuclear | 90 |
| abstract_inverted_index.primary | 106 |
| abstract_inverted_index.results | 157 |
| abstract_inverted_index.signals | 143 |
| abstract_inverted_index.through | 9 |
| abstract_inverted_index.channels | 16, 70 |
| abstract_inverted_index.combined | 75, 116 |
| abstract_inverted_index.deletion | 117 |
| abstract_inverted_index.effector | 175 |
| abstract_inverted_index.function | 152 |
| abstract_inverted_index.immunity | 129 |
| abstract_inverted_index.isoforms | 30, 53 |
| abstract_inverted_index.overcome | 145 |
| abstract_inverted_index.proteins | 170 |
| abstract_inverted_index.response | 55, 110 |
| abstract_inverted_index.activated | 93 |
| abstract_inverted_index.antigenic | 112 |
| abstract_inverted_index.contrast, | 24 |
| abstract_inverted_index.essential | 1 |
| abstract_inverted_index.functions | 37, 176 |
| abstract_inverted_index.important | 159 |
| abstract_inverted_index.infection | 134 |
| abstract_inverted_index.influenza | 131 |
| abstract_inverted_index.metabolic | 103 |
| abstract_inverted_index.signaling | 36 |
| abstract_inverted_index.survival, | 89 |
| abstract_inverted_index.compromise | 127 |
| abstract_inverted_index.downstream | 35 |
| abstract_inverted_index.expression | 50 |
| abstract_inverted_index.individual | 28 |
| abstract_inverted_index.suggesting | 137 |
| abstract_inverted_index.activation, | 97 |
| abstract_inverted_index.activation. | 59 |
| abstract_inverted_index.demonstrate | 46 |
| abstract_inverted_index.glycolysis, | 100 |
| abstract_inverted_index.requirement | 147 |
| abstract_inverted_index.understood. | 43 |
| abstract_inverted_index.BCR-mediated | 149 |
| abstract_inverted_index.contribution | 26 |
| abstract_inverted_index.established. | 22 |
| abstract_inverted_index.lymphocytes. | 179 |
| abstract_inverted_index.respiration, | 99 |
| abstract_inverted_index.stimulation. | 113 |
| abstract_inverted_index.Nevertheless, | 114 |
| abstract_inverted_index.mitochondrial | 98 |
| abstract_inverted_index.physiological | 164 |
| abstract_inverted_index.proliferation | 87 |
| abstract_inverted_index.reprogramming | 104 |
| abstract_inverted_index.co-stimulatory | 142 |
| abstract_inverted_index.store-operated | 4 |
| abstract_inverted_index.release-activated | 12 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 98 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 15 |
| citation_normalized_percentile.value | 0.94512569 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |