Outcomes and clinical implications of intranasal insulin on cognition in humans: A systematic review and meta-analysis Article Swipe
Sally Wu
,
Nicolette Stogios
,
Margaret Hahn
,
Janani Navagnanavel
,
Zahra Emami
,
Araba Chintoh
,
Philip Gerretsen
,
Ariel Graff‐Guerrero
,
Tarek K. Rajji
,
Gary Remington
,
Sri Mahavir Agarwal
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0286887
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0286887
Background Aberrant brain insulin signaling has been posited to lie at the crossroads of several metabolic and cognitive disorders. Intranasal insulin (INI) is a non-invasive approach that allows investigation and modulation of insulin signaling in the brain while limiting peripheral side effects. Objectives The objective of this systematic review and meta-analysis is to evaluate the effects of INI on cognition in diverse patient populations and healthy individuals. Methods MEDLINE, EMBASE, PsycINFO, and Cochrane CENTRAL were systematically searched from 2000 to July 2021. Eligible studies were randomized controlled trials that studied the effects of INI on cognition. Two independent reviewers determined study eligibility and extracted relevant descriptive and outcome data. Results Twenty-nine studies (pooled N = 1,726) in healthy individuals as well as those with Alzheimer’s disease (AD)/mild cognitive impairment (MCI), mental health disorders, metabolic disorders, among others, were included in the quantitative meta-analysis. Patients with AD/MCI treated with INI were more likely to show an improvement in global cognition (SMD = 0.22, 95% CI: 0.05–0.38 p = <0.00001, N = 12 studies). Among studies with healthy individuals and other patient populations, no significant effects of INI were found for global cognition. Conclusions This review demonstrates that INI may be associated with pro-cognitive benefits for global cognition, specifically for individuals with AD/MCI. Further studies are required to better understand the neurobiological mechanisms and differences in etiology to dissect the intrinsic and extrinsic factors contributing to the treatment response of INI.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1371/journal.pone.0286887
- OA Status
- gold
- Cited By
- 5
- References
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- Related Works
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- OpenAlex ID
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All OpenAlex metadata
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https://openalex.org/W4382467867Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1371/journal.pone.0286887Digital Object Identifier
- Title
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Outcomes and clinical implications of intranasal insulin on cognition in humans: A systematic review and meta-analysisWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
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2023-06-28Full publication date if available
- Authors
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Sally Wu, Nicolette Stogios, Margaret Hahn, Janani Navagnanavel, Zahra Emami, Araba Chintoh, Philip Gerretsen, Ariel Graff‐Guerrero, Tarek K. Rajji, Gary Remington, Sri Mahavir AgarwalList of authors in order
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https://doi.org/10.1371/journal.pone.0286887Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1371/journal.pone.0286887Direct OA link when available
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Meta-analysis, Cognition, PsycINFO, Medicine, Randomized controlled trial, MEDLINE, Systematic review, Bioinformatics, Clinical psychology, Internal medicine, Psychiatry, Biology, BiochemistryTop concepts (fields/topics) attached by OpenAlex
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5Total citation count in OpenAlex
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2025: 2, 2024: 3Per-year citation counts (last 5 years)
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