Origin of wiring specificity in an olfactory map: dendrite targeting of projection neurons Article Swipe
Kenneth Kin Lam Wong
,
Tongchao Li
,
Tian-Ming Fu
,
Gaoxiang Liu
,
Cheng Lyu
,
Sayeh Kohani
,
Qijing Xie
,
David J. Luginbuhl
,
Srigokul Upadhyayula
,
Eric Betzig
,
Liqun Luo
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1101/2022.12.28.522173
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1101/2022.12.28.522173
How does wiring specificity of neural maps emerge during development? Formation of the adult Drosophila olfactory glomerular map begins with patterning of projection neuron (PN) dendrites at the early pupal stage. To better understand the origin of wiring specificity of this map, we created genetic tools to systematically characterize dendrite patterning across development at PN type–specific resolution. We find that PNs use lineage and birth order combinatorially to build the initial dendritic map. Specifically, birth order directs dendrite targeting in rotating and binary manners for PNs of the anterodorsal and lateral lineages, respectively. Two-photon– and adaptive optical lattice light-sheet microscope–based time-lapse imaging reveals that PN dendrites initiate active targeting with direction-dependent branch stabilization on the timescale of seconds. Moreover, PNs that are used in both the larval and adult olfactory circuits prune their larval-specific dendrites and re-extend new dendrites simultaneously to facilitate timely olfactory map organization. Our work highlights the power and necessity of type-specific neuronal access and time-lapse imaging in identifying wiring mechanisms that underlie complex patterns of functional neural maps.
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- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2022.12.28.522173
- https://www.biorxiv.org/content/biorxiv/early/2022/12/29/2022.12.28.522173.full.pdf
- OA Status
- green
- References
- 58
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4313311945
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- OpenAlex ID
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https://openalex.org/W4313311945Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2022.12.28.522173Digital Object Identifier
- Title
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Origin of wiring specificity in an olfactory map: dendrite targeting of projection neuronsWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
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2022Year of publication
- Publication date
-
2022-12-29Full publication date if available
- Authors
-
Kenneth Kin Lam Wong, Tongchao Li, Tian-Ming Fu, Gaoxiang Liu, Cheng Lyu, Sayeh Kohani, Qijing Xie, David J. Luginbuhl, Srigokul Upadhyayula, Eric Betzig, Liqun LuoList of authors in order
- Landing page
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https://doi.org/10.1101/2022.12.28.522173Publisher landing page
- PDF URL
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https://www.biorxiv.org/content/biorxiv/early/2022/12/29/2022.12.28.522173.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.biorxiv.org/content/biorxiv/early/2022/12/29/2022.12.28.522173.full.pdfDirect OA link when available
- Concepts
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Dendrite (mathematics), Neuroscience, Biology, Soma, Biological neural network, Olfactory system, Neuron, Lineage (genetic), Anatomy, Genetics, Mathematics, Geometry, GeneTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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58Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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