Osteopontin b and c Splice isoforms in Leukemias and SolidTumors: Angiogenesis Alongside Chemoresistance Article Swipe
Akram Mirzaei
,
Saeed Mohammadi
,
Seyed H. Ghaffari
,
Marjan Yaghmaie
,
Mohammad Vaezi
,
Kamran Alimoghaddam
,
Ardeshir Ghavamzadeh
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.22034/apjcp.2018.19.3.615
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.22034/apjcp.2018.19.3.615
Osteopontin (OPN) is a glycoprotein involved in regulation of various influences on tumor progression, such as cellular proliferation, apoptosis, angiogenesis, and metastasis. Vascular endothelial growth factor (VEGF) is a secreted molecule supporting angiogenesis in various cancers through activation of the PI3K/AKT/ERK1/2 pathway. OPN and VEGF have a number of isoforms with various activities. In spite of the well-defined association between OPN and VEGF isoform expression and cure rate for solid tumors, there is a scarcity of information as to any association in leukemia. Based on the critical role of OPN in cell survival, it seems reasonable to hypothesize that OPN and VEGF isoform expression levels may impact on chemoresistance and relapse in leukemia the same as in solid tumors. Hence, the aim of our review was to explain relationships between OPN and VEGF isoforms and angiogenesis and related pathways in chemoresistance of leukemia and solid tumors. Our findings demonstrated that OPNb and OPNc alongside with VEGF isoforms and other gene pathways are involved in angiogenesis and also might promote chemoresistance and even recurrence in leukemia and solid tumors. To sum up, targeting OPN isoforms, particularly b and c, might be a novel therapeutic strategy for the treatment of leukemia as well as solid tumors.
Related Topics
Concepts
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://pubmed.ncbi.nlm.nih.gov/29580029
- OA Status
- green
- Cited By
- 18
- References
- 80
- Related Works
- 20
- OpenAlex ID
- https://openalex.org/W2788450280
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2788450280Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.22034/apjcp.2018.19.3.615Digital Object Identifier
- Title
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Osteopontin b and c Splice isoforms in Leukemias and SolidTumors: Angiogenesis Alongside ChemoresistanceWork title
- Type
-
reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2018Year of publication
- Publication date
-
2018-03-27Full publication date if available
- Authors
-
Akram Mirzaei, Saeed Mohammadi, Seyed H. Ghaffari, Marjan Yaghmaie, Mohammad Vaezi, Kamran Alimoghaddam, Ardeshir GhavamzadehList of authors in order
- Landing page
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https://pubmed.ncbi.nlm.nih.gov/29580029Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
- OA URL
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https://www.ncbi.nlm.nih.gov/pmc/articles/5980831Direct OA link when available
- Concepts
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Osteopontin, Angiogenesis, Cancer research, Gene isoform, Leukemia, Metastasis, PI3K/AKT/mTOR pathway, Biology, Immunology, Cancer, Signal transduction, Cell biology, Gene, GeneticsTop concepts (fields/topics) attached by OpenAlex
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18Total citation count in OpenAlex
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2025: 1, 2024: 2, 2023: 4, 2022: 3, 2021: 2Per-year citation counts (last 5 years)
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80Number of works referenced by this work
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20Other works algorithmically related by OpenAlex
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