Osteopontin as a biomarker for COVID-19 severity and multisystem inflammatory syndrome in children: A pilot study Article Swipe
Andrew Reisner
,
Laura S. Blackwell
,
Iqbal Sayeed
,
Hannah E Myers
,
Bushra Wali
,
Stacy Heilman
,
Janet Figueroa
,
Austin Lu
,
Laila Hussaini
,
Evan J. Anderson
,
Andi L. Shane
,
Christina A. Rostad
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1177/15353702211046835
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1177/15353702211046835
This study sought to evaluate the candidacy of plasma osteopontin (OPN) as a biomarker of COVID-19 severity and multisystem inflammatory condition in children (MIS-C) in children. A retrospective analysis of 26 children (0–21 years of age) admitted to Children’s Healthcare of Atlanta with a diagnosis of COVID-19 between March 17 and May 26, 2020 was undertaken. The patients were classified into three categories based on COVID-19 severity levels: asymptomatic or minimally symptomatic (control population, admitted for other non-COVID-19 conditions), mild/moderate, and severe COVID-19. A fourth category of children met the Centers for Disease Control and Prevention's case definition for MIS-C. Residual blood samples were analyzed for OPN, a marker of inflammation using commercial ELISA kits (R&D), and results were correlated with clinical data. This study demonstrates that OPN levels are significantly elevated in children hospitalized with moderate and severe COVID-19 and MIS-C compared to OPN levels in mild/asymptomatic children. Further, OPN differentiated among clinical levels of severity in COVID-19, while other inflammatory markers including maximum erythrocyte sedimentation rate, C-reactive protein and ferritin, minimum lymphocyte and platelet counts, soluble interleukin-2R, and interleukin-6 did not. We conclude OPN is a potential biomarker of COVID-19 severity and MIS-C in children that may have future clinical utility. The specificity and positive predictive value of this marker for COVID-19 and MIS-C are areas for future larger prospective research studies.
Related Topics
Concepts
Medicine
Asymptomatic
Osteopontin
Biomarker
Erythrocyte sedimentation rate
Internal medicine
Severity of illness
Ferritin
Population
Immunology
Procalcitonin
Coronavirus disease 2019 (COVID-19)
Gastroenterology
Disease
Sepsis
Infectious disease (medical specialty)
Environmental health
Biochemistry
Chemistry
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1177/15353702211046835
- https://journals.sagepub.com/doi/pdf/10.1177/15353702211046835
- OA Status
- bronze
- Cited By
- 23
- References
- 42
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3204743715
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3204743715Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1177/15353702211046835Digital Object Identifier
- Title
-
Osteopontin as a biomarker for COVID-19 severity and multisystem inflammatory syndrome in children: A pilot studyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-09-26Full publication date if available
- Authors
-
Andrew Reisner, Laura S. Blackwell, Iqbal Sayeed, Hannah E Myers, Bushra Wali, Stacy Heilman, Janet Figueroa, Austin Lu, Laila Hussaini, Evan J. Anderson, Andi L. Shane, Christina A. RostadList of authors in order
- Landing page
-
https://doi.org/10.1177/15353702211046835Publisher landing page
- PDF URL
-
https://journals.sagepub.com/doi/pdf/10.1177/15353702211046835Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://journals.sagepub.com/doi/pdf/10.1177/15353702211046835Direct OA link when available
- Concepts
-
Medicine, Asymptomatic, Osteopontin, Biomarker, Erythrocyte sedimentation rate, Internal medicine, Severity of illness, Ferritin, Population, Immunology, Procalcitonin, Coronavirus disease 2019 (COVID-19), Gastroenterology, Disease, Sepsis, Infectious disease (medical specialty), Environmental health, Biochemistry, ChemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
23Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 11, 2023: 8, 2022: 3Per-year citation counts (last 5 years)
- References (count)
-
42Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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