Oxygen concentration modulates colibactin production Article Swipe
Nadège Bossuet‐Greif
,
Cécile Guyonnet
,
Camille V. Chagneau
,
Min Tang-Fichaux
,
Marie Pénary
,
Dorian Loubet
,
Priscilla Branchu
,
Éric Oswald
,
Jean‐Philippe Nougayrède
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1080/19490976.2023.2222437
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1080/19490976.2023.2222437
Up to 25% of the E. coli strains isolated from the feces of healthy humans harbor the pks genomic island encoding the synthesis of colibactin, a genotoxic metabolite. Evidence is accumulating for an etiologic role of colibactin in colorectal cancer. Little is known about the conditions of expression of colibactin in the gut. The intestine is characterized by a unique oxygenation profile, with a steep gradient between the physiological hypoxic epithelial surface and the anaerobic lumen, which favors the dominance of obligate anaerobes. Here, we report that colibactin production is maximal under anoxic conditions and decreases with increased oxygen concentration. We show that the aerobic respiration control (ArcA) positively regulates colibactin production and genotoxicity of pks+ E. coli in response to oxygen availability. Thus, colibactin synthesis is inhibited by oxygen, indicating that the pks biosynthetic pathway is adapted to the anoxic intestinal lumen and to the hypoxic infected or tumor tissue.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1080/19490976.2023.2222437
- https://www.tandfonline.com/doi/pdf/10.1080/19490976.2023.2222437?needAccess=true&role=button
- OA Status
- gold
- Cited By
- 13
- References
- 54
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4380577761
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4380577761Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1080/19490976.2023.2222437Digital Object Identifier
- Title
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Oxygen concentration modulates colibactin productionWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
-
2023-06-13Full publication date if available
- Authors
-
Nadège Bossuet‐Greif, Cécile Guyonnet, Camille V. Chagneau, Min Tang-Fichaux, Marie Pénary, Dorian Loubet, Priscilla Branchu, Éric Oswald, Jean‐Philippe NougayrèdeList of authors in order
- Landing page
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https://doi.org/10.1080/19490976.2023.2222437Publisher landing page
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https://www.tandfonline.com/doi/pdf/10.1080/19490976.2023.2222437?needAccess=true&role=buttonDirect link to full text PDF
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.tandfonline.com/doi/pdf/10.1080/19490976.2023.2222437?needAccess=true&role=buttonDirect OA link when available
- Concepts
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Biology, Anoxic waters, Obligate anaerobe, Microbiology, Metabolite, Secondary metabolite, Obligate, Transcriptome, Biochemistry, Bacteria, Genetics, Gene, Ecology, Gene expressionTop concepts (fields/topics) attached by OpenAlex
- Cited by
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13Total citation count in OpenAlex
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2025: 5, 2024: 8Per-year citation counts (last 5 years)
- References (count)
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54Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| cited_by_percentile_year.min | 98 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 9 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/14 |
| sustainable_development_goals[0].score | 0.800000011920929 |
| sustainable_development_goals[0].display_name | Life below water |
| citation_normalized_percentile.value | 0.88832341 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |