Overexpression of MMP21 and MMP28 is associated with gastric cancer progression and poor prognosis Article Swipe
Jizhen Zhang
,
Qi Pan
,
Wenhui Yan
,
Yiru Wang
,
Xujun He
,
Zhong‐Sheng Zhao
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.3892/ol.2018.8328
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.3892/ol.2018.8328
Matrix metalloproteinase (MMP)-21 and MMP-28, or epilysin, are overexpressed during the invasion and metastasis of solid tumors. The present study investigated MMP-21 and MMP-28 expression levels in human gastric cancer using tissue microarray (TMA) analysis, and determined their association with clinicopathological characteristics and patient prognosis. TMA blocks, including 436 cases of gastric cancer and 92 non-cancerous adjacent gastric tissues, were investigated using immunohistochemistry. Staining results were analyzed statistically in association with various clinicopathological characteristics and overall survival. The MMP-21 and MMP-28 positive detection rate was 31.9% (139/436) and 34.4% (150/436), respectively, in the gastric carcinoma tissue specimens. MMP-21 and MMP-28 expression levels were negative in the 92 normal gastric tissue samples. In patients with gastric cancer, positive expression of MMP-21 and MMP-28 was correlated with tumor diameter, depth of invasion, vessel invasion, lymph node and distant metastases and tumor-node-metastasis stage. The overall survival rate was significantly lower in MMP-21 and MMP-28-positive compared with negative patients. Cox multivariate analysis revealed that MMP-21 and MMP-28 levels were independent predictors of survival in patients with gastric cancer. These findings emphasize the importance of MMP-21 and MMP-28, which may serve as novel and independent prognostic markers for the invasion and metastasis of human gastric cancer.
Related Topics
Concepts
Cancer
Oncogene
Molecular medicine
Cell cycle
Medicine
Cell cycle progression
Cancer research
Oncology
Internal medicine
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3892/ol.2018.8328
- http://www.spandidos-publications.com/10.3892/ol.2018.8328/download
- OA Status
- diamond
- Cited By
- 23
- References
- 28
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2793822014
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2793822014Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3892/ol.2018.8328Digital Object Identifier
- Title
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Overexpression of MMP21 and MMP28 is associated with gastric cancer progression and poor prognosisWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2018Year of publication
- Publication date
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2018-03-22Full publication date if available
- Authors
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Jizhen Zhang, Qi Pan, Wenhui Yan, Yiru Wang, Xujun He, Zhong‐Sheng ZhaoList of authors in order
- Landing page
-
https://doi.org/10.3892/ol.2018.8328Publisher landing page
- PDF URL
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https://www.spandidos-publications.com/10.3892/ol.2018.8328/downloadDirect link to full text PDF
- Open access
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YesWhether a free full text is available
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diamondOpen access status per OpenAlex
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https://www.spandidos-publications.com/10.3892/ol.2018.8328/downloadDirect OA link when available
- Concepts
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Cancer, Oncogene, Molecular medicine, Cell cycle, Medicine, Cell cycle progression, Cancer research, Oncology, Internal medicineTop concepts (fields/topics) attached by OpenAlex
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23Total citation count in OpenAlex
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2025: 4, 2024: 1, 2023: 4, 2022: 5, 2021: 3Per-year citation counts (last 5 years)
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28Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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