Overexpression of PLK1 Molecule Following Incomplete Thermal Ablation Promotes the Proliferation and Invasion of Residual Hepatocellular Carcinoma Article Swipe
Kang Tong
,
J Q Chen
,
Weijun Wan
,
Jinshu Pang
,
Rong Wen
,
Xiu-Mei Bai
,
Lipeng Li
,
Y. Pan
,
Yun He
,
Hong Yang
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1007/s12033-024-01181-y
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1007/s12033-024-01181-y
TAT, a widely used treatment for HCC, can exacerbate the progression of residual HCC. The present study investigated the mechanism of action of PLK1 following ITA of HCC. The PLK1 levels in HCC were determined using qRT-PCR from clinical patient samples, IHC from tissue microarray, and data from globally high-throughput data and microarrays. The PLK1 levels and their effect on the biological phenotype of heat-stress HCC cells were evaluated through in vitro experiments. We detected PLK1 abnormal expression in HCC models of nude mice subjected to ITA. We detected the effects of different PLK1 expression levels on EMT pathway proteins. PLK1 exhibited an overexpression in HCC tissues with an SMD of 1.19 (3414 HCC and 3036 non-HCC tissues were included), distinguishing HCC from non-HCC effectively (AUC = 0.9). The qRT-PCR data from clinical HCC patient samples and IHC from HCC tissue microarray results also indicated an overexpressed level. In the incomplete ablation models, an increased PLK1 expression was found in both heat-stress cells and subcutaneous tumors. The upregulation of PLK1 following ITA was found to enhance the malignancy of HCC and exacerbate the proliferation, migration, and invasion of residual HCC cells, whereas PLK1 knockdown suppressed the biological malignancy of HCC cells. Meanwhile, PLK1 has different regulatory effects on various EMT pathway proteins. PLK1 promotes the progression of residual HCC by activating EMT pathway after ITA, which might provide a novel idea for the treatment and prognosis of residual HCC.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1007/s12033-024-01181-y
- OA Status
- hybrid
- Cited By
- 1
- References
- 36
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4398280837
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4398280837Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1007/s12033-024-01181-yDigital Object Identifier
- Title
-
Overexpression of PLK1 Molecule Following Incomplete Thermal Ablation Promotes the Proliferation and Invasion of Residual Hepatocellular CarcinomaWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-05-23Full publication date if available
- Authors
-
Kang Tong, J Q Chen, Weijun Wan, Jinshu Pang, Rong Wen, Xiu-Mei Bai, Lipeng Li, Y. Pan, Yun He, Hong YangList of authors in order
- Landing page
-
https://doi.org/10.1007/s12033-024-01181-yPublisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1007/s12033-024-01181-yDirect OA link when available
- Concepts
-
Gene knockdown, Hepatocellular carcinoma, Tissue microarray, PLK1, Cancer research, Immunohistochemistry, Downregulation and upregulation, Biology, Medicine, Pathology, Cancer, Cell culture, Internal medicine, Cell cycle, Genetics, Biochemistry, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1Per-year citation counts (last 5 years)
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36Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.which | 225 |
| abstract_inverted_index.action | 21 |
| abstract_inverted_index.cells, | 190 |
| abstract_inverted_index.cells. | 200 |
| abstract_inverted_index.effect | 58 |
| abstract_inverted_index.level. | 147 |
| abstract_inverted_index.levels | 30, 55, 95 |
| abstract_inverted_index.models | 80 |
| abstract_inverted_index.tissue | 43, 140 |
| abstract_inverted_index.widely | 2 |
| abstract_inverted_index.effects | 90, 206 |
| abstract_inverted_index.enhance | 175 |
| abstract_inverted_index.models, | 152 |
| abstract_inverted_index.non-HCC | 116, 123 |
| abstract_inverted_index.pathway | 98, 210, 222 |
| abstract_inverted_index.patient | 39, 134 |
| abstract_inverted_index.present | 15 |
| abstract_inverted_index.provide | 227 |
| abstract_inverted_index.qRT-PCR | 36, 129 |
| abstract_inverted_index.results | 142 |
| abstract_inverted_index.samples | 135 |
| abstract_inverted_index.through | 69 |
| abstract_inverted_index.tissues | 106, 117 |
| abstract_inverted_index.tumors. | 165 |
| abstract_inverted_index.various | 208 |
| abstract_inverted_index.whereas | 191 |
| abstract_inverted_index.ablation | 151 |
| abstract_inverted_index.abnormal | 76 |
| abstract_inverted_index.clinical | 38, 132 |
| abstract_inverted_index.detected | 74, 88 |
| abstract_inverted_index.globally | 48 |
| abstract_inverted_index.invasion | 186 |
| abstract_inverted_index.promotes | 213 |
| abstract_inverted_index.residual | 12, 188, 217, 237 |
| abstract_inverted_index.samples, | 40 |
| abstract_inverted_index.different | 92, 204 |
| abstract_inverted_index.evaluated | 68 |
| abstract_inverted_index.exhibited | 101 |
| abstract_inverted_index.following | 24, 170 |
| abstract_inverted_index.increased | 154 |
| abstract_inverted_index.indicated | 144 |
| abstract_inverted_index.knockdown | 193 |
| abstract_inverted_index.mechanism | 19 |
| abstract_inverted_index.phenotype | 62 |
| abstract_inverted_index.prognosis | 235 |
| abstract_inverted_index.proteins. | 99, 211 |
| abstract_inverted_index.subjected | 84 |
| abstract_inverted_index.treatment | 4, 233 |
| abstract_inverted_index.Meanwhile, | 201 |
| abstract_inverted_index.activating | 220 |
| abstract_inverted_index.biological | 61, 196 |
| abstract_inverted_index.determined | 34 |
| abstract_inverted_index.exacerbate | 8, 181 |
| abstract_inverted_index.expression | 77, 94, 156 |
| abstract_inverted_index.included), | 119 |
| abstract_inverted_index.incomplete | 150 |
| abstract_inverted_index.malignancy | 177, 197 |
| abstract_inverted_index.microarray | 141 |
| abstract_inverted_index.migration, | 184 |
| abstract_inverted_index.regulatory | 205 |
| abstract_inverted_index.suppressed | 194 |
| abstract_inverted_index.effectively | 124 |
| abstract_inverted_index.heat-stress | 64, 161 |
| abstract_inverted_index.microarray, | 44 |
| abstract_inverted_index.progression | 10, 215 |
| abstract_inverted_index.experiments. | 72 |
| abstract_inverted_index.investigated | 17 |
| abstract_inverted_index.microarrays. | 52 |
| abstract_inverted_index.subcutaneous | 164 |
| abstract_inverted_index.upregulation | 167 |
| abstract_inverted_index.overexpressed | 146 |
| abstract_inverted_index.distinguishing | 120 |
| abstract_inverted_index.overexpression | 103 |
| abstract_inverted_index.proliferation, | 183 |
| abstract_inverted_index.high-throughput | 49 |
| cited_by_percentile_year.max | 95 |
| cited_by_percentile_year.min | 91 |
| corresponding_author_ids | https://openalex.org/A5055693358 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 10 |
| corresponding_institution_ids | https://openalex.org/I160354086 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.5600000023841858 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.59568704 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |