Osteoblast Derived Exosomes Alleviate Radiation- Induced Hematopoietic Injury Article Swipe
Jianqi Xue
,
Ruikai Du
,
Shukuan Ling
,
Jinping Song
,
Xinxin Yuan
,
Caizhi Liu
,
Weijia Sun
,
Yuheng Li
,
Guohui Zhong
,
Yinbo Wang
,
Guodong Yuan
,
Xiaoyan Jin
,
Zizhong Liu
,
Dingsheng Zhao
,
Youyou Li
,
Wenjuan Xing
,
Yuanyuan Fan
,
Zifan Liu
,
Junjie Pan
,
Zhen Zhen
,
Yunzhang Zhao
,
Qinna Yang
,
Jianwei Li
,
Yan‐Zhong Chang
,
Yingxian Li
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fbioe.2022.850303
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fbioe.2022.850303
As hematopoietic stem cells can differentiate into all hematopoietic lineages, mitigating the damage to hematopoietic stem cells is important for recovery from overdose radiation injury. Cells in bone marrow microenvironment are essential for hematopoietic stem cells maintenance and protection, and many of the paracrine mediators have been discovered in shaping hematopoietic function. Several recent reports support exosomes as effective regulators of hematopoietic stem cells, but the role of osteoblast derived exosomes in hematopoietic stem cells protection is less understood. Here, we investigated that osteoblast derived exosomes could alleviate radiation damage to hematopoietic stem cells. We show that intravenous injection of osteoblast derived exosomes promoted WBC, lymphocyte, monocyte and hematopoietic stem cells recovery after irradiation significantly. By sequencing osteoblast derived exosomes derived miRNAs and verified in vitro , we identified miR-21 is involved in hematopoietic stem cells protection via targeting PDCD4. Collectively, our data demonstrate that osteoblast derived exosomes derived miR-21 is a resultful regulator to radio-protection of hematopoietic stem cells and provide a new strategy for reducing radiation induced hematopoietic injury.
Related Topics
Concepts
Haematopoiesis
Stem cell
Microvesicles
Hematopoietic stem cell
Cell biology
Bone marrow
Paracrine signalling
Cancer research
Stem cell factor
Osteoblast
Biology
Exosome
Immunology
In vitro
microRNA
Gene
Receptor
Biochemistry
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fbioe.2022.850303
- OA Status
- gold
- Cited By
- 6
- References
- 50
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4285744283
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4285744283Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fbioe.2022.850303Digital Object Identifier
- Title
-
Osteoblast Derived Exosomes Alleviate Radiation- Induced Hematopoietic InjuryWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-04-21Full publication date if available
- Authors
-
Jianqi Xue, Ruikai Du, Shukuan Ling, Jinping Song, Xinxin Yuan, Caizhi Liu, Weijia Sun, Yuheng Li, Guohui Zhong, Yinbo Wang, Guodong Yuan, Xiaoyan Jin, Zizhong Liu, Dingsheng Zhao, Youyou Li, Wenjuan Xing, Yuanyuan Fan, Zifan Liu, Junjie Pan, Zhen Zhen, Yunzhang Zhao, Qinna Yang, Jianwei Li, Yan‐Zhong Chang, Yingxian LiList of authors in order
- Landing page
-
https://doi.org/10.3389/fbioe.2022.850303Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.3389/fbioe.2022.850303Direct OA link when available
- Concepts
-
Haematopoiesis, Stem cell, Microvesicles, Hematopoietic stem cell, Cell biology, Bone marrow, Paracrine signalling, Cancer research, Stem cell factor, Osteoblast, Biology, Exosome, Immunology, In vitro, microRNA, Gene, Receptor, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
6Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 1, 2023: 1, 2022: 2Per-year citation counts (last 5 years)
- References (count)
-
50Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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