Oral Supplementation with Algal Sulphated Polysaccharide in Subjects with Inflammatory Skin Conditions: A Randomised Double-Blind Placebo-Controlled Trial and Baseline Dietary Differences Article Swipe
Lauren A. Roach
,
Barbara J. Meyer
,
J. Helen Fitton
,
Pia C. Winberg
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/md21070379
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/md21070379
We examined the effect of a dietary seaweed extract—sulfated xylorhamnoglucuronan (SXRG84)—on individuals with inflammatory skin conditions. A subgroup analysis of a larger trial was undertaken, where 44 participants with skin conditions were enrolled in a double-blind placebo-controlled crossover design. Subjects ingested either SXRG84 extract (2 g/day) for six weeks and placebo for six weeks, or vice versa. At baseline, six- and twelve-weeks inflammatory markers and the gut microbiota were assessed, as well as skin assessments using the dermatology quality of life index (DQLI), psoriasis area severity index (PASI) and visual analogue scales (VAS). There were significant differences at weeks six and twelve for pro-inflammatory cytokines IFN-γ (p = 0.041), IL-1β (p = 0.030), TNF-α (p = 0.008) and the anti-inflammatory cytokine IL-10 (p = 0.026), determined by ANCOVA. These cytokines were all significantly higher at six weeks post placebo compared to twelve weeks post placebo followed by SXRG84 treatment. A total of 23% of participants reported skin improvements, as measured by VAS (mean difference 3.1, p = 0.0005) and the DQLI score (mean difference -2.0, p = 0.049), compared to the ‘non-responders’. Thus, the ingestion of SXRG84 for 6 weeks reduced inflammatory cytokines, and a subset of participants saw improvements.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/md21070379
- https://www.mdpi.com/1660-3397/21/7/379/pdf?version=1688008516
- OA Status
- gold
- Cited By
- 10
- References
- 48
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4382403215
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4382403215Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/md21070379Digital Object Identifier
- Title
-
Oral Supplementation with Algal Sulphated Polysaccharide in Subjects with Inflammatory Skin Conditions: A Randomised Double-Blind Placebo-Controlled Trial and Baseline Dietary DifferencesWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-06-27Full publication date if available
- Authors
-
Lauren A. Roach, Barbara J. Meyer, J. Helen Fitton, Pia C. WinbergList of authors in order
- Landing page
-
https://doi.org/10.3390/md21070379Publisher landing page
- PDF URL
-
https://www.mdpi.com/1660-3397/21/7/379/pdf?version=1688008516Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1660-3397/21/7/379/pdf?version=1688008516Direct OA link when available
- Concepts
-
Placebo, Medicine, Crossover study, Dermatology Life Quality Index, Internal medicine, Gastroenterology, Psoriasis, Visual analogue scale, Ingestion, Body mass index, Randomized controlled trial, Cytokine, Immunology, Surgery, Pathology, Alternative medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
10Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 8, 2024: 2Per-year citation counts (last 5 years)
- References (count)
-
48Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4382403215 |
|---|---|
| doi | https://doi.org/10.3390/md21070379 |
| ids.doi | https://doi.org/10.3390/md21070379 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/37504910 |
| ids.openalex | https://openalex.org/W4382403215 |
| fwci | 5.04082412 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D006801 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Humans |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D011788 |
| mesh[1].is_major_topic | True |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Quality of Life |
| mesh[2].qualifier_ui | Q000188 |
| mesh[2].descriptor_ui | D011565 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | drug therapy |
| mesh[2].descriptor_name | Psoriasis |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D016207 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Cytokines |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D014409 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | Tumor Necrosis Factor-alpha |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D019587 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Dietary Supplements |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D004311 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Double-Blind Method |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D016896 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | Treatment Outcome |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D006801 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Humans |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D011788 |
| mesh[9].is_major_topic | True |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | Quality of Life |
| mesh[10].qualifier_ui | Q000188 |
| mesh[10].descriptor_ui | D011565 |
| mesh[10].is_major_topic | True |
| mesh[10].qualifier_name | drug therapy |
| mesh[10].descriptor_name | Psoriasis |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D016207 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Cytokines |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D014409 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Tumor Necrosis Factor-alpha |
| mesh[13].qualifier_ui | |
| mesh[13].descriptor_ui | D019587 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | |
| mesh[13].descriptor_name | Dietary Supplements |
| mesh[14].qualifier_ui | |
| mesh[14].descriptor_ui | D004311 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | |
| mesh[14].descriptor_name | Double-Blind Method |
| mesh[15].qualifier_ui | |
| mesh[15].descriptor_ui | D016896 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | |
| mesh[15].descriptor_name | Treatment Outcome |
| type | article |
| title | Oral Supplementation with Algal Sulphated Polysaccharide in Subjects with Inflammatory Skin Conditions: A Randomised Double-Blind Placebo-Controlled Trial and Baseline Dietary Differences |
| biblio.issue | 7 |
| biblio.volume | 21 |
| biblio.last_page | 379 |
| biblio.first_page | 379 |
| topics[0].id | https://openalex.org/T10837 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9973000288009644 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2708 |
| topics[0].subfield.display_name | Dermatology |
| topics[0].display_name | Dermatology and Skin Diseases |
| topics[1].id | https://openalex.org/T11390 |
| topics[1].field.id | https://openalex.org/fields/11 |
| topics[1].field.display_name | Agricultural and Biological Sciences |
| topics[1].score | 0.9954000115394592 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1104 |
| topics[1].subfield.display_name | Aquatic Science |
| topics[1].display_name | Seaweed-derived Bioactive Compounds |
| topics[2].id | https://openalex.org/T10469 |
| topics[2].field.id | https://openalex.org/fields/24 |
| topics[2].field.display_name | Immunology and Microbiology |
| topics[2].score | 0.9900000095367432 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2403 |
| topics[2].subfield.display_name | Immunology |
| topics[2].display_name | Psoriasis: Treatment and Pathogenesis |
| is_xpac | False |
| apc_list.value | 2500 |
| apc_list.currency | CHF |
| apc_list.value_usd | 2707 |
| apc_paid.value | 2500 |
| apc_paid.currency | CHF |
| apc_paid.value_usd | 2707 |
| concepts[0].id | https://openalex.org/C27081682 |
| concepts[0].level | 3 |
| concepts[0].score | 0.8908393383026123 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q269829 |
| concepts[0].display_name | Placebo |
| concepts[1].id | https://openalex.org/C71924100 |
| concepts[1].level | 0 |
| concepts[1].score | 0.7477580904960632 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[1].display_name | Medicine |
| concepts[2].id | https://openalex.org/C87813604 |
| concepts[2].level | 4 |
| concepts[2].score | 0.6172041893005371 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q1242899 |
| concepts[2].display_name | Crossover study |
| concepts[3].id | https://openalex.org/C2776173921 |
| concepts[3].level | 3 |
| concepts[3].score | 0.5738281011581421 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q25326609 |
| concepts[3].display_name | Dermatology Life Quality Index |
| concepts[4].id | https://openalex.org/C126322002 |
| concepts[4].level | 1 |
| concepts[4].score | 0.5703710317611694 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[4].display_name | Internal medicine |
| concepts[5].id | https://openalex.org/C90924648 |
| concepts[5].level | 1 |
| concepts[5].score | 0.5535950660705566 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q120569 |
| concepts[5].display_name | Gastroenterology |
| concepts[6].id | https://openalex.org/C2780564577 |
| concepts[6].level | 2 |
| concepts[6].score | 0.5531432628631592 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q179945 |
| concepts[6].display_name | Psoriasis |
| concepts[7].id | https://openalex.org/C14184104 |
| concepts[7].level | 2 |
| concepts[7].score | 0.5153757929801941 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q1362526 |
| concepts[7].display_name | Visual analogue scale |
| concepts[8].id | https://openalex.org/C193230392 |
| concepts[8].level | 2 |
| concepts[8].score | 0.4978978633880615 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q1663054 |
| concepts[8].display_name | Ingestion |
| concepts[9].id | https://openalex.org/C2780221984 |
| concepts[9].level | 2 |
| concepts[9].score | 0.4265287518501282 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q131191 |
| concepts[9].display_name | Body mass index |
| concepts[10].id | https://openalex.org/C168563851 |
| concepts[10].level | 2 |
| concepts[10].score | 0.42584794759750366 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q1436668 |
| concepts[10].display_name | Randomized controlled trial |
| concepts[11].id | https://openalex.org/C2778690821 |
| concepts[11].level | 2 |
| concepts[11].score | 0.4230368733406067 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q212354 |
| concepts[11].display_name | Cytokine |
| concepts[12].id | https://openalex.org/C203014093 |
| concepts[12].level | 1 |
| concepts[12].score | 0.2788357734680176 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q101929 |
| concepts[12].display_name | Immunology |
| concepts[13].id | https://openalex.org/C141071460 |
| concepts[13].level | 1 |
| concepts[13].score | 0.27848878502845764 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q40821 |
| concepts[13].display_name | Surgery |
| concepts[14].id | https://openalex.org/C142724271 |
| concepts[14].level | 1 |
| concepts[14].score | 0.0901278555393219 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q7208 |
| concepts[14].display_name | Pathology |
| concepts[15].id | https://openalex.org/C204787440 |
| concepts[15].level | 2 |
| concepts[15].score | 0.0 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q188504 |
| concepts[15].display_name | Alternative medicine |
| keywords[0].id | https://openalex.org/keywords/placebo |
| keywords[0].score | 0.8908393383026123 |
| keywords[0].display_name | Placebo |
| keywords[1].id | https://openalex.org/keywords/medicine |
| keywords[1].score | 0.7477580904960632 |
| keywords[1].display_name | Medicine |
| keywords[2].id | https://openalex.org/keywords/crossover-study |
| keywords[2].score | 0.6172041893005371 |
| keywords[2].display_name | Crossover study |
| keywords[3].id | https://openalex.org/keywords/dermatology-life-quality-index |
| keywords[3].score | 0.5738281011581421 |
| keywords[3].display_name | Dermatology Life Quality Index |
| keywords[4].id | https://openalex.org/keywords/internal-medicine |
| keywords[4].score | 0.5703710317611694 |
| keywords[4].display_name | Internal medicine |
| keywords[5].id | https://openalex.org/keywords/gastroenterology |
| keywords[5].score | 0.5535950660705566 |
| keywords[5].display_name | Gastroenterology |
| keywords[6].id | https://openalex.org/keywords/psoriasis |
| keywords[6].score | 0.5531432628631592 |
| keywords[6].display_name | Psoriasis |
| keywords[7].id | https://openalex.org/keywords/visual-analogue-scale |
| keywords[7].score | 0.5153757929801941 |
| keywords[7].display_name | Visual analogue scale |
| keywords[8].id | https://openalex.org/keywords/ingestion |
| keywords[8].score | 0.4978978633880615 |
| keywords[8].display_name | Ingestion |
| keywords[9].id | https://openalex.org/keywords/body-mass-index |
| keywords[9].score | 0.4265287518501282 |
| keywords[9].display_name | Body mass index |
| keywords[10].id | https://openalex.org/keywords/randomized-controlled-trial |
| keywords[10].score | 0.42584794759750366 |
| keywords[10].display_name | Randomized controlled trial |
| keywords[11].id | https://openalex.org/keywords/cytokine |
| keywords[11].score | 0.4230368733406067 |
| keywords[11].display_name | Cytokine |
| keywords[12].id | https://openalex.org/keywords/immunology |
| keywords[12].score | 0.2788357734680176 |
| keywords[12].display_name | Immunology |
| keywords[13].id | https://openalex.org/keywords/surgery |
| keywords[13].score | 0.27848878502845764 |
| keywords[13].display_name | Surgery |
| keywords[14].id | https://openalex.org/keywords/pathology |
| keywords[14].score | 0.0901278555393219 |
| keywords[14].display_name | Pathology |
| language | en |
| locations[0].id | doi:10.3390/md21070379 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S146563757 |
| locations[0].source.issn | 1660-3397 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1660-3397 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Marine Drugs |
| locations[0].source.host_organization | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.mdpi.com/1660-3397/21/7/379/pdf?version=1688008516 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Marine Drugs |
| locations[0].landing_page_url | https://doi.org/10.3390/md21070379 |
| locations[1].id | pmid:37504910 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Marine drugs |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/37504910 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:10381427 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | cc-by |
| locations[2].pdf_url | https://pmc.ncbi.nlm.nih.gov/articles/PMC10381427/pdf/marinedrugs-21-00379.pdf |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/cc-by |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Mar Drugs |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/10381427 |
| locations[3].id | pmh:oai:ro.uow.edu.au:test2021-14433 |
| locations[3].is_oa | False |
| locations[3].source.id | https://openalex.org/S4306400510 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | Research Online (University of Wollongong) |
| locations[3].source.host_organization | https://openalex.org/I204824540 |
| locations[3].source.host_organization_name | University of Wollongong |
| locations[3].source.host_organization_lineage | https://openalex.org/I204824540 |
| locations[3].license | |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | text |
| locations[3].license_id | |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Scopus Harvesting Series |
| locations[3].landing_page_url | https://ro.uow.edu.au/test2021/8886 |
| locations[4].id | pmh:oai:doaj.org/article:5c3e815c7f8a4cce975aae0b47cae16a |
| locations[4].is_oa | False |
| locations[4].source.id | https://openalex.org/S4306401280 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | False |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[4].source.host_organization | |
| locations[4].source.host_organization_name | |
| locations[4].license | |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | article |
| locations[4].license_id | |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | Marine Drugs, Vol 21, Iss 7, p 379 (2023) |
| locations[4].landing_page_url | https://doaj.org/article/5c3e815c7f8a4cce975aae0b47cae16a |
| locations[5].id | pmh:oai:mdpi.com:/1660-3397/21/7/379/ |
| locations[5].is_oa | True |
| locations[5].source.id | https://openalex.org/S4306400947 |
| locations[5].source.issn | |
| locations[5].source.type | repository |
| locations[5].source.is_oa | True |
| locations[5].source.issn_l | |
| locations[5].source.is_core | False |
| locations[5].source.is_in_doaj | False |
| locations[5].source.display_name | MDPI (MDPI AG) |
| locations[5].source.host_organization | https://openalex.org/I4210097602 |
| locations[5].source.host_organization_name | Multidisciplinary Digital Publishing Institute (Switzerland) |
| locations[5].source.host_organization_lineage | https://openalex.org/I4210097602 |
| locations[5].license | cc-by |
| locations[5].pdf_url | |
| locations[5].version | submittedVersion |
| locations[5].raw_type | Text |
| locations[5].license_id | https://openalex.org/licenses/cc-by |
| locations[5].is_accepted | False |
| locations[5].is_published | False |
| locations[5].raw_source_name | Marine Drugs; Volume 21; Issue 7; Pages: 379 |
| locations[5].landing_page_url | https://dx.doi.org/10.3390/md21070379 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5009002227 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-5353-7405 |
| authorships[0].author.display_name | Lauren A. Roach |
| authorships[0].countries | AU |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I204824540, https://openalex.org/I4210091629 |
| authorships[0].affiliations[0].raw_affiliation_string | School of Medical, Indigenous and Health Sciences, Molecular Horizons, Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW 2522, Australia |
| authorships[0].institutions[0].id | https://openalex.org/I4210091629 |
| authorships[0].institutions[0].ror | https://ror.org/00dt9qb91 |
| authorships[0].institutions[0].type | facility |
| authorships[0].institutions[0].lineage | https://openalex.org/I4210091629 |
| authorships[0].institutions[0].country_code | AU |
| authorships[0].institutions[0].display_name | Illawarra Health and Medical Research Institute |
| authorships[0].institutions[1].id | https://openalex.org/I204824540 |
| authorships[0].institutions[1].ror | https://ror.org/00jtmb277 |
| authorships[0].institutions[1].type | education |
| authorships[0].institutions[1].lineage | https://openalex.org/I204824540 |
| authorships[0].institutions[1].country_code | AU |
| authorships[0].institutions[1].display_name | University of Wollongong |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Lauren A. Roach |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | School of Medical, Indigenous and Health Sciences, Molecular Horizons, Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW 2522, Australia |
| authorships[1].author.id | https://openalex.org/A5088198395 |
| authorships[1].author.orcid | https://orcid.org/0000-0001-7962-7890 |
| authorships[1].author.display_name | Barbara J. Meyer |
| authorships[1].countries | AU |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I204824540, https://openalex.org/I4210091629 |
| authorships[1].affiliations[0].raw_affiliation_string | School of Medical, Indigenous and Health Sciences, Molecular Horizons, Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW 2522, Australia |
| authorships[1].institutions[0].id | https://openalex.org/I4210091629 |
| authorships[1].institutions[0].ror | https://ror.org/00dt9qb91 |
| authorships[1].institutions[0].type | facility |
| authorships[1].institutions[0].lineage | https://openalex.org/I4210091629 |
| authorships[1].institutions[0].country_code | AU |
| authorships[1].institutions[0].display_name | Illawarra Health and Medical Research Institute |
| authorships[1].institutions[1].id | https://openalex.org/I204824540 |
| authorships[1].institutions[1].ror | https://ror.org/00jtmb277 |
| authorships[1].institutions[1].type | education |
| authorships[1].institutions[1].lineage | https://openalex.org/I204824540 |
| authorships[1].institutions[1].country_code | AU |
| authorships[1].institutions[1].display_name | University of Wollongong |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Barbara J. Meyer |
| authorships[1].is_corresponding | True |
| authorships[1].raw_affiliation_strings | School of Medical, Indigenous and Health Sciences, Molecular Horizons, Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW 2522, Australia |
| authorships[2].author.id | https://openalex.org/A5055021274 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-1402-0809 |
| authorships[2].author.display_name | J. Helen Fitton |
| authorships[2].affiliations[0].raw_affiliation_string | RDadvisor, Hobart, TAS 7006, Australia |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | J. Helen Fitton |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | RDadvisor, Hobart, TAS 7006, Australia |
| authorships[3].author.id | https://openalex.org/A5032716108 |
| authorships[3].author.orcid | https://orcid.org/0000-0003-2554-4955 |
| authorships[3].author.display_name | Pia C. Winberg |
| authorships[3].affiliations[0].raw_affiliation_string | Venus Shell Systems Pty Ltd., Nowra, NSW 2540, Australia |
| authorships[3].author_position | last |
| authorships[3].raw_author_name | Pia Winberg |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Venus Shell Systems Pty Ltd., Nowra, NSW 2540, Australia |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.mdpi.com/1660-3397/21/7/379/pdf?version=1688008516 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Oral Supplementation with Algal Sulphated Polysaccharide in Subjects with Inflammatory Skin Conditions: A Randomised Double-Blind Placebo-Controlled Trial and Baseline Dietary Differences |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10837 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9973000288009644 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2708 |
| primary_topic.subfield.display_name | Dermatology |
| primary_topic.display_name | Dermatology and Skin Diseases |
| related_works | https://openalex.org/W2754068115, https://openalex.org/W2131750607, https://openalex.org/W4303456671, https://openalex.org/W43017980, https://openalex.org/W2127833079, https://openalex.org/W2154618237, https://openalex.org/W3155318579, https://openalex.org/W2077343053, https://openalex.org/W2551962319, https://openalex.org/W2073564793 |
| cited_by_count | 10 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 8 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 2 |
| locations_count | 6 |
| best_oa_location.id | doi:10.3390/md21070379 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S146563757 |
| best_oa_location.source.issn | 1660-3397 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1660-3397 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Marine Drugs |
| best_oa_location.source.host_organization | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.mdpi.com/1660-3397/21/7/379/pdf?version=1688008516 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Marine Drugs |
| best_oa_location.landing_page_url | https://doi.org/10.3390/md21070379 |
| primary_location.id | doi:10.3390/md21070379 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S146563757 |
| primary_location.source.issn | 1660-3397 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1660-3397 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Marine Drugs |
| primary_location.source.host_organization | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.mdpi.com/1660-3397/21/7/379/pdf?version=1688008516 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Marine Drugs |
| primary_location.landing_page_url | https://doi.org/10.3390/md21070379 |
| publication_date | 2023-06-27 |
| publication_year | 2023 |
| referenced_works | https://openalex.org/W3126150139, https://openalex.org/W2693088828, https://openalex.org/W2104027193, https://openalex.org/W3184764714, https://openalex.org/W2139132382, https://openalex.org/W2170624839, https://openalex.org/W2140657612, https://openalex.org/W3201764486, https://openalex.org/W2030133280, https://openalex.org/W4289525233, https://openalex.org/W2790625668, https://openalex.org/W2015027654, https://openalex.org/W6638954257, https://openalex.org/W2080090843, https://openalex.org/W191268206, https://openalex.org/W2019993336, https://openalex.org/W2056812430, https://openalex.org/W2088012516, https://openalex.org/W1974602180, https://openalex.org/W2146131641, https://openalex.org/W3045914500, https://openalex.org/W2026045997, https://openalex.org/W2058945509, https://openalex.org/W2784021868, https://openalex.org/W2058255953, https://openalex.org/W1822404940, https://openalex.org/W3112461821, https://openalex.org/W1570492102, https://openalex.org/W4210720654, https://openalex.org/W6680621517, https://openalex.org/W2003846132, https://openalex.org/W1978191515, https://openalex.org/W3045699971, https://openalex.org/W2792858861, https://openalex.org/W2770720292, https://openalex.org/W2810680026, https://openalex.org/W2884733592, https://openalex.org/W1527225321, https://openalex.org/W3174672514, https://openalex.org/W2118173539, https://openalex.org/W2768282074, https://openalex.org/W2015119817, https://openalex.org/W2085067795, https://openalex.org/W4292528167, https://openalex.org/W2050172669, https://openalex.org/W2096991001, https://openalex.org/W1849818288, https://openalex.org/W1527957830 |
| referenced_works_count | 48 |
| abstract_inverted_index.6 | 188 |
| abstract_inverted_index.= | 107, 111, 115, 123, 166, 176 |
| abstract_inverted_index.A | 16, 149 |
| abstract_inverted_index.a | 5, 20, 34, 194 |
| abstract_inverted_index.p | 165, 175 |
| abstract_inverted_index.(2 | 44 |
| abstract_inverted_index.(p | 106, 110, 114, 122 |
| abstract_inverted_index.44 | 26 |
| abstract_inverted_index.At | 57 |
| abstract_inverted_index.We | 0 |
| abstract_inverted_index.as | 70, 72, 158 |
| abstract_inverted_index.at | 97, 134 |
| abstract_inverted_index.by | 126, 146, 160 |
| abstract_inverted_index.in | 33 |
| abstract_inverted_index.of | 4, 19, 79, 151, 153, 185, 196 |
| abstract_inverted_index.or | 54 |
| abstract_inverted_index.to | 140, 179 |
| abstract_inverted_index.23% | 152 |
| abstract_inverted_index.VAS | 161 |
| abstract_inverted_index.all | 131 |
| abstract_inverted_index.and | 49, 60, 64, 88, 100, 117, 168, 193 |
| abstract_inverted_index.for | 46, 51, 102, 187 |
| abstract_inverted_index.gut | 66 |
| abstract_inverted_index.saw | 198 |
| abstract_inverted_index.six | 47, 52, 99, 135 |
| abstract_inverted_index.the | 2, 65, 76, 118, 169, 180, 183 |
| abstract_inverted_index.was | 23 |
| abstract_inverted_index.3.1, | 164 |
| abstract_inverted_index.DQLI | 170 |
| abstract_inverted_index.area | 84 |
| abstract_inverted_index.life | 80 |
| abstract_inverted_index.post | 137, 143 |
| abstract_inverted_index.six- | 59 |
| abstract_inverted_index.skin | 14, 29, 73, 156 |
| abstract_inverted_index.vice | 55 |
| abstract_inverted_index.well | 71 |
| abstract_inverted_index.were | 31, 68, 94, 130 |
| abstract_inverted_index.with | 12, 28 |
| abstract_inverted_index.(mean | 162, 172 |
| abstract_inverted_index.-2.0, | 174 |
| abstract_inverted_index.IL-10 | 121 |
| abstract_inverted_index.There | 93 |
| abstract_inverted_index.These | 128 |
| abstract_inverted_index.Thus, | 182 |
| abstract_inverted_index.index | 81, 86 |
| abstract_inverted_index.score | 171 |
| abstract_inverted_index.total | 150 |
| abstract_inverted_index.trial | 22 |
| abstract_inverted_index.using | 75 |
| abstract_inverted_index.weeks | 48, 98, 136, 142, 189 |
| abstract_inverted_index.where | 25 |
| abstract_inverted_index.(PASI) | 87 |
| abstract_inverted_index.(VAS). | 92 |
| abstract_inverted_index.0.008) | 116 |
| abstract_inverted_index.IFN-γ | 105 |
| abstract_inverted_index.IL-1β | 109 |
| abstract_inverted_index.SXRG84 | 42, 147, 186 |
| abstract_inverted_index.TNF-α | 113 |
| abstract_inverted_index.effect | 3 |
| abstract_inverted_index.either | 41 |
| abstract_inverted_index.g/day) | 45 |
| abstract_inverted_index.higher | 133 |
| abstract_inverted_index.larger | 21 |
| abstract_inverted_index.scales | 91 |
| abstract_inverted_index.subset | 195 |
| abstract_inverted_index.twelve | 101, 141 |
| abstract_inverted_index.versa. | 56 |
| abstract_inverted_index.visual | 89 |
| abstract_inverted_index.weeks, | 53 |
| abstract_inverted_index.(DQLI), | 82 |
| abstract_inverted_index.0.0005) | 167 |
| abstract_inverted_index.0.026), | 124 |
| abstract_inverted_index.0.030), | 112 |
| abstract_inverted_index.0.041), | 108 |
| abstract_inverted_index.0.049), | 177 |
| abstract_inverted_index.ANCOVA. | 127 |
| abstract_inverted_index.design. | 38 |
| abstract_inverted_index.dietary | 6 |
| abstract_inverted_index.extract | 43 |
| abstract_inverted_index.markers | 63 |
| abstract_inverted_index.placebo | 50, 138, 144 |
| abstract_inverted_index.quality | 78 |
| abstract_inverted_index.reduced | 190 |
| abstract_inverted_index.seaweed | 7 |
| abstract_inverted_index.Subjects | 39 |
| abstract_inverted_index.analogue | 90 |
| abstract_inverted_index.analysis | 18 |
| abstract_inverted_index.compared | 139, 178 |
| abstract_inverted_index.cytokine | 120 |
| abstract_inverted_index.enrolled | 32 |
| abstract_inverted_index.examined | 1 |
| abstract_inverted_index.followed | 145 |
| abstract_inverted_index.ingested | 40 |
| abstract_inverted_index.measured | 159 |
| abstract_inverted_index.reported | 155 |
| abstract_inverted_index.severity | 85 |
| abstract_inverted_index.subgroup | 17 |
| abstract_inverted_index.assessed, | 69 |
| abstract_inverted_index.baseline, | 58 |
| abstract_inverted_index.crossover | 37 |
| abstract_inverted_index.cytokines | 104, 129 |
| abstract_inverted_index.ingestion | 184 |
| abstract_inverted_index.psoriasis | 83 |
| abstract_inverted_index.conditions | 30 |
| abstract_inverted_index.cytokines, | 192 |
| abstract_inverted_index.determined | 125 |
| abstract_inverted_index.difference | 163, 173 |
| abstract_inverted_index.microbiota | 67 |
| abstract_inverted_index.treatment. | 148 |
| abstract_inverted_index.assessments | 74 |
| abstract_inverted_index.conditions. | 15 |
| abstract_inverted_index.dermatology | 77 |
| abstract_inverted_index.differences | 96 |
| abstract_inverted_index.individuals | 11 |
| abstract_inverted_index.significant | 95 |
| abstract_inverted_index.undertaken, | 24 |
| abstract_inverted_index.double-blind | 35 |
| abstract_inverted_index.inflammatory | 13, 62, 191 |
| abstract_inverted_index.participants | 27, 154, 197 |
| abstract_inverted_index.twelve-weeks | 61 |
| abstract_inverted_index.(SXRG84)—on | 10 |
| abstract_inverted_index.improvements, | 157 |
| abstract_inverted_index.improvements. | 199 |
| abstract_inverted_index.significantly | 132 |
| abstract_inverted_index.pro-inflammatory | 103 |
| abstract_inverted_index.anti-inflammatory | 119 |
| abstract_inverted_index.extract—sulfated | 8 |
| abstract_inverted_index.placebo-controlled | 36 |
| abstract_inverted_index.xylorhamnoglucuronan | 9 |
| abstract_inverted_index.‘non-responders’. | 181 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 94 |
| corresponding_author_ids | https://openalex.org/A5088198395 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 4 |
| corresponding_institution_ids | https://openalex.org/I204824540, https://openalex.org/I4210091629 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/14 |
| sustainable_development_goals[0].score | 0.6399999856948853 |
| sustainable_development_goals[0].display_name | Life below water |
| citation_normalized_percentile.value | 0.918652 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |