Oxygen-Binding Sites of Enriched Gold Nanoclusters for Capturing Mitochondrial Reverse Electrons Article Swipe
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· 2024
· Open Access
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· DOI: https://doi.org/10.1021/acs.nanolett.4c02331
Reverse electron transfer (RET), an abnormal backward flow of electrons from complexes III/IV to II/I of mitochondria, causes the overproduction of a reduced-type CoQ to boost downstream production of mitochondrial superoxide anions that leads to ischemia-reperfusion injury (IRI) to organs. Herein, we studied low-coordinated gold nanoclusters (AuNCs) with abundant oxygen-binding sites to form an electron-demanding trapper that allowed rapid capture of electrons to compensate for the CoQ/CoQH2 imbalance during RET. The AuNCs were composed of only eight gold atoms that formed a Cs-symmetrical configuration with all gold atoms exposed on the edge site. The geometry and atomic configuration enhance oxygen intercalation to attain a d-band electron deficiency in frontier orbitals, forming an unusually high oxidation state for rapid mitochondrial reverse electron capture under a transient imbalance of CoQ/CoQH2 redox cycles. Using hepatic IRI cells/animals, we corroborated that the CoQ-like AuNCs prevent inflammation and liver damage from IRI via recovery of the mitochondrial function.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1021/acs.nanolett.4c02331
- OA Status
- hybrid
- Cited By
- 2
- References
- 41
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4401991343
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4401991343Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1021/acs.nanolett.4c02331Digital Object Identifier
- Title
-
Oxygen-Binding Sites of Enriched Gold Nanoclusters for Capturing Mitochondrial Reverse ElectronsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-08-29Full publication date if available
- Authors
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Fang‐Hsuean Liao, Shuping Chen, Chun‐Nien Yao, Te‐Haw Wu, Meng-Ting Liu, Chia‐Shuo Hsu, Hao Ming Chen, Shu‐Yi LinList of authors in order
- Landing page
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https://doi.org/10.1021/acs.nanolett.4c02331Publisher landing page
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://doi.org/10.1021/acs.nanolett.4c02331Direct OA link when available
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Nanoclusters, Oxygen, Electron, Chemical physics, Nanotechnology, Chemistry, Materials science, Photochemistry, Physics, Organic chemistry, Quantum mechanicsTop concepts (fields/topics) attached by OpenAlex
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2Total citation count in OpenAlex
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2025: 2Per-year citation counts (last 5 years)
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41Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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