Oral misoprostol alone, compared with oral misoprostol followed by oxytocin, in women induced for hypertension of pregnancy: A multicentre randomised trial Article Swipe
Shuchita Mundle
,
Kate Lightly
,
Jill Durocher
,
Hillary Bracken
,
Moushmi Tadas
,
Seema Parvekar
,
Poonam Shivkumar
,
Brian Faragher
,
Thomas R. Easterling
,
Simon Leigh
,
M. Turner
,
Žarko Alfirević
,
Beverly Winikoff
,
Andrew Weeks
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1111/1471-0528.17839
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1111/1471-0528.17839
Objective To assess whether, in those requiring continuing uterine stimulation after cervical ripening with oral misoprostol and membrane rupture, augmentation with low‐dose oral misoprostol is superior to intravenous oxytocin. Design Open‐label, superiority randomised trial. Setting Government hospitals in India. Population Women who were induced for hypertensive disease in pregnancy and had undergone cervical ripening with oral misoprostol, but required continuing stimulation after artificial membrane rupture. Methods Participants received misoprostol (25 micrograms, orally, 2‐hourly) or titrated oxytocin through an infusion pump. All women had one‐to‐one care; fetal monitoring was conducted using a mixture of intermittent and continuous electronic fetal monitoring. Main outcome measures Caesarean birth. Results A total of 520 women were randomised and the baseline characteristics were comparable between the groups. The caesarean section rate was not reduced with the use of misoprostol (misoprostol, 84/260, 32.3%, vs oxytocin, 71/260, 27.3%; aOR 1.23; 95% CI 0.81–1.85; P = 0.33). The interval from randomisation to birth was somewhat longer with misoprostol (225 min, 207–244 min, vs 194 min, 179–210 min; aOR 1.137; 95% CI 1.023–1.264; P = 0.017). There were no cases of hyperstimulation in either arm. The rates of fetal heart rate abnormalities and maternal side effects were similar. Fewer babies in the misoprostol arm were admitted to the special care unit (10 vs 21 in the oxytocin group; aOR 0.463; 95% CI 0.203–1.058; P = 0.068) and there were no neonatal deaths in the misoprostol group, compared with three neonatal deaths in the oxytocin arm. Women's acceptability ratings were high in both study groups. Conclusions Following cervical preparation with oral misoprostol and membrane rupture, the use of continuing oral misoprostol for augmentation did not significantly reduce caesarean rates, compared with the use of oxytocin. There were no hyperstimulation or significant adverse events in either arm of the trial.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/1471-0528.17839
- OA Status
- hybrid
- Cited By
- 6
- References
- 19
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4396803685
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4396803685Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1111/1471-0528.17839Digital Object Identifier
- Title
-
Oral misoprostol alone, compared with oral misoprostol followed by oxytocin, in women induced for hypertension of pregnancy: A multicentre randomised trialWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-05-10Full publication date if available
- Authors
-
Shuchita Mundle, Kate Lightly, Jill Durocher, Hillary Bracken, Moushmi Tadas, Seema Parvekar, Poonam Shivkumar, Brian Faragher, Thomas R. Easterling, Simon Leigh, M. Turner, Žarko Alfirević, Beverly Winikoff, Andrew WeeksList of authors in order
- Landing page
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https://doi.org/10.1111/1471-0528.17839Publisher landing page
- Open access
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://doi.org/10.1111/1471-0528.17839Direct OA link when available
- Concepts
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Misoprostol, Medicine, Obstetrics, Oxytocin, Caesarean section, Pregnancy, Population, Randomized controlled trial, Abortion, Surgery, Internal medicine, Biology, Environmental health, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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6Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3, 2024: 3Per-year citation counts (last 5 years)
- References (count)
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19Number of works referenced by this work
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-
10Other works algorithmically related by OpenAlex
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| corresponding_institution_ids | https://openalex.org/I146655781 |
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