Osteopontin/SPP1: a potential mediator between immune cells and vascular calcification Article Swipe
Yanli Zhao
,
Zujuan Huang
,
Limei Gao
,
Hongbo Ma
,
Rong Chang
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2024.1395596
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2024.1395596
Vascular calcification (VC) is considered a common pathological process in various vascular diseases. Accumulating studies have confirmed that VC is involved in the inflammatory response in heart disease, and SPP1+ macrophages play an important role in this process. In VC, studies have focused on the physiological and pathological functions of macrophages, such as pro-inflammatory or anti-inflammatory cytokines and pro-fibrotic vesicles. Additionally, macrophages and activated lymphocytes highly express SPP1 in atherosclerotic plaques, which promote the formation of fatty streaks and plaque development, and SPP1 is also involved in the calcification process of atherosclerotic plaques that results in heart failure, but the crosstalk between SPP1-mediated immune cells and VC has not been adequately addressed. In this review, we summarize the regulatory effect of SPP1 on VC in T cells, macrophages, and dendritic cells in different organs’ VC, which could be a potential therapeutic target for VC.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fimmu.2024.1395596
- https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1395596/pdf
- OA Status
- gold
- Cited By
- 36
- References
- 162
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4399572882
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4399572882Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fimmu.2024.1395596Digital Object Identifier
- Title
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Osteopontin/SPP1: a potential mediator between immune cells and vascular calcificationWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-06-11Full publication date if available
- Authors
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Yanli Zhao, Zujuan Huang, Limei Gao, Hongbo Ma, Rong ChangList of authors in order
- Landing page
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https://doi.org/10.3389/fimmu.2024.1395596Publisher landing page
- PDF URL
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https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1395596/pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1395596/pdfDirect OA link when available
- Concepts
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Osteopontin, Mediator, Calcification, Immune system, Medicine, Internal medicine, ImmunologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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36Total citation count in OpenAlex
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2025: 30, 2024: 6Per-year citation counts (last 5 years)
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162Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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