Outcomes of younger patients with mantle‐cell lymphoma experiencing late relapse (>24 months): the LATE‐POD study Article Swipe
Carlo Visco
,
C. Malinverni
,
E Florea
,
Ingrid Glimelius
,
Massimo Mirandola
,
Karin Ekström‐Smedby
,
Maria Chiara Tisi
,
Eva Giné
,
Alexandra Albertsson‐Lindblad
,
Ana Marín‐Niebla
,
Alice Di Rocco
,
Filipa Moita
,
Roberta Sciarra
,
Sandra Bašić‐Kinda
,
Georg Heß
,
Anke Ohler
,
Christian Winther Eskelund
,
Alessandro Re
,
I. Ferrarini
,
A. Kolstad
,
Riikka Räty
,
Francesca Maria Quaglia
,
Andrea Bernardelli
,
Toby A. Eyre
,
Greta Scapinello
,
Piero Maria Stefani
,
Lucia Morello
,
Luca Nassi
,
Stefan Hohaus
,
S Ragaini
,
Vittorio Ruggero Zilioli
,
Riccardo Bruna
,
Federica Cocito
,
Annalisa Arcari
,
Mats Jerkeman
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1002/hon.3164_348
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1002/hon.3164_348
Introduction: Patients with relapsed or refractory (R/R) mantle cell lymphoma (MCL) have poor outcome. Time to first relapse or progression (POD) has been consistently shown to be an independent predictor of survival, with patients experiencing early-POD, within 2 years since the diagnosis, representing a subgroup at greater risk of death. On the contrary, there is a paucity of large-scale treatment data on patients experiencing relapse beyond 2 years (late-POD). Methods: In this international, observational cohort study, we evaluated the outcomes amongst patients with first R/R MCL and late-POD, after upfront standard regimens including high dose cytarabine. Patients treated upfront with Bruton tyrosine kinase inhibitors (BTKi) were excluded. The primary objective was progression-free survival (PFS) of BTKi versus chemoimmunotherapy (CIT) as second line therapy. For sample size calculation 100 patients treated with drug 1 (BTKi), and 200 with drug 2 (CIT) were needed to compare PFS of drug 1 versus drug 2, assuming that CIT and BTKi would have a median PFS of 36 and 60 months, respectively. After accrual, all patients were prospectively followed-up. Overall survival (OS-2) and PFS-2 were estimated from the time of salvage therapy. Results: Overall, 386 late-POD patients were included from 10 countries. Median age was 59 (19–70), and 77% were males. Median follow-up from time of first relapse was 53 months (12–144). Overall, 114 patients had second-line BTKi (drug 1), while CIT (drug 2) was delivered to 271 patients, consisting of rituximab-bendamustine (R-B, n = 101), R-B and cytarabine (R-BAC, n = 70), or other regimens (mostly CHOP or platinum-based, n = 100). The two groups were balanced for clinicopathological features, and median time to first relapse (48 months for both). Overall, BTKi was associated with significantly longer median PFS-2 than CIT [51 versus 26 months, respectively, P = 0.0003, Figure 1], and OS-2 [88 and 56 months, P = 0.03]. The performance of BTKi and R-BAC were similar, both in terms of PFS-2 and OS-2, and significantly superior to R-B or other regimens (P = 0.0003, and P = 0.01, respectively). Multivariate Cox regression showed that ibrutinib was associated with inferior risk of death than R-B and other regimens (HR 2.41 for R-B, 2.17 for others), but similar to R-BAC. Blastoid variant, age, and time to POD as continuous variable were also independent predictors of OS-2. Nine patients with TP53 mutation had inferior OS-2 compared to TP53 wild-type patients (n = 48, P = 0.04). The research was funded by: The research was funded in part by Janssen, as part of a Clinical IIS Research Application Keywords: Aggressive B-cell non-Hodgkin lymphoma, Combination Therapies, Molecular Targeted Therapies No conflicts of interests pertinent to the abstract.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/hon.3164_348
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hon.3164_348
- OA Status
- bronze
- Cited By
- 1
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4379979745
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4379979745Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/hon.3164_348Digital Object Identifier
- Title
-
Outcomes of younger patients with mantle‐cell lymphoma experiencing late relapse (>24 months): the LATE‐POD studyWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2023Year of publication
- Publication date
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2023-06-01Full publication date if available
- Authors
-
Carlo Visco, C. Malinverni, E Florea, Ingrid Glimelius, Massimo Mirandola, Karin Ekström‐Smedby, Maria Chiara Tisi, Eva Giné, Alexandra Albertsson‐Lindblad, Ana Marín‐Niebla, Alice Di Rocco, Filipa Moita, Roberta Sciarra, Sandra Bašić‐Kinda, Georg Heß, Anke Ohler, Christian Winther Eskelund, Alessandro Re, I. Ferrarini, A. Kolstad, Riikka Räty, Francesca Maria Quaglia, Andrea Bernardelli, Toby A. Eyre, Greta Scapinello, Piero Maria Stefani, Lucia Morello, Luca Nassi, Stefan Hohaus, S Ragaini, Vittorio Ruggero Zilioli, Riccardo Bruna, Federica Cocito, Annalisa Arcari, Mats JerkemanList of authors in order
- Landing page
-
https://doi.org/10.1002/hon.3164_348Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hon.3164_348Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hon.3164_348Direct OA link when available
- Concepts
-
Medicine, Internal medicine, Mantle cell lymphoma, Discontinuation, Surgery, LymphomaTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
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2024: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.respectively). | 336 |
| abstract_inverted_index.platinum-based, | 254 |
| abstract_inverted_index.progression-free | 111 |
| abstract_inverted_index.chemoimmunotherapy | 117 |
| abstract_inverted_index.clinicopathological | 264 |
| abstract_inverted_index.rituximab-bendamustine | 236 |
| cited_by_percentile_year.max | 94 |
| cited_by_percentile_year.min | 90 |
| countries_distinct_count | 9 |
| institutions_distinct_count | 35 |
| citation_normalized_percentile.value | 0.60744479 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |