Overexpression of forkhead box M1 and urokinase‑type plasminogen activator in gastric cancer is associated with cancer progression and poor prognosis Article Swipe
Jie Ma
,
Guangwei Qi
,
Ji Xu
,
Haibing Ni
,
Wulin Xu
,
Guoqing Ru
,
Zhong‐Sheng Zhao
,
Wen-juan Xu
,
Xujun He
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.3892/ol.2017.7136
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.3892/ol.2017.7136
Forkhead box M1 (FOXM1) and urokinase-type plasminogen activator (uPA) are overexpressed and associated with the pathogenesis of multiple types of human malignancy. The aims of the present study were to investigate FOXM1 and uPA expression levels in human gastric cancer using tissue microarray techniques; determining their association with clinicopathological characteristics as well as their prognostic value. Tissue microarray blocks, comprising 436 gastric cancer cases and 92 non-cancerous adjacent normal gastric tissues, were analyzed for FOXM1 and uPA protein expression levels using immunohistochemistry. The results were analyzed statistically in association with various clinicopathological characteristics and overall survival rates. FOXM1 and uPA were detected in 78.67 (343/436) and 83.26% (363/436) of cancer samples, respectively. FOXM1 and uPA were not expressed in the 92 normal gastric tissue samples. In gastric cancer, FOXM1 and uPA levels were associated with tumor size, depth of invasion, tumor-node-metastasis (TNM) stage, lymph node metastasis, vessel invasion and distant metastases. The overall survival rate was significantly decreased in patients expressing FOXM1 and uPA compared with FOXM1- and uPA-negative patients. Coxs multivariate analysis revealed that age, depth of invasion and expression levels of FOXM1 and uPA are independent predictors of survival in patients with gastric cancer. These results indicated that increased FOXM1 and uPA expression levels are associated with the invasive and metastatic processes in human gastric cancer, and inversely associated with patient prognosis. Therefore, FOXM1 and uPA may serve as novel prognostic markers independent of, but supplementing, the TNM staging system.
Related Topics
Concepts
Oncogene
Plasminogen activator
Cancer
Molecular medicine
Oncology
Cancer research
Internal medicine
Medicine
Cell cycle
Urokinase
Biology
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3892/ol.2017.7136
- http://www.spandidos-publications.com/ol/14/6/7288/download
- OA Status
- diamond
- Cited By
- 14
- References
- 45
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2761188993
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2761188993Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3892/ol.2017.7136Digital Object Identifier
- Title
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Overexpression of forkhead box M1 and urokinase‑type plasminogen activator in gastric cancer is associated with cancer progression and poor prognosisWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2017Year of publication
- Publication date
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2017-10-04Full publication date if available
- Authors
-
Jie Ma, Guangwei Qi, Ji Xu, Haibing Ni, Wulin Xu, Guoqing Ru, Zhong‐Sheng Zhao, Wen-juan Xu, Xujun HeList of authors in order
- Landing page
-
https://doi.org/10.3892/ol.2017.7136Publisher landing page
- PDF URL
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https://www.spandidos-publications.com/ol/14/6/7288/downloadDirect link to full text PDF
- Open access
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YesWhether a free full text is available
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diamondOpen access status per OpenAlex
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https://www.spandidos-publications.com/ol/14/6/7288/downloadDirect OA link when available
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Oncogene, Plasminogen activator, Cancer, Molecular medicine, Oncology, Cancer research, Internal medicine, Medicine, Cell cycle, Urokinase, BiologyTop concepts (fields/topics) attached by OpenAlex
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14Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 1, 2023: 1, 2022: 4, 2021: 1Per-year citation counts (last 5 years)
- References (count)
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45Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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