Oridonin: A natural terpenoid having the potential to modulate apoptosis and survival signaling in cancer Article Swipe
Abhishek Chauhan
,
Hemant Joshi
,
Divya Kandari
,
Diwakar Aggarwal
,
Ritu Chauhan
,
Hardeep Singh Tuli
,
Arpit Mehrotra
,
Abhilasha Sood
,
Ujjawal Sharma
,
Darin Mansor Mathkor
,
Shafiul Haque
,
Naveen Chandra Joshi
,
Laurent Dufossé
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.phyplu.2024.100721
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.phyplu.2024.100721
Background: Oridonin, a diterpenoid lactone derived from medicinal plants, has drawn considerable attention due to its therapeutic potential, particularly its anticancer properties. It demonstrates efficacy in inducing apoptosis, suppressing cancer cell proliferation, and sensitizing cells to conventional chemotherapeutics by modulating key signaling pathways like PI3K/AKT, MAPKs, and NF-κB. Purpose: This article investigates the apoptotic mechanisms and anticancer potential of oridonin, including its modulatory effects on signaling pathways and its derivatives' enhanced efficacy against drug-resistant cancer cells. Methods: A systematic literature search was conducted using Scopus, PubMed, SpringerLink, ScienceDirect, Wiley Online, and Web of Science databases, covering the period from 2007 to 2024. Keywords such as ''Oridonin,'' ''Apoptosis,'' ''Cancer Cell Signaling Pathways,'' ''PI3K/AKT,'' ''ROS,'' and ''Nanotechnology'' were used, yielding 96 relevant studies. Results: Oridonin induces apoptosis through intrinsic and extrinsic pathways, involving ROS amplification and mitochondrial membrane potential regulation. It modulates proteins like Bax, Bcl-2, cytochrome c, and caspases, leading to DNA fragmentation. Its derivatives, such as 13p, exhibit enhanced potency by arresting the G2/M phase and targeting drug-resistant cells with minimal toxicity. Advanced nano-delivery systems and combination therapies further enhance oridonin's therapeutic potential. Conclusion: Oridonin demonstrates robust anticancer activity by modulating signaling pathways and inducing apoptosis. Its derivatives and novel delivery systems offer promising avenues for overcoming drug resistance and optimizing its therapeutic efficacy. Further research, including clinical trials, is necessary to fully harness its potential as a cancer treatment alternative.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.phyplu.2024.100721
- OA Status
- gold
- Cited By
- 3
- References
- 109
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4405730809
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4405730809Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.phyplu.2024.100721Digital Object Identifier
- Title
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Oridonin: A natural terpenoid having the potential to modulate apoptosis and survival signaling in cancerWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-12-24Full publication date if available
- Authors
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Abhishek Chauhan, Hemant Joshi, Divya Kandari, Diwakar Aggarwal, Ritu Chauhan, Hardeep Singh Tuli, Arpit Mehrotra, Abhilasha Sood, Ujjawal Sharma, Darin Mansor Mathkor, Shafiul Haque, Naveen Chandra Joshi, Laurent DufosséList of authors in order
- Landing page
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https://doi.org/10.1016/j.phyplu.2024.100721Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1016/j.phyplu.2024.100721Direct OA link when available
- Concepts
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Terpenoid, Apoptosis, Cancer, Signal transduction, Biology, Cancer research, Cell biology, Botany, Biochemistry, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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3Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3Per-year citation counts (last 5 years)
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109Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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