Oral Methods of Microbiota Manipulation for Depression Symptoms: A Systematic Review: Méthodes orales de manipulation du microbiote pour traiter les symptômes de dépression : Une revue systématique Article Swipe
Anna Oprea
,
J Steinman
,
Grace Huang
,
Omolara Soyinka
,
Megan Brookbank
,
James Abesteh
,
Maya Hartman
,
Joanna C. Dionne
,
Roumen Milev
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1177/07067437251394369
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1177/07067437251394369
Objective The effectiveness of current treatment options for depressive symptoms has been widely investigated with acknowledgment that some patients were either not adequately responding to treatment, finding the existing treatment intolerable, or otherwise prefer alternative options. There is increasing interest in microbiota modulation as an alternate form of depression treatment, with a growing number of trials and reviews on the subject published in the last five years. This systematic review aimed to analyze all completed randomized control trials (RCTs) that assessed depression symptoms in adults not using antidepressants, before and after oral methods of microbiota manipulation. Method All completed parallel-arm RCTs that assessed depression symptoms in adult participants before and after oral methods of microbiota manipulation were retrieved from four databases, MEDLINE, Embase, PsycINFO, and Cochrane Central Register of Controlled Trials. Data on study and intervention characteristics as well as RCT conclusions were collected independently and in duplicate, and each study's findings were summarized individually. Risk of bias was completed. Results We included 66 RCTs in our review, 34 of which concluded significant differences between the intervention and control group in depressive symptom using different interventions and measures. Of the 66 trials, 54 used probiotic interventions, seven used prebiotic, eight used synbiotic and two used oral fecal microbiota transplantation. Wide variation was observed in studies’ design, intervention composition and consumption methods across all 66 RCTs. No statistical synthesis or meta-analyses were possible due to the wide variety of interventions, measures and outcomes. Conclusions The heterogeneity of the existing RCTs did not allow for concrete conclusions on whether oral microbiota manipulation interventions are viable alternative treatment options for adults experiencing depression symptoms. We encourage the development of standardized guidelines for the design and reporting of microbiota studies in depression for the possibility of future intervention efficacy testing.
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Oral Methods of Microbiota Manipulation for Depression Symptoms: A Systematic Review: Méthodes orales de manipulation du microbiote pour traiter les symptômes de dépression : Une revue systématiqueWork title
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articleOpenAlex work type
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enPrimary language
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2025Year of publication
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2025-11-27Full publication date if available
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Anna Oprea, J Steinman, Grace Huang, Omolara Soyinka, Megan Brookbank, James Abesteh, Maya Hartman, Joanna C. Dionne, Roumen MilevList of authors in order
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https://doi.org/10.1177/07067437251394369Publisher landing page
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hybridOpen access status per OpenAlex
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https://doi.org/10.1177/07067437251394369Direct OA link when available
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0Total citation count in OpenAlex
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40Number of works referenced by this work
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| abstract_inverted_index.RCTs. | 224 |
| abstract_inverted_index.There | 36 |
| abstract_inverted_index.adult | 106 |
| abstract_inverted_index.after | 90, 110 |
| abstract_inverted_index.aimed | 70 |
| abstract_inverted_index.allow | 251 |
| abstract_inverted_index.eight | 199 |
| abstract_inverted_index.fecal | 206 |
| abstract_inverted_index.group | 179 |
| abstract_inverted_index.seven | 196 |
| abstract_inverted_index.study | 133 |
| abstract_inverted_index.using | 86, 183 |
| abstract_inverted_index.which | 170 |
| abstract_inverted_index.(RCTs) | 78 |
| abstract_inverted_index.Method | 96 |
| abstract_inverted_index.across | 221 |
| abstract_inverted_index.adults | 84, 267 |
| abstract_inverted_index.before | 88, 108 |
| abstract_inverted_index.design | 280 |
| abstract_inverted_index.either | 20 |
| abstract_inverted_index.future | 292 |
| abstract_inverted_index.number | 53 |
| abstract_inverted_index.prefer | 33 |
| abstract_inverted_index.review | 69 |
| abstract_inverted_index.trials | 55, 77 |
| abstract_inverted_index.viable | 262 |
| abstract_inverted_index.widely | 12 |
| abstract_inverted_index.years. | 66 |
| abstract_inverted_index.Central | 126 |
| abstract_inverted_index.Embase, | 122 |
| abstract_inverted_index.Results | 160 |
| abstract_inverted_index.Trials. | 130 |
| abstract_inverted_index.analyze | 72 |
| abstract_inverted_index.between | 174 |
| abstract_inverted_index.control | 76, 178 |
| abstract_inverted_index.current | 4 |
| abstract_inverted_index.design, | 215 |
| abstract_inverted_index.finding | 26 |
| abstract_inverted_index.growing | 52 |
| abstract_inverted_index.methods | 92, 112, 220 |
| abstract_inverted_index.options | 6, 265 |
| abstract_inverted_index.review, | 167 |
| abstract_inverted_index.reviews | 57 |
| abstract_inverted_index.studies | 285 |
| abstract_inverted_index.study's | 150 |
| abstract_inverted_index.subject | 60 |
| abstract_inverted_index.symptom | 182 |
| abstract_inverted_index.trials, | 191 |
| abstract_inverted_index.variety | 236 |
| abstract_inverted_index.whether | 256 |
| abstract_inverted_index.Cochrane | 125 |
| abstract_inverted_index.MEDLINE, | 121 |
| abstract_inverted_index.Register | 127 |
| abstract_inverted_index.assessed | 80, 102 |
| abstract_inverted_index.concrete | 253 |
| abstract_inverted_index.efficacy | 294 |
| abstract_inverted_index.existing | 28, 247 |
| abstract_inverted_index.findings | 151 |
| abstract_inverted_index.included | 162 |
| abstract_inverted_index.interest | 39 |
| abstract_inverted_index.measures | 239 |
| abstract_inverted_index.observed | 212 |
| abstract_inverted_index.options. | 35 |
| abstract_inverted_index.patients | 18 |
| abstract_inverted_index.possible | 231 |
| abstract_inverted_index.symptoms | 9, 82, 104 |
| abstract_inverted_index.testing. | 295 |
| abstract_inverted_index.Objective | 0 |
| abstract_inverted_index.PsycINFO, | 123 |
| abstract_inverted_index.alternate | 45 |
| abstract_inverted_index.collected | 143 |
| abstract_inverted_index.completed | 74, 98 |
| abstract_inverted_index.concluded | 171 |
| abstract_inverted_index.different | 184 |
| abstract_inverted_index.encourage | 272 |
| abstract_inverted_index.measures. | 187 |
| abstract_inverted_index.otherwise | 32 |
| abstract_inverted_index.outcomes. | 241 |
| abstract_inverted_index.probiotic | 194 |
| abstract_inverted_index.published | 61 |
| abstract_inverted_index.reporting | 282 |
| abstract_inverted_index.retrieved | 117 |
| abstract_inverted_index.symptoms. | 270 |
| abstract_inverted_index.synbiotic | 201 |
| abstract_inverted_index.synthesis | 227 |
| abstract_inverted_index.treatment | 5, 29, 264 |
| abstract_inverted_index.variation | 210 |
| abstract_inverted_index.Controlled | 129 |
| abstract_inverted_index.adequately | 22 |
| abstract_inverted_index.completed. | 159 |
| abstract_inverted_index.databases, | 120 |
| abstract_inverted_index.depression | 48, 81, 103, 269, 287 |
| abstract_inverted_index.depressive | 8, 181 |
| abstract_inverted_index.duplicate, | 147 |
| abstract_inverted_index.guidelines | 277 |
| abstract_inverted_index.increasing | 38 |
| abstract_inverted_index.microbiota | 41, 94, 114, 207, 258, 284 |
| abstract_inverted_index.modulation | 42 |
| abstract_inverted_index.prebiotic, | 198 |
| abstract_inverted_index.randomized | 75 |
| abstract_inverted_index.responding | 23 |
| abstract_inverted_index.studies’ | 214 |
| abstract_inverted_index.summarized | 153 |
| abstract_inverted_index.systematic | 68 |
| abstract_inverted_index.treatment, | 25, 49 |
| abstract_inverted_index.Conclusions | 242 |
| abstract_inverted_index.alternative | 34, 263 |
| abstract_inverted_index.composition | 217 |
| abstract_inverted_index.conclusions | 141, 254 |
| abstract_inverted_index.consumption | 219 |
| abstract_inverted_index.development | 274 |
| abstract_inverted_index.differences | 173 |
| abstract_inverted_index.possibility | 290 |
| abstract_inverted_index.significant | 172 |
| abstract_inverted_index.statistical | 226 |
| abstract_inverted_index.experiencing | 268 |
| abstract_inverted_index.intervention | 135, 176, 216, 293 |
| abstract_inverted_index.intolerable, | 30 |
| abstract_inverted_index.investigated | 13 |
| abstract_inverted_index.manipulation | 115, 259 |
| abstract_inverted_index.parallel-arm | 99 |
| abstract_inverted_index.participants | 107 |
| abstract_inverted_index.standardized | 276 |
| abstract_inverted_index.effectiveness | 2 |
| abstract_inverted_index.heterogeneity | 244 |
| abstract_inverted_index.independently | 144 |
| abstract_inverted_index.individually. | 154 |
| abstract_inverted_index.interventions | 185, 260 |
| abstract_inverted_index.manipulation. | 95 |
| abstract_inverted_index.meta-analyses | 229 |
| abstract_inverted_index.acknowledgment | 15 |
| abstract_inverted_index.interventions, | 195, 238 |
| abstract_inverted_index.characteristics | 136 |
| abstract_inverted_index.antidepressants, | 87 |
| abstract_inverted_index.transplantation. | 208 |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 9 |
| citation_normalized_percentile |