Organotypic Slice Cultures for Studies of Postnatal Neurogenesis Article Swipe
Adam Mosa
,
Sabrina Wang
,
Yao Tan
,
J. Martin Wojtowicz
·
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.3791/52353
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.3791/52353
Here we describe a technique for studying hippocampal postnatal neurogenesis in the rodent brain using the organotypic slice culture technique. This method maintains the characteristic topographical morphology of the hippocampus while allowing direct application of pharmacological agents to the developing hippocampal dentate gyrus. Additionally, slice cultures can be maintained for up to 4 weeks and thus, allow one to study the maturation process of newborn granule neurons. Slice cultures allow for efficient pharmacological manipulation of hippocampal slices while excluding complex variables such as uncertainties related to the deep anatomic location of the hippocampus as well as the blood brain barrier. For these reasons, we sought to optimize organotypic slice cultures specifically for postnatal neurogenesis research.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3791/52353
- https://www.jove.com/pdf/52353/organotypic-slice-cultures-for-studies-of-postnatal-neurogenesis
- OA Status
- bronze
- Cited By
- 2
- References
- 44
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2006829501
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2006829501Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3791/52353Digital Object Identifier
- Title
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Organotypic Slice Cultures for Studies of Postnatal NeurogenesisWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2015Year of publication
- Publication date
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2015-03-04Full publication date if available
- Authors
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Adam Mosa, Sabrina Wang, Yao Tan, J. Martin WojtowiczList of authors in order
- Landing page
-
https://doi.org/10.3791/52353Publisher landing page
- PDF URL
-
https://www.jove.com/pdf/52353/organotypic-slice-cultures-for-studies-of-postnatal-neurogenesisDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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bronzeOpen access status per OpenAlex
- OA URL
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https://www.jove.com/pdf/52353/organotypic-slice-cultures-for-studies-of-postnatal-neurogenesisDirect OA link when available
- Concepts
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Neurogenesis, Hippocampal formation, Dentate gyrus, Neuroscience, Hippocampus, Biology, Granule cellTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
2Total citation count in OpenAlex
- Citations by year (recent)
-
2023: 1, 2022: 1Per-year citation counts (last 5 years)
- References (count)
-
44Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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