Oxygen-Vacancy Engineering of Cerium-Oxide Nanoparticles for Antioxidant Activity Article Swipe

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Cerium oxide Nanoparticle Antioxidant Nanomaterials Oxygen Cerium Reactive oxygen species Nanotoxicology Materials science Nanotechnology Oxide Chemistry Internalization Vacancy defect Chemical engineering Inorganic chemistry Biochemistry Metallurgy Organic chemistry Cell Engineering Crystallography

Cindy Gunawan , Megan S. Lord , Emma C. Lovell , Roong Jien Wong , Moon Sun Jung , Diana Oscar , Riti Mann , Rose Amal ·

YOU? · · 2019 · Open Access · · DOI: https://doi.org/10.1021/acsomega.9b00521 · OA: W2947460575

To address an important challenge in the engineering of antioxidant nanoparticles, the present work devised a surface-to-bulk migration of oxygen vacancies in the oxygen radical-scavenging cerium-oxide nanoparticles. The study highlights the significance of surface oxygen vacancies in the intended cellular internalization and, subsequently, the radical scavenging activity of the nanoparticles inside the cells. The findings advise future development of therapeutic antioxidant nanomaterials to also include engineering of the particles for enhanced surface defects not only for the accessibility of their oxygen vacancies but also, equally important, rendering them bioavailable for cellular uptake.