Origin and segregation of the human germline Article Swipe
Aracely Castillo-Venzor
,
Christopher A. Penfold
,
Michael D. Morgan
,
Walfred W. C. Tang
,
Toshihiro Kobayashi
,
Frederick C.K. Wong
,
Sophie Bergmann
,
Erin Slatery
,
Thorsten Boroviak
,
John C. Marioni
,
M. Azim Surani
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1101/2022.07.06.498671
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1101/2022.07.06.498671
Human germline-soma segregation occurs during weeks 2-3 in gastrulating embryos. While direct studies are hindered, here we investigate the dynamics of human primordial germ cell (PGCs) specification using in vitro models with temporally resolved single-cell transcriptomics and in-depth characterisation to in vivo datasets from human and non-human primates, including a 3D marmoset reference atlas. We elucidate the molecular signature for the transient gain of competence for germ cell fate during peri-implantation epiblast development. Further, we show that both the PGCs and amnion arise from transcriptionally similar TFAP2A positive progenitors at the posterior end of the embryo. Notably, genetic loss of function experiments show that TFAP2A is crucial for initiating the PGC fate without detectably affecting the amnion, and its subsequently replaced by TFAP2C as an essential component of the genetic network for PGC fate. Accordingly, amniotic cells continue to emerge from the progenitors in the posterior epiblast, but importantly, this is also a source of nascent PGCs.
Related Topics
Concepts
Epiblast
Biology
Germline
Germ cell
Cell biology
Embryo
Embryonic stem cell
Gastrulation
Cell fate determination
Genetics
Stem cell
NODAL
Embryogenesis
Transcription factor
Gene
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2022.07.06.498671
- https://www.biorxiv.org/content/biorxiv/early/2022/07/07/2022.07.06.498671.full.pdf
- OA Status
- green
- Cited By
- 3
- References
- 59
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4284880361
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4284880361Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1101/2022.07.06.498671Digital Object Identifier
- Title
-
Origin and segregation of the human germlineWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-07-07Full publication date if available
- Authors
-
Aracely Castillo-Venzor, Christopher A. Penfold, Michael D. Morgan, Walfred W. C. Tang, Toshihiro Kobayashi, Frederick C.K. Wong, Sophie Bergmann, Erin Slatery, Thorsten Boroviak, John C. Marioni, M. Azim SuraniList of authors in order
- Landing page
-
https://doi.org/10.1101/2022.07.06.498671Publisher landing page
- PDF URL
-
https://www.biorxiv.org/content/biorxiv/early/2022/07/07/2022.07.06.498671.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.biorxiv.org/content/biorxiv/early/2022/07/07/2022.07.06.498671.full.pdfDirect OA link when available
- Concepts
-
Epiblast, Biology, Germline, Germ cell, Cell biology, Embryo, Embryonic stem cell, Gastrulation, Cell fate determination, Genetics, Stem cell, NODAL, Embryogenesis, Transcription factor, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
3Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 1, 2023: 2Per-year citation counts (last 5 years)
- References (count)
-
59Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4284880361 |
|---|---|
| doi | https://doi.org/10.1101/2022.07.06.498671 |
| ids.doi | https://doi.org/10.1101/2022.07.06.498671 |
| ids.openalex | https://openalex.org/W4284880361 |
| fwci | 0.36920747 |
| type | preprint |
| title | Origin and segregation of the human germline |
| biblio.issue | |
| biblio.volume | |
| biblio.last_page | |
| biblio.first_page | |
| topics[0].id | https://openalex.org/T11289 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9972000122070312 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1312 |
| topics[0].subfield.display_name | Molecular Biology |
| topics[0].display_name | Single-cell and spatial transcriptomics |
| topics[1].id | https://openalex.org/T10505 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.996999979019165 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1312 |
| topics[1].subfield.display_name | Molecular Biology |
| topics[1].display_name | Pluripotent Stem Cells Research |
| topics[2].id | https://openalex.org/T10269 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.9937000274658203 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1312 |
| topics[2].subfield.display_name | Molecular Biology |
| topics[2].display_name | Epigenetics and DNA Methylation |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C75059768 |
| concepts[0].level | 5 |
| concepts[0].score | 0.9300754070281982 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q519516 |
| concepts[0].display_name | Epiblast |
| concepts[1].id | https://openalex.org/C86803240 |
| concepts[1].level | 0 |
| concepts[1].score | 0.8091397881507874 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[1].display_name | Biology |
| concepts[2].id | https://openalex.org/C109825262 |
| concepts[2].level | 3 |
| concepts[2].score | 0.8010995388031006 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q1139164 |
| concepts[2].display_name | Germline |
| concepts[3].id | https://openalex.org/C2779122487 |
| concepts[3].level | 3 |
| concepts[3].score | 0.5307419896125793 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q281579 |
| concepts[3].display_name | Germ cell |
| concepts[4].id | https://openalex.org/C95444343 |
| concepts[4].level | 1 |
| concepts[4].score | 0.5074121356010437 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[4].display_name | Cell biology |
| concepts[5].id | https://openalex.org/C196843134 |
| concepts[5].level | 2 |
| concepts[5].score | 0.5020411014556885 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q33196 |
| concepts[5].display_name | Embryo |
| concepts[6].id | https://openalex.org/C145103041 |
| concepts[6].level | 3 |
| concepts[6].score | 0.481444776058197 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q1151519 |
| concepts[6].display_name | Embryonic stem cell |
| concepts[7].id | https://openalex.org/C129536746 |
| concepts[7].level | 4 |
| concepts[7].score | 0.45981723070144653 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q1141026 |
| concepts[7].display_name | Gastrulation |
| concepts[8].id | https://openalex.org/C163952510 |
| concepts[8].level | 4 |
| concepts[8].score | 0.4565827250480652 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q5058196 |
| concepts[8].display_name | Cell fate determination |
| concepts[9].id | https://openalex.org/C54355233 |
| concepts[9].level | 1 |
| concepts[9].score | 0.44498729705810547 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[9].display_name | Genetics |
| concepts[10].id | https://openalex.org/C28328180 |
| concepts[10].level | 2 |
| concepts[10].score | 0.42356863617897034 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q48196 |
| concepts[10].display_name | Stem cell |
| concepts[11].id | https://openalex.org/C83330619 |
| concepts[11].level | 2 |
| concepts[11].score | 0.41120970249176025 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q21124872 |
| concepts[11].display_name | NODAL |
| concepts[12].id | https://openalex.org/C87073359 |
| concepts[12].level | 3 |
| concepts[12].score | 0.2789667844772339 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q33196 |
| concepts[12].display_name | Embryogenesis |
| concepts[13].id | https://openalex.org/C86339819 |
| concepts[13].level | 3 |
| concepts[13].score | 0.14649507403373718 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q407384 |
| concepts[13].display_name | Transcription factor |
| concepts[14].id | https://openalex.org/C104317684 |
| concepts[14].level | 2 |
| concepts[14].score | 0.1357164978981018 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[14].display_name | Gene |
| keywords[0].id | https://openalex.org/keywords/epiblast |
| keywords[0].score | 0.9300754070281982 |
| keywords[0].display_name | Epiblast |
| keywords[1].id | https://openalex.org/keywords/biology |
| keywords[1].score | 0.8091397881507874 |
| keywords[1].display_name | Biology |
| keywords[2].id | https://openalex.org/keywords/germline |
| keywords[2].score | 0.8010995388031006 |
| keywords[2].display_name | Germline |
| keywords[3].id | https://openalex.org/keywords/germ-cell |
| keywords[3].score | 0.5307419896125793 |
| keywords[3].display_name | Germ cell |
| keywords[4].id | https://openalex.org/keywords/cell-biology |
| keywords[4].score | 0.5074121356010437 |
| keywords[4].display_name | Cell biology |
| keywords[5].id | https://openalex.org/keywords/embryo |
| keywords[5].score | 0.5020411014556885 |
| keywords[5].display_name | Embryo |
| keywords[6].id | https://openalex.org/keywords/embryonic-stem-cell |
| keywords[6].score | 0.481444776058197 |
| keywords[6].display_name | Embryonic stem cell |
| keywords[7].id | https://openalex.org/keywords/gastrulation |
| keywords[7].score | 0.45981723070144653 |
| keywords[7].display_name | Gastrulation |
| keywords[8].id | https://openalex.org/keywords/cell-fate-determination |
| keywords[8].score | 0.4565827250480652 |
| keywords[8].display_name | Cell fate determination |
| keywords[9].id | https://openalex.org/keywords/genetics |
| keywords[9].score | 0.44498729705810547 |
| keywords[9].display_name | Genetics |
| keywords[10].id | https://openalex.org/keywords/stem-cell |
| keywords[10].score | 0.42356863617897034 |
| keywords[10].display_name | Stem cell |
| keywords[11].id | https://openalex.org/keywords/nodal |
| keywords[11].score | 0.41120970249176025 |
| keywords[11].display_name | NODAL |
| keywords[12].id | https://openalex.org/keywords/embryogenesis |
| keywords[12].score | 0.2789667844772339 |
| keywords[12].display_name | Embryogenesis |
| keywords[13].id | https://openalex.org/keywords/transcription-factor |
| keywords[13].score | 0.14649507403373718 |
| keywords[13].display_name | Transcription factor |
| keywords[14].id | https://openalex.org/keywords/gene |
| keywords[14].score | 0.1357164978981018 |
| keywords[14].display_name | Gene |
| language | en |
| locations[0].id | doi:10.1101/2022.07.06.498671 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4306402567 |
| locations[0].source.issn | |
| locations[0].source.type | repository |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | |
| locations[0].source.is_core | False |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| locations[0].source.host_organization | https://openalex.org/I2750212522 |
| locations[0].source.host_organization_name | Cold Spring Harbor Laboratory |
| locations[0].source.host_organization_lineage | https://openalex.org/I2750212522 |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.biorxiv.org/content/biorxiv/early/2022/07/07/2022.07.06.498671.full.pdf |
| locations[0].version | acceptedVersion |
| locations[0].raw_type | posted-content |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | False |
| locations[0].raw_source_name | |
| locations[0].landing_page_url | https://doi.org/10.1101/2022.07.06.498671 |
| indexed_in | crossref |
| authorships[0].author.id | https://openalex.org/A5005629286 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-2288-2679 |
| authorships[0].author.display_name | Aracely Castillo-Venzor |
| authorships[0].countries | GB |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I2801782436, https://openalex.org/I87048295 |
| authorships[0].affiliations[0].raw_affiliation_string | Wellcome Trust/Cancer Research UK Gurdon Institute, Henry Wellcome Building of Cancer and Developmental Biology, Cambridge, CB2 QN, UK |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I21196054 |
| authorships[0].affiliations[1].raw_affiliation_string | Wellcome - MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge Biomedical Campus, Cambridge, CB 0AW, UK |
| authorships[0].affiliations[2].institution_ids | https://openalex.org/I241749 |
| authorships[0].affiliations[2].raw_affiliation_string | Physiology, Development and Neuroscience Department, University of Cambridge, Cambridge, CB2 EL, UK |
| authorships[0].affiliations[3].institution_ids | https://openalex.org/I241749 |
| authorships[0].affiliations[3].raw_affiliation_string | Centre for Trophoblast Research, University of Cambridge, Downing Site, Cambridge CB2 3EG, United Kingdom |
| authorships[0].institutions[0].id | https://openalex.org/I2801782436 |
| authorships[0].institutions[0].ror | https://ror.org/00fp3ce15 |
| authorships[0].institutions[0].type | facility |
| authorships[0].institutions[0].lineage | https://openalex.org/I241749, https://openalex.org/I2801316944, https://openalex.org/I2801782436, https://openalex.org/I87048295 |
| authorships[0].institutions[0].country_code | GB |
| authorships[0].institutions[0].display_name | The Gurdon Institute |
| authorships[0].institutions[1].id | https://openalex.org/I241749 |
| authorships[0].institutions[1].ror | https://ror.org/013meh722 |
| authorships[0].institutions[1].type | education |
| authorships[0].institutions[1].lineage | https://openalex.org/I241749 |
| authorships[0].institutions[1].country_code | GB |
| authorships[0].institutions[1].display_name | University of Cambridge |
| authorships[0].institutions[2].id | https://openalex.org/I87048295 |
| authorships[0].institutions[2].ror | https://ror.org/029chgv08 |
| authorships[0].institutions[2].type | nonprofit |
| authorships[0].institutions[2].lineage | https://openalex.org/I87048295 |
| authorships[0].institutions[2].country_code | GB |
| authorships[0].institutions[2].display_name | Wellcome Trust |
| authorships[0].institutions[3].id | https://openalex.org/I21196054 |
| authorships[0].institutions[3].ror | https://ror.org/05nz0zp31 |
| authorships[0].institutions[3].type | facility |
| authorships[0].institutions[3].lineage | https://openalex.org/I21196054, https://openalex.org/I241749, https://openalex.org/I4210087105, https://openalex.org/I87048295, https://openalex.org/I90344618 |
| authorships[0].institutions[3].country_code | GB |
| authorships[0].institutions[3].display_name | Wellcome/MRC Cambridge Stem Cell Institute |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Aracely Castillo-Venzor |
| authorships[0].is_corresponding | True |
| authorships[0].raw_affiliation_strings | Centre for Trophoblast Research, University of Cambridge, Downing Site, Cambridge CB2 3EG, United Kingdom, Physiology, Development and Neuroscience Department, University of Cambridge, Cambridge, CB2 EL, UK, Wellcome - MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge Biomedical Campus, Cambridge, CB 0AW, UK, Wellcome Trust/Cancer Research UK Gurdon Institute, Henry Wellcome Building of Cancer and Developmental Biology, Cambridge, CB2 QN, UK |
| authorships[1].author.id | https://openalex.org/A5002599662 |
| authorships[1].author.orcid | https://orcid.org/0000-0001-5823-4705 |
| authorships[1].author.display_name | Christopher A. Penfold |
| authorships[1].countries | GB |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I241749 |
| authorships[1].affiliations[0].raw_affiliation_string | Physiology, Development and Neuroscience Department, University of Cambridge, Cambridge, CB2 EL, UK |
| authorships[1].affiliations[1].institution_ids | https://openalex.org/I2801782436, https://openalex.org/I87048295 |
| authorships[1].affiliations[1].raw_affiliation_string | Wellcome Trust/Cancer Research UK Gurdon Institute, Henry Wellcome Building of Cancer and Developmental Biology, Cambridge, CB2 QN, UK |
| authorships[1].affiliations[2].institution_ids | https://openalex.org/I21196054 |
| authorships[1].affiliations[2].raw_affiliation_string | Wellcome - MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge Biomedical Campus, Cambridge, CB 0AW, UK |
| authorships[1].affiliations[3].institution_ids | https://openalex.org/I241749 |
| authorships[1].affiliations[3].raw_affiliation_string | Centre for Trophoblast Research, University of Cambridge, Downing Site, Cambridge CB2 3EG, United Kingdom |
| authorships[1].institutions[0].id | https://openalex.org/I2801782436 |
| authorships[1].institutions[0].ror | https://ror.org/00fp3ce15 |
| authorships[1].institutions[0].type | facility |
| authorships[1].institutions[0].lineage | https://openalex.org/I241749, https://openalex.org/I2801316944, https://openalex.org/I2801782436, https://openalex.org/I87048295 |
| authorships[1].institutions[0].country_code | GB |
| authorships[1].institutions[0].display_name | The Gurdon Institute |
| authorships[1].institutions[1].id | https://openalex.org/I241749 |
| authorships[1].institutions[1].ror | https://ror.org/013meh722 |
| authorships[1].institutions[1].type | education |
| authorships[1].institutions[1].lineage | https://openalex.org/I241749 |
| authorships[1].institutions[1].country_code | GB |
| authorships[1].institutions[1].display_name | University of Cambridge |
| authorships[1].institutions[2].id | https://openalex.org/I87048295 |
| authorships[1].institutions[2].ror | https://ror.org/029chgv08 |
| authorships[1].institutions[2].type | nonprofit |
| authorships[1].institutions[2].lineage | https://openalex.org/I87048295 |
| authorships[1].institutions[2].country_code | GB |
| authorships[1].institutions[2].display_name | Wellcome Trust |
| authorships[1].institutions[3].id | https://openalex.org/I21196054 |
| authorships[1].institutions[3].ror | https://ror.org/05nz0zp31 |
| authorships[1].institutions[3].type | facility |
| authorships[1].institutions[3].lineage | https://openalex.org/I21196054, https://openalex.org/I241749, https://openalex.org/I4210087105, https://openalex.org/I87048295, https://openalex.org/I90344618 |
| authorships[1].institutions[3].country_code | GB |
| authorships[1].institutions[3].display_name | Wellcome/MRC Cambridge Stem Cell Institute |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Christopher A. Penfold |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Centre for Trophoblast Research, University of Cambridge, Downing Site, Cambridge CB2 3EG, United Kingdom, Physiology, Development and Neuroscience Department, University of Cambridge, Cambridge, CB2 EL, UK, Wellcome - MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge Biomedical Campus, Cambridge, CB 0AW, UK, Wellcome Trust/Cancer Research UK Gurdon Institute, Henry Wellcome Building of Cancer and Developmental Biology, Cambridge, CB2 QN, UK |
| authorships[2].author.id | https://openalex.org/A5053747880 |
| authorships[2].author.orcid | https://orcid.org/0000-0003-0757-0711 |
| authorships[2].author.display_name | Michael D. Morgan |
| authorships[2].countries | GB |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I241749, https://openalex.org/I2801316944 |
| authorships[2].affiliations[0].raw_affiliation_string | Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, United Kingdom |
| authorships[2].affiliations[1].institution_ids | https://openalex.org/I1303153112 |
| authorships[2].affiliations[1].raw_affiliation_string | European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, United Kingdom |
| authorships[2].institutions[0].id | https://openalex.org/I2801316944 |
| authorships[2].institutions[0].ror | https://ror.org/054225q67 |
| authorships[2].institutions[0].type | nonprofit |
| authorships[2].institutions[0].lineage | https://openalex.org/I2801316944 |
| authorships[2].institutions[0].country_code | GB |
| authorships[2].institutions[0].display_name | Cancer Research UK |
| authorships[2].institutions[1].id | https://openalex.org/I1303153112 |
| authorships[2].institutions[1].ror | https://ror.org/02catss52 |
| authorships[2].institutions[1].type | facility |
| authorships[2].institutions[1].lineage | https://openalex.org/I1303153112, https://openalex.org/I4210138560 |
| authorships[2].institutions[1].country_code | GB |
| authorships[2].institutions[1].display_name | European Bioinformatics Institute |
| authorships[2].institutions[2].id | https://openalex.org/I241749 |
| authorships[2].institutions[2].ror | https://ror.org/013meh722 |
| authorships[2].institutions[2].type | education |
| authorships[2].institutions[2].lineage | https://openalex.org/I241749 |
| authorships[2].institutions[2].country_code | GB |
| authorships[2].institutions[2].display_name | University of Cambridge |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Michael D. Morgan |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, United Kingdom, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, United Kingdom |
| authorships[3].author.id | https://openalex.org/A5033671362 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-5803-1681 |
| authorships[3].author.display_name | Walfred W. C. Tang |
| authorships[3].countries | GB |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I2801782436, https://openalex.org/I87048295 |
| authorships[3].affiliations[0].raw_affiliation_string | Wellcome Trust/Cancer Research UK Gurdon Institute, Henry Wellcome Building of Cancer and Developmental Biology, Cambridge, CB2 QN, UK |
| authorships[3].affiliations[1].institution_ids | https://openalex.org/I241749 |
| authorships[3].affiliations[1].raw_affiliation_string | Centre for Trophoblast Research, University of Cambridge, Downing Site, Cambridge CB2 3EG, United Kingdom |
| authorships[3].affiliations[2].institution_ids | https://openalex.org/I241749 |
| authorships[3].affiliations[2].raw_affiliation_string | Physiology, Development and Neuroscience Department, University of Cambridge, Cambridge, CB2 EL, UK |
| authorships[3].institutions[0].id | https://openalex.org/I2801782436 |
| authorships[3].institutions[0].ror | https://ror.org/00fp3ce15 |
| authorships[3].institutions[0].type | facility |
| authorships[3].institutions[0].lineage | https://openalex.org/I241749, https://openalex.org/I2801316944, https://openalex.org/I2801782436, https://openalex.org/I87048295 |
| authorships[3].institutions[0].country_code | GB |
| authorships[3].institutions[0].display_name | The Gurdon Institute |
| authorships[3].institutions[1].id | https://openalex.org/I241749 |
| authorships[3].institutions[1].ror | https://ror.org/013meh722 |
| authorships[3].institutions[1].type | education |
| authorships[3].institutions[1].lineage | https://openalex.org/I241749 |
| authorships[3].institutions[1].country_code | GB |
| authorships[3].institutions[1].display_name | University of Cambridge |
| authorships[3].institutions[2].id | https://openalex.org/I87048295 |
| authorships[3].institutions[2].ror | https://ror.org/029chgv08 |
| authorships[3].institutions[2].type | nonprofit |
| authorships[3].institutions[2].lineage | https://openalex.org/I87048295 |
| authorships[3].institutions[2].country_code | GB |
| authorships[3].institutions[2].display_name | Wellcome Trust |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Walfred W. C. Tang |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Centre for Trophoblast Research, University of Cambridge, Downing Site, Cambridge CB2 3EG, United Kingdom, Physiology, Development and Neuroscience Department, University of Cambridge, Cambridge, CB2 EL, UK, Wellcome Trust/Cancer Research UK Gurdon Institute, Henry Wellcome Building of Cancer and Developmental Biology, Cambridge, CB2 QN, UK |
| authorships[4].author.id | https://openalex.org/A5027939725 |
| authorships[4].author.orcid | https://orcid.org/0000-0001-8019-0008 |
| authorships[4].author.display_name | Toshihiro Kobayashi |
| authorships[4].countries | JP |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I4210145863 |
| authorships[4].affiliations[0].raw_affiliation_string | Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, Okazaki, Aichi 444-8787, Japan |
| authorships[4].affiliations[1].institution_ids | https://openalex.org/I74801974 |
| authorships[4].affiliations[1].raw_affiliation_string | Division of Mammalian Embryology, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan |
| authorships[4].institutions[0].id | https://openalex.org/I4210145863 |
| authorships[4].institutions[0].ror | https://ror.org/048v13307 |
| authorships[4].institutions[0].type | facility |
| authorships[4].institutions[0].lineage | https://openalex.org/I1319490839, https://openalex.org/I199525922, https://openalex.org/I4210145863 |
| authorships[4].institutions[0].country_code | JP |
| authorships[4].institutions[0].display_name | National Institute for Physiological Sciences |
| authorships[4].institutions[1].id | https://openalex.org/I74801974 |
| authorships[4].institutions[1].ror | https://ror.org/057zh3y96 |
| authorships[4].institutions[1].type | education |
| authorships[4].institutions[1].lineage | https://openalex.org/I74801974 |
| authorships[4].institutions[1].country_code | JP |
| authorships[4].institutions[1].display_name | The University of Tokyo |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Toshihiro Kobayashi |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, Okazaki, Aichi 444-8787, Japan, Division of Mammalian Embryology, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan |
| authorships[5].author.id | https://openalex.org/A5006663624 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-0503-4360 |
| authorships[5].author.display_name | Frederick C.K. Wong |
| authorships[5].countries | GB |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I241749 |
| authorships[5].affiliations[0].raw_affiliation_string | Centre for Trophoblast Research, University of Cambridge, Downing Site, Cambridge CB2 3EG, United Kingdom |
| authorships[5].affiliations[1].institution_ids | https://openalex.org/I2801782436, https://openalex.org/I87048295 |
| authorships[5].affiliations[1].raw_affiliation_string | Wellcome Trust/Cancer Research UK Gurdon Institute, Henry Wellcome Building of Cancer and Developmental Biology, Cambridge, CB2 QN, UK |
| authorships[5].affiliations[2].institution_ids | https://openalex.org/I241749 |
| authorships[5].affiliations[2].raw_affiliation_string | Physiology, Development and Neuroscience Department, University of Cambridge, Cambridge, CB2 EL, UK |
| authorships[5].institutions[0].id | https://openalex.org/I2801782436 |
| authorships[5].institutions[0].ror | https://ror.org/00fp3ce15 |
| authorships[5].institutions[0].type | facility |
| authorships[5].institutions[0].lineage | https://openalex.org/I241749, https://openalex.org/I2801316944, https://openalex.org/I2801782436, https://openalex.org/I87048295 |
| authorships[5].institutions[0].country_code | GB |
| authorships[5].institutions[0].display_name | The Gurdon Institute |
| authorships[5].institutions[1].id | https://openalex.org/I241749 |
| authorships[5].institutions[1].ror | https://ror.org/013meh722 |
| authorships[5].institutions[1].type | education |
| authorships[5].institutions[1].lineage | https://openalex.org/I241749 |
| authorships[5].institutions[1].country_code | GB |
| authorships[5].institutions[1].display_name | University of Cambridge |
| authorships[5].institutions[2].id | https://openalex.org/I87048295 |
| authorships[5].institutions[2].ror | https://ror.org/029chgv08 |
| authorships[5].institutions[2].type | nonprofit |
| authorships[5].institutions[2].lineage | https://openalex.org/I87048295 |
| authorships[5].institutions[2].country_code | GB |
| authorships[5].institutions[2].display_name | Wellcome Trust |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Frederick C. K. Wong |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Centre for Trophoblast Research, University of Cambridge, Downing Site, Cambridge CB2 3EG, United Kingdom, Physiology, Development and Neuroscience Department, University of Cambridge, Cambridge, CB2 EL, UK, Wellcome Trust/Cancer Research UK Gurdon Institute, Henry Wellcome Building of Cancer and Developmental Biology, Cambridge, CB2 QN, UK |
| authorships[6].author.id | https://openalex.org/A5022971471 |
| authorships[6].author.orcid | https://orcid.org/0000-0001-6018-2844 |
| authorships[6].author.display_name | Sophie Bergmann |
| authorships[6].countries | GB |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I241749 |
| authorships[6].affiliations[0].raw_affiliation_string | Physiology, Development and Neuroscience Department, University of Cambridge, Cambridge, CB2 EL, UK |
| authorships[6].affiliations[1].institution_ids | https://openalex.org/I241749 |
| authorships[6].affiliations[1].raw_affiliation_string | Centre for Trophoblast Research, University of Cambridge, Downing Site, Cambridge CB2 3EG, United Kingdom |
| authorships[6].affiliations[2].institution_ids | https://openalex.org/I21196054 |
| authorships[6].affiliations[2].raw_affiliation_string | Wellcome - MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge Biomedical Campus, Cambridge, CB 0AW, UK |
| authorships[6].institutions[0].id | https://openalex.org/I241749 |
| authorships[6].institutions[0].ror | https://ror.org/013meh722 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I241749 |
| authorships[6].institutions[0].country_code | GB |
| authorships[6].institutions[0].display_name | University of Cambridge |
| authorships[6].institutions[1].id | https://openalex.org/I21196054 |
| authorships[6].institutions[1].ror | https://ror.org/05nz0zp31 |
| authorships[6].institutions[1].type | facility |
| authorships[6].institutions[1].lineage | https://openalex.org/I21196054, https://openalex.org/I241749, https://openalex.org/I4210087105, https://openalex.org/I87048295, https://openalex.org/I90344618 |
| authorships[6].institutions[1].country_code | GB |
| authorships[6].institutions[1].display_name | Wellcome/MRC Cambridge Stem Cell Institute |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Sophie Bergmann |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Centre for Trophoblast Research, University of Cambridge, Downing Site, Cambridge CB2 3EG, United Kingdom, Physiology, Development and Neuroscience Department, University of Cambridge, Cambridge, CB2 EL, UK, Wellcome - MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge Biomedical Campus, Cambridge, CB 0AW, UK |
| authorships[7].author.id | https://openalex.org/A5031722808 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-9097-6618 |
| authorships[7].author.display_name | Erin Slatery |
| authorships[7].countries | GB |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I241749 |
| authorships[7].affiliations[0].raw_affiliation_string | Centre for Trophoblast Research, University of Cambridge, Downing Site, Cambridge CB2 3EG, United Kingdom |
| authorships[7].affiliations[1].institution_ids | https://openalex.org/I241749 |
| authorships[7].affiliations[1].raw_affiliation_string | Physiology, Development and Neuroscience Department, University of Cambridge, Cambridge, CB2 EL, UK |
| authorships[7].affiliations[2].institution_ids | https://openalex.org/I21196054 |
| authorships[7].affiliations[2].raw_affiliation_string | Wellcome - MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge Biomedical Campus, Cambridge, CB 0AW, UK |
| authorships[7].institutions[0].id | https://openalex.org/I241749 |
| authorships[7].institutions[0].ror | https://ror.org/013meh722 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I241749 |
| authorships[7].institutions[0].country_code | GB |
| authorships[7].institutions[0].display_name | University of Cambridge |
| authorships[7].institutions[1].id | https://openalex.org/I21196054 |
| authorships[7].institutions[1].ror | https://ror.org/05nz0zp31 |
| authorships[7].institutions[1].type | facility |
| authorships[7].institutions[1].lineage | https://openalex.org/I21196054, https://openalex.org/I241749, https://openalex.org/I4210087105, https://openalex.org/I87048295, https://openalex.org/I90344618 |
| authorships[7].institutions[1].country_code | GB |
| authorships[7].institutions[1].display_name | Wellcome/MRC Cambridge Stem Cell Institute |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Erin Slatery |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Centre for Trophoblast Research, University of Cambridge, Downing Site, Cambridge CB2 3EG, United Kingdom, Physiology, Development and Neuroscience Department, University of Cambridge, Cambridge, CB2 EL, UK, Wellcome - MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge Biomedical Campus, Cambridge, CB 0AW, UK |
| authorships[8].author.id | https://openalex.org/A5004722685 |
| authorships[8].author.orcid | https://orcid.org/0000-0001-8703-8949 |
| authorships[8].author.display_name | Thorsten Boroviak |
| authorships[8].countries | GB |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I241749 |
| authorships[8].affiliations[0].raw_affiliation_string | Physiology, Development and Neuroscience Department, University of Cambridge, Cambridge, CB2 EL, UK |
| authorships[8].affiliations[1].institution_ids | https://openalex.org/I241749 |
| authorships[8].affiliations[1].raw_affiliation_string | Centre for Trophoblast Research, University of Cambridge, Downing Site, Cambridge CB2 3EG, United Kingdom |
| authorships[8].affiliations[2].institution_ids | https://openalex.org/I21196054 |
| authorships[8].affiliations[2].raw_affiliation_string | Wellcome - MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge Biomedical Campus, Cambridge, CB 0AW, UK |
| authorships[8].institutions[0].id | https://openalex.org/I241749 |
| authorships[8].institutions[0].ror | https://ror.org/013meh722 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I241749 |
| authorships[8].institutions[0].country_code | GB |
| authorships[8].institutions[0].display_name | University of Cambridge |
| authorships[8].institutions[1].id | https://openalex.org/I21196054 |
| authorships[8].institutions[1].ror | https://ror.org/05nz0zp31 |
| authorships[8].institutions[1].type | facility |
| authorships[8].institutions[1].lineage | https://openalex.org/I21196054, https://openalex.org/I241749, https://openalex.org/I4210087105, https://openalex.org/I87048295, https://openalex.org/I90344618 |
| authorships[8].institutions[1].country_code | GB |
| authorships[8].institutions[1].display_name | Wellcome/MRC Cambridge Stem Cell Institute |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Thorsten E. Boroviak |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Centre for Trophoblast Research, University of Cambridge, Downing Site, Cambridge CB2 3EG, United Kingdom, Physiology, Development and Neuroscience Department, University of Cambridge, Cambridge, CB2 EL, UK, Wellcome - MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge Biomedical Campus, Cambridge, CB 0AW, UK |
| authorships[9].author.id | https://openalex.org/A5042376614 |
| authorships[9].author.orcid | https://orcid.org/0000-0001-9092-0852 |
| authorships[9].author.display_name | John C. Marioni |
| authorships[9].countries | GB |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I1303153112 |
| authorships[9].affiliations[0].raw_affiliation_string | European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, United Kingdom |
| authorships[9].affiliations[1].institution_ids | https://openalex.org/I2802476451 |
| authorships[9].affiliations[1].raw_affiliation_string | Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1RQ, United Kingdom |
| authorships[9].affiliations[2].institution_ids | https://openalex.org/I241749, https://openalex.org/I2801316944 |
| authorships[9].affiliations[2].raw_affiliation_string | Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, United Kingdom |
| authorships[9].institutions[0].id | https://openalex.org/I2801316944 |
| authorships[9].institutions[0].ror | https://ror.org/054225q67 |
| authorships[9].institutions[0].type | nonprofit |
| authorships[9].institutions[0].lineage | https://openalex.org/I2801316944 |
| authorships[9].institutions[0].country_code | GB |
| authorships[9].institutions[0].display_name | Cancer Research UK |
| authorships[9].institutions[1].id | https://openalex.org/I1303153112 |
| authorships[9].institutions[1].ror | https://ror.org/02catss52 |
| authorships[9].institutions[1].type | facility |
| authorships[9].institutions[1].lineage | https://openalex.org/I1303153112, https://openalex.org/I4210138560 |
| authorships[9].institutions[1].country_code | GB |
| authorships[9].institutions[1].display_name | European Bioinformatics Institute |
| authorships[9].institutions[2].id | https://openalex.org/I241749 |
| authorships[9].institutions[2].ror | https://ror.org/013meh722 |
| authorships[9].institutions[2].type | education |
| authorships[9].institutions[2].lineage | https://openalex.org/I241749 |
| authorships[9].institutions[2].country_code | GB |
| authorships[9].institutions[2].display_name | University of Cambridge |
| authorships[9].institutions[3].id | https://openalex.org/I2802476451 |
| authorships[9].institutions[3].ror | https://ror.org/05cy4wa09 |
| authorships[9].institutions[3].type | nonprofit |
| authorships[9].institutions[3].lineage | https://openalex.org/I2802476451, https://openalex.org/I87048295 |
| authorships[9].institutions[3].country_code | GB |
| authorships[9].institutions[3].display_name | Wellcome Sanger Institute |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | John C. Marioni |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, United Kingdom, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, United Kingdom, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1RQ, United Kingdom |
| authorships[10].author.id | https://openalex.org/A5002750540 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-8640-4318 |
| authorships[10].author.display_name | M. Azim Surani |
| authorships[10].countries | GB |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I21196054 |
| authorships[10].affiliations[0].raw_affiliation_string | Wellcome - MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge Biomedical Campus, Cambridge, CB 0AW, UK |
| authorships[10].affiliations[1].institution_ids | https://openalex.org/I241749 |
| authorships[10].affiliations[1].raw_affiliation_string | Centre for Trophoblast Research, University of Cambridge, Downing Site, Cambridge CB2 3EG, United Kingdom |
| authorships[10].affiliations[2].institution_ids | https://openalex.org/I241749 |
| authorships[10].affiliations[2].raw_affiliation_string | Physiology, Development and Neuroscience Department, University of Cambridge, Cambridge, CB2 EL, UK |
| authorships[10].affiliations[3].institution_ids | https://openalex.org/I2801782436, https://openalex.org/I87048295 |
| authorships[10].affiliations[3].raw_affiliation_string | Wellcome Trust/Cancer Research UK Gurdon Institute, Henry Wellcome Building of Cancer and Developmental Biology, Cambridge, CB2 QN, UK |
| authorships[10].institutions[0].id | https://openalex.org/I2801782436 |
| authorships[10].institutions[0].ror | https://ror.org/00fp3ce15 |
| authorships[10].institutions[0].type | facility |
| authorships[10].institutions[0].lineage | https://openalex.org/I241749, https://openalex.org/I2801316944, https://openalex.org/I2801782436, https://openalex.org/I87048295 |
| authorships[10].institutions[0].country_code | GB |
| authorships[10].institutions[0].display_name | The Gurdon Institute |
| authorships[10].institutions[1].id | https://openalex.org/I241749 |
| authorships[10].institutions[1].ror | https://ror.org/013meh722 |
| authorships[10].institutions[1].type | education |
| authorships[10].institutions[1].lineage | https://openalex.org/I241749 |
| authorships[10].institutions[1].country_code | GB |
| authorships[10].institutions[1].display_name | University of Cambridge |
| authorships[10].institutions[2].id | https://openalex.org/I87048295 |
| authorships[10].institutions[2].ror | https://ror.org/029chgv08 |
| authorships[10].institutions[2].type | nonprofit |
| authorships[10].institutions[2].lineage | https://openalex.org/I87048295 |
| authorships[10].institutions[2].country_code | GB |
| authorships[10].institutions[2].display_name | Wellcome Trust |
| authorships[10].institutions[3].id | https://openalex.org/I21196054 |
| authorships[10].institutions[3].ror | https://ror.org/05nz0zp31 |
| authorships[10].institutions[3].type | facility |
| authorships[10].institutions[3].lineage | https://openalex.org/I21196054, https://openalex.org/I241749, https://openalex.org/I4210087105, https://openalex.org/I87048295, https://openalex.org/I90344618 |
| authorships[10].institutions[3].country_code | GB |
| authorships[10].institutions[3].display_name | Wellcome/MRC Cambridge Stem Cell Institute |
| authorships[10].author_position | last |
| authorships[10].raw_author_name | M. Azim Surani |
| authorships[10].is_corresponding | True |
| authorships[10].raw_affiliation_strings | Centre for Trophoblast Research, University of Cambridge, Downing Site, Cambridge CB2 3EG, United Kingdom, Physiology, Development and Neuroscience Department, University of Cambridge, Cambridge, CB2 EL, UK, Wellcome - MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge Biomedical Campus, Cambridge, CB 0AW, UK, Wellcome Trust/Cancer Research UK Gurdon Institute, Henry Wellcome Building of Cancer and Developmental Biology, Cambridge, CB2 QN, UK |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.biorxiv.org/content/biorxiv/early/2022/07/07/2022.07.06.498671.full.pdf |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Origin and segregation of the human germline |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11289 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9972000122070312 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1312 |
| primary_topic.subfield.display_name | Molecular Biology |
| primary_topic.display_name | Single-cell and spatial transcriptomics |
| related_works | https://openalex.org/W3035912980, https://openalex.org/W1971012578, https://openalex.org/W1988818173, https://openalex.org/W83335205, https://openalex.org/W4394763867, https://openalex.org/W2898090552, https://openalex.org/W2998253198, https://openalex.org/W1956965851, https://openalex.org/W2164563970, https://openalex.org/W4283031190 |
| cited_by_count | 3 |
| counts_by_year[0].year | 2024 |
| counts_by_year[0].cited_by_count | 1 |
| counts_by_year[1].year | 2023 |
| counts_by_year[1].cited_by_count | 2 |
| locations_count | 1 |
| best_oa_location.id | doi:10.1101/2022.07.06.498671 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4306402567 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| best_oa_location.source.host_organization | https://openalex.org/I2750212522 |
| best_oa_location.source.host_organization_name | Cold Spring Harbor Laboratory |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I2750212522 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.biorxiv.org/content/biorxiv/early/2022/07/07/2022.07.06.498671.full.pdf |
| best_oa_location.version | acceptedVersion |
| best_oa_location.raw_type | posted-content |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | |
| best_oa_location.landing_page_url | https://doi.org/10.1101/2022.07.06.498671 |
| primary_location.id | doi:10.1101/2022.07.06.498671 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4306402567 |
| primary_location.source.issn | |
| primary_location.source.type | repository |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | |
| primary_location.source.is_core | False |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| primary_location.source.host_organization | https://openalex.org/I2750212522 |
| primary_location.source.host_organization_name | Cold Spring Harbor Laboratory |
| primary_location.source.host_organization_lineage | https://openalex.org/I2750212522 |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.biorxiv.org/content/biorxiv/early/2022/07/07/2022.07.06.498671.full.pdf |
| primary_location.version | acceptedVersion |
| primary_location.raw_type | posted-content |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | False |
| primary_location.raw_source_name | |
| primary_location.landing_page_url | https://doi.org/10.1101/2022.07.06.498671 |
| publication_date | 2022-07-07 |
| publication_year | 2022 |
| referenced_works | https://openalex.org/W3162324160, https://openalex.org/W2951764674, https://openalex.org/W4283015409, https://openalex.org/W2477324901, https://openalex.org/W2121758615, https://openalex.org/W3194560548, https://openalex.org/W2765511682, https://openalex.org/W2997947233, https://openalex.org/W2169456326, https://openalex.org/W2154598603, https://openalex.org/W2065731136, https://openalex.org/W2118017182, https://openalex.org/W3105358673, https://openalex.org/W2130104786, https://openalex.org/W2045911477, https://openalex.org/W2059145054, https://openalex.org/W2803045727, https://openalex.org/W3192265537, https://openalex.org/W1925655957, https://openalex.org/W2622190705, https://openalex.org/W3207946833, https://openalex.org/W2884406388, https://openalex.org/W2763867730, https://openalex.org/W3129460225, https://openalex.org/W2765099814, https://openalex.org/W2607948634, https://openalex.org/W1999913971, https://openalex.org/W2062091380, https://openalex.org/W2982474786, https://openalex.org/W2950348262, https://openalex.org/W3105545386, https://openalex.org/W3153851771, https://openalex.org/W3035090529, https://openalex.org/W2055164683, https://openalex.org/W2968912491, https://openalex.org/W4223938176, https://openalex.org/W2162504561, https://openalex.org/W2138720929, https://openalex.org/W2528428024, https://openalex.org/W2911279170, https://openalex.org/W2169231894, https://openalex.org/W2741800270, https://openalex.org/W2564061777, https://openalex.org/W6619927104, https://openalex.org/W2949177718, https://openalex.org/W3024295806, https://openalex.org/W2946129330, https://openalex.org/W2509837331, https://openalex.org/W4223498821, https://openalex.org/W2165459289, https://openalex.org/W3213709307, https://openalex.org/W2900144939, https://openalex.org/W2996524386, https://openalex.org/W3159144610, https://openalex.org/W3110090701, https://openalex.org/W2895774066, https://openalex.org/W2972524623, https://openalex.org/W2969627797, https://openalex.org/W3128071086 |
| referenced_works_count | 59 |
| abstract_inverted_index.a | 50, 153 |
| abstract_inverted_index.3D | 51 |
| abstract_inverted_index.We | 55 |
| abstract_inverted_index.an | 125 |
| abstract_inverted_index.as | 124 |
| abstract_inverted_index.at | 90 |
| abstract_inverted_index.by | 122 |
| abstract_inverted_index.in | 8, 29, 41, 144 |
| abstract_inverted_index.is | 106, 151 |
| abstract_inverted_index.of | 21, 64, 94, 100, 128, 155 |
| abstract_inverted_index.to | 40, 139 |
| abstract_inverted_index.we | 17, 75 |
| abstract_inverted_index.2-3 | 7 |
| abstract_inverted_index.PGC | 111, 133 |
| abstract_inverted_index.and | 37, 46, 81, 118 |
| abstract_inverted_index.are | 14 |
| abstract_inverted_index.but | 148 |
| abstract_inverted_index.end | 93 |
| abstract_inverted_index.for | 60, 66, 108, 132 |
| abstract_inverted_index.its | 119 |
| abstract_inverted_index.the | 19, 57, 61, 79, 91, 95, 110, 116, 129, 142, 145 |
| abstract_inverted_index.PGCs | 80 |
| abstract_inverted_index.also | 152 |
| abstract_inverted_index.both | 78 |
| abstract_inverted_index.cell | 25, 68 |
| abstract_inverted_index.fate | 69, 112 |
| abstract_inverted_index.from | 44, 84, 141 |
| abstract_inverted_index.gain | 63 |
| abstract_inverted_index.germ | 24, 67 |
| abstract_inverted_index.here | 16 |
| abstract_inverted_index.loss | 99 |
| abstract_inverted_index.show | 76, 103 |
| abstract_inverted_index.that | 77, 104 |
| abstract_inverted_index.this | 150 |
| abstract_inverted_index.vivo | 42 |
| abstract_inverted_index.with | 32 |
| abstract_inverted_index.Human | 1 |
| abstract_inverted_index.PGCs. | 157 |
| abstract_inverted_index.While | 11 |
| abstract_inverted_index.arise | 83 |
| abstract_inverted_index.cells | 137 |
| abstract_inverted_index.fate. | 134 |
| abstract_inverted_index.human | 22, 45 |
| abstract_inverted_index.using | 28 |
| abstract_inverted_index.vitro | 30 |
| abstract_inverted_index.weeks | 6 |
| abstract_inverted_index.(PGCs) | 26 |
| abstract_inverted_index.TFAP2A | 87, 105 |
| abstract_inverted_index.TFAP2C | 123 |
| abstract_inverted_index.amnion | 82 |
| abstract_inverted_index.atlas. | 54 |
| abstract_inverted_index.direct | 12 |
| abstract_inverted_index.during | 5, 70 |
| abstract_inverted_index.emerge | 140 |
| abstract_inverted_index.models | 31 |
| abstract_inverted_index.occurs | 4 |
| abstract_inverted_index.source | 154 |
| abstract_inverted_index.amnion, | 117 |
| abstract_inverted_index.crucial | 107 |
| abstract_inverted_index.embryo. | 96 |
| abstract_inverted_index.genetic | 98, 130 |
| abstract_inverted_index.nascent | 156 |
| abstract_inverted_index.network | 131 |
| abstract_inverted_index.similar | 86 |
| abstract_inverted_index.studies | 13 |
| abstract_inverted_index.without | 113 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.Further, | 74 |
| abstract_inverted_index.Notably, | 97 |
| abstract_inverted_index.amniotic | 136 |
| abstract_inverted_index.continue | 138 |
| abstract_inverted_index.datasets | 43 |
| abstract_inverted_index.dynamics | 20 |
| abstract_inverted_index.embryos. | 10 |
| abstract_inverted_index.epiblast | 72 |
| abstract_inverted_index.function | 101 |
| abstract_inverted_index.in-depth | 38 |
| abstract_inverted_index.marmoset | 52 |
| abstract_inverted_index.positive | 88 |
| abstract_inverted_index.replaced | 121 |
| abstract_inverted_index.resolved | 34 |
| abstract_inverted_index.affecting | 115 |
| abstract_inverted_index.component | 127 |
| abstract_inverted_index.elucidate | 56 |
| abstract_inverted_index.epiblast, | 147 |
| abstract_inverted_index.essential | 126 |
| abstract_inverted_index.hindered, | 15 |
| abstract_inverted_index.including | 49 |
| abstract_inverted_index.molecular | 58 |
| abstract_inverted_index.non-human | 47 |
| abstract_inverted_index.posterior | 92, 146 |
| abstract_inverted_index.primates, | 48 |
| abstract_inverted_index.reference | 53 |
| abstract_inverted_index.signature | 59 |
| abstract_inverted_index.transient | 62 |
| abstract_inverted_index.competence | 65 |
| abstract_inverted_index.detectably | 114 |
| abstract_inverted_index.initiating | 109 |
| abstract_inverted_index.primordial | 23 |
| abstract_inverted_index.temporally | 33 |
| abstract_inverted_index.experiments | 102 |
| abstract_inverted_index.investigate | 18 |
| abstract_inverted_index.progenitors | 89, 143 |
| abstract_inverted_index.segregation | 3 |
| abstract_inverted_index.single-cell | 35 |
| abstract_inverted_index.Accordingly, | 135 |
| abstract_inverted_index.development. | 73 |
| abstract_inverted_index.gastrulating | 9 |
| abstract_inverted_index.importantly, | 149 |
| abstract_inverted_index.subsequently | 120 |
| abstract_inverted_index.germline-soma | 2 |
| abstract_inverted_index.specification | 27 |
| abstract_inverted_index.transcriptomics | 36 |
| abstract_inverted_index.characterisation | 39 |
| abstract_inverted_index.peri-implantation | 71 |
| abstract_inverted_index.transcriptionally | 85 |
| cited_by_percentile_year.max | 96 |
| cited_by_percentile_year.min | 90 |
| corresponding_author_ids | https://openalex.org/A5002750540, https://openalex.org/A5005629286 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 11 |
| corresponding_institution_ids | https://openalex.org/I21196054, https://openalex.org/I241749, https://openalex.org/I2801782436, https://openalex.org/I87048295 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/15 |
| sustainable_development_goals[0].score | 0.44999998807907104 |
| sustainable_development_goals[0].display_name | Life in Land |
| citation_normalized_percentile.value | 0.5374858 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |