Oxygen-sensitive interneurons exhibit increased activity and GABA release during ROS scavenging in the cerebral cortex of the western painted turtle Article Swipe
Peter John Hawrysh
,
Leslie T. Buck
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1152/jn.00104.2019
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1152/jn.00104.2019
The western painted turtle ( Chrysemys picta bellii) has the unique ability of surviving several months in the absence of oxygen, which is termed anoxia. One major protective strategy that the turtle employs during anoxia is a reduction in neuronal electrical activity, which may result from a natural reduction in reactive oxygen species (ROS). We previously linked a reduction in ROS levels to an increase in γ-amino butyric acid (GABA) receptor currents. The purpose of this study is to understand how fast-spiking, GABA-releasing neurons respond to reductions in ROS and how this affects GABA release. Using a fluorescence-coupled enzymatic microplate assay for GABA, we found that anoxia, the ROS scavenger N-(2-mercaptopriopionyl)glycine (MPG), or the mitochondria-specific ROS scavenger MitoTEMPO resulted in a 2.5-, 2.0-, and 2.5-fold increase in extracellular GABA concentration, respectively. This phenomenon could be blocked with TTX, indicating that it is activity dependent. Using whole cell patch-clamping techniques, we found that fast-spiking, burst-firing GABAergic turtle neurons increase the duration and number of action potentials per burst by 26% and 42%, respectively, in response to ROS scavenging via MPG. These results suggest that the reduction in mitochondrially produced ROS that occurs during anoxia leads to increased GABA release, which promotes postsynaptic inhibitory activity through activation of GABA receptors. NEW & NOTEWORTHY This is a novel study examining the response of cerebral cortical stellate interneurons to anoxia and mitochondrial reactive oxygen species (ROS) scavenging with MitoTEMPO. Under both conditions burst firing increases in these cells, and we show that extracellular GABA release increases in the presence of the ROS scavenger. We conclude that in the anoxia-tolerant painted turtle brain, a decrease in ROS levels is an important low oxygen signal.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1152/jn.00104.2019
- https://journals.physiology.org/doi/pdf/10.1152/jn.00104.2019
- OA Status
- bronze
- Cited By
- 10
- References
- 61
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2947391657
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2947391657Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1152/jn.00104.2019Digital Object Identifier
- Title
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Oxygen-sensitive interneurons exhibit increased activity and GABA release during ROS scavenging in the cerebral cortex of the western painted turtleWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2019Year of publication
- Publication date
-
2019-05-29Full publication date if available
- Authors
-
Peter John Hawrysh, Leslie T. BuckList of authors in order
- Landing page
-
https://doi.org/10.1152/jn.00104.2019Publisher landing page
- PDF URL
-
https://journals.physiology.org/doi/pdf/10.1152/jn.00104.2019Direct link to full text PDF
- Open access
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YesWhether a free full text is available
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-
bronzeOpen access status per OpenAlex
- OA URL
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https://journals.physiology.org/doi/pdf/10.1152/jn.00104.2019Direct OA link when available
- Concepts
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Turtle (robot), Scavenging, Neuroscience, Cerebral cortex, Reactive oxygen species, Chemistry, Oxygen, Biology, Ecology, Biochemistry, Antioxidant, Organic chemistryTop concepts (fields/topics) attached by OpenAlex
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10Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2, 2024: 2, 2023: 1, 2022: 1, 2021: 3Per-year citation counts (last 5 years)
- References (count)
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61Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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