Overcoming non-small cell lung cancer radiation resistance by modulating the tumor-immune ecosystem Article Swipe
Sara Nizzero
,
Juan Carlos López Alfonso
,
Arturo Álvarez-Arenas
,
Inom Mirzaev
,
Ioannis K. Zervantonakis
,
Thomas D. Lewin
,
Anupam Rishi
,
Elena Piretto
,
Tanvi Joshi
,
Daniel N. Santiago
,
Aleksandra Karolak
,
Rae Walker
,
Florian A. Karreth
,
Javier F. Torres–Roca
,
Heiko Enderling
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1101/458372
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1101/458372
Non-small-cell lung cancer is the leading cause of cancer death worldwide. Although radiotherapy is an effective treatment choice for early-stage cases, the 5-year survival rate of patients diagnosed in late-stages remains poor. Increasing evidence suggests that the local and systemic effects of radiotherapy dependent on the induced anti-tumor immune responses. We believe that an educated adaptation of radiotherapy plans based not only on the induced immune responses, but also on the tumor-immune ecosystem composition at the beginning of treatment might increase local tumor control. We propose two different mathematical models to evaluate the potential of the tumor-immune context to inform adaptation of treatment plans with the aim of improving outcomes.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/458372
- https://www.biorxiv.org/content/biorxiv/early/2018/11/16/458372.full.pdf
- OA Status
- green
- References
- 4
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2900260487
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2900260487Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/458372Digital Object Identifier
- Title
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Overcoming non-small cell lung cancer radiation resistance by modulating the tumor-immune ecosystemWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2018Year of publication
- Publication date
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2018-11-08Full publication date if available
- Authors
-
Sara Nizzero, Juan Carlos López Alfonso, Arturo Álvarez-Arenas, Inom Mirzaev, Ioannis K. Zervantonakis, Thomas D. Lewin, Anupam Rishi, Elena Piretto, Tanvi Joshi, Daniel N. Santiago, Aleksandra Karolak, Rae Walker, Florian A. Karreth, Javier F. Torres–Roca, Heiko EnderlingList of authors in order
- Landing page
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https://doi.org/10.1101/458372Publisher landing page
- PDF URL
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https://www.biorxiv.org/content/biorxiv/early/2018/11/16/458372.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
- OA URL
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https://www.biorxiv.org/content/biorxiv/early/2018/11/16/458372.full.pdfDirect OA link when available
- Concepts
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Radiation therapy, Immune system, Context (archaeology), Lung cancer, Adaptation (eye), Cancer, Cell, Medicine, Oncology, Cancer research, Immunology, Biology, Internal medicine, Neuroscience, Paleontology, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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4Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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