Overweight as a Causal Factor Contributing to Better Survival at the Oldest Old Ages: A Mendelian Randomization Study Article Swipe
Hongzhe Duan
,
Konstantin G. Arbeev
,
Rachel Holmes
,
Olivia Bagley
,
Deqing Wu
,
Igor Akushevich
,
Nicole Schupf
,
Anatoliy I. Yashin
,
Svetlana Ukraintseva
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.05.30.24308211
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.05.30.24308211
Overweight, defined by a body mass index (BMI) between 25 and 30, has been associated with enhanced survival among older adults in some studies. However, whether being overweight is causally linked to longevity remains unclear. To investigate this, we conducted a Mendelian randomization (MR) study of lifespan 85+ years, using overweight as an exposure variable and data from the Health and Retirement Study and the Long Life Family Study. An essential aspect of MR involves selecting appropriate single-nucleotide polymorphisms (SNPs) as instrumental variables (IVs). This is challenging due to the limited number of SNP candidates within biologically relevant genes that can satisfy all necessary assumptions and criteria. To address this challenge, we employed a novel strategy of creating additional IVs by pairing SNPs between candidate genes. This strategy allowed us to expand the pool of IV candidates with new 'composite' SNPs derived from eight candidate obesity genes. Our study found that being overweight between ages 75 and 85, compared to having a normal weight (BMI 18.5-24.9), significantly contributes to improved survival beyond age 85. Results of this MR study thus support a causal relationship between overweight and longevity in older adults.
Related Topics
Concepts
Mendelian randomization
Overweight
Single-nucleotide polymorphism
Longevity
Body mass index
Obesity
Mendelian inheritance
SNP
Candidate gene
Instrumental variable
Medicine
Gerontology
Demography
Genetics
Biology
Gene
Internal medicine
Genotype
Genetic variants
Computer science
Sociology
Machine learning
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2024.05.30.24308211
- https://www.medrxiv.org/content/medrxiv/early/2024/05/31/2024.05.30.24308211.full.pdf
- OA Status
- green
- References
- 43
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4399268698
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4399268698Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1101/2024.05.30.24308211Digital Object Identifier
- Title
-
Overweight as a Causal Factor Contributing to Better Survival at the Oldest Old Ages: A Mendelian Randomization StudyWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-05-31Full publication date if available
- Authors
-
Hongzhe Duan, Konstantin G. Arbeev, Rachel Holmes, Olivia Bagley, Deqing Wu, Igor Akushevich, Nicole Schupf, Anatoliy I. Yashin, Svetlana UkraintsevaList of authors in order
- Landing page
-
https://doi.org/10.1101/2024.05.30.24308211Publisher landing page
- PDF URL
-
https://www.medrxiv.org/content/medrxiv/early/2024/05/31/2024.05.30.24308211.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.medrxiv.org/content/medrxiv/early/2024/05/31/2024.05.30.24308211.full.pdfDirect OA link when available
- Concepts
-
Mendelian randomization, Overweight, Single-nucleotide polymorphism, Longevity, Body mass index, Obesity, Mendelian inheritance, SNP, Candidate gene, Instrumental variable, Medicine, Gerontology, Demography, Genetics, Biology, Gene, Internal medicine, Genotype, Genetic variants, Computer science, Sociology, Machine learningTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
43Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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