“Outlaw” mutations in quasispecies of SARS-CoV-2 inhibit replication Article Swipe
Philippe Colson
,
Jacques Fantini
,
Jérémy Delerce
,
Wahiba Bader
,
Anthony Levasseur
,
Pierre Pontarotti
,
Christian Devaux
,
Didier Raoult
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1080/22221751.2024.2368211
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1080/22221751.2024.2368211
The evolution of SARS-CoV-2, the agent of COVID-19, has been remarkable for its high mutation potential, leading to the appearance of variants. Some mutations have never appeared in the published genomes, which represent consensus, or bona fide genomes. Here we tested the hypothesis that mutations that did not appear in consensus genomes were, in fact, as frequent as the mutations that appeared during the various epidemic episodes, but were not expressed because lethal. To identify these mutations, we analysed the genomes of 90 nasopharyngeal samples and the quasispecies determined by next-generation sequencing. Mutations observed in the quasispecies and not in the consensus genomes were considered to be lethal, what we called "outlaw" mutations. Among these mutations, we analysed the 21 most frequent. Eight of these "outlaws" were in the RNA polymerase and we were able to use a structural biology model and molecular dynamics simulations to demonstrate the functional incapacity of these mutated RNA polymerases. Three other mutations affected the spike, a major protein involved in the pathogenesis of COVID-19. Overall, by analysing the SARS-CoV-2 quasispecies obtained during sequencing, this method made it possible to identify "outlaws," showing areas that could potentially become the target of treatments.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1080/22221751.2024.2368211
- https://www.tandfonline.com/doi/pdf/10.1080/22221751.2024.2368211?needAccess=true
- OA Status
- gold
- References
- 41
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4400003083
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4400003083Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1080/22221751.2024.2368211Digital Object Identifier
- Title
-
“Outlaw” mutations in quasispecies of SARS-CoV-2 inhibit replicationWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-06-25Full publication date if available
- Authors
-
Philippe Colson, Jacques Fantini, Jérémy Delerce, Wahiba Bader, Anthony Levasseur, Pierre Pontarotti, Christian Devaux, Didier RaoultList of authors in order
- Landing page
-
https://doi.org/10.1080/22221751.2024.2368211Publisher landing page
- PDF URL
-
https://www.tandfonline.com/doi/pdf/10.1080/22221751.2024.2368211?needAccess=trueDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.tandfonline.com/doi/pdf/10.1080/22221751.2024.2368211?needAccess=trueDirect OA link when available
- Concepts
-
Viral quasispecies, Biology, Genome, Genetics, Mutation, RNA, Polymerase, Mutation rate, Virology, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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41Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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