P04.01 Early recovery of radiation induced lymphopenia in NSCLC stage III lung cancer: correlation with prognosis in a prospective study Article Swipe
Thomas Höfer
,
A.E. Nieto
,
Lukas Kaesmann
,
CJ Pelikan
,
Julian Taugner
,
S. Mathur
,
Chukwuka Eze
,
Claus Belka
,
F Manappov
,
Elfriede Noeßner
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1136/jitc-2024-itoc10.36
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1136/jitc-2024-itoc10.36
Background To explore the impact of dynamic changes of leukocyte subsets during therapy on patient prognosis in inoperable stage III NSCLC, we compared in a prospective explorative single-center study the kinetics of major leukocyte subsets (absolute cell counts, ALC) before, during, and after definitive treatment and correlated it to survival to identify subpopulations associated with maximal patient benefit. Materials and Methods We analyzed peripheral blood of 20 patients with inoperable stage III NSCLC, either treated with radiation therapy (RT), concurrent chemo-radiotherapy (cCRT), or cCRT with additional concurrent (nivolumab) or sequential (durvalumab) immune-checkpoint inhibition therapy. Blood samples were collected at 9 time points including before treatment begin (baseline), at the end of therapy, and during 1 y follow-up after treatment. Analysis included multi-color flow cytometry. Statistical analysis was conducted for leukocyte subpopulations (T cells, B cells, NK cells, neutrophils, thrombocytes), IL-6, progression-free survival (PFS) and overall survival (OS). Results The increase of ALC after the end of thoracic radiotherapy (TRT) until 6 months thereafter was a predictor of PFS. Baseline lymphocyte counts showed no significant correlation to PFS or OS. Early recovery (within three months after TRT) of cell counts in lymphocytes, total CD3+ T cells, and CD8+ cytotoxic T cells were predictors of longer PFS. According to discriminant analysis, B cells, neutrophil-lymphocyte-ratio (NLR), CD4+ T helper cells, and NK cells contributed most to prolonged PFS. Conclusions Our explorative results suggest that early recovery of absolute lymphocyte counts (ALC) of CD8+ T-cells, CD4+ T cells, and NK-cells after (chemo-) radiation-based definitive therapy of inoperable stage III NSCLC is associated with increased PFS. Immune checkpoint therapy showed a trend towards favorable PFS, OS, and fewer local tumor recurrences. T. Hofer: None. A.E. Nieto: None. L. Kaesmann: B. Research Grant (principal investigator, collaborator or consultant and pending grants as well as grants already received); Modest; AstraZeneca. D. Speakers Bureau/Honoraria (speakers bureau, symposia, and expert witness); Modest; Amgen. C.J. Pelikan: None. J. Taugner: None. S. Mathur: None. C. Eze: None. C. Belka: B. Research Grant (principal investigator, collaborator or consultant and pending grants as well as grants already received); Modest; Brainlab, Elekta, ViewRay. D. Speakers Bureau/Honoraria (speakers bureau, symposia, and expert witness); Modest; ViewRay, Bristol Myers Squibb, Roche, Merck & Co, AstraZeneca. F. Consultant/Advisory Board; Modest; ViewRay, Bristol Myers Squibb, Roche, Merck & Co, AstraZeneca, European Society for Radiotherapy and Oncology. F. Manappov: B. Research Grant (principal investigator, collaborator or consultant and pending grants as well as grants already received); Modest; AstraZeneca. D. Speakers Bureau/Honoraria (speakers bureau, symposia, and expert witness); Modest; AstraZeneca, Novartis, Roche, Eli Lilly, Elekta, Brainlab. F. Consultant/Advisory Board; Modest; AstraZeneca, Novartis. E. Noessner: None.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1136/jitc-2024-itoc10.36
- https://jitc.bmj.com/content/jitc/12/Suppl_1/A20.1.full.pdf
- OA Status
- hybrid
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4392985060
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4392985060Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1136/jitc-2024-itoc10.36Digital Object Identifier
- Title
-
P04.01 Early recovery of radiation induced lymphopenia in NSCLC stage III lung cancer: correlation with prognosis in a prospective studyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-03-01Full publication date if available
- Authors
-
Thomas Höfer, A.E. Nieto, Lukas Kaesmann, CJ Pelikan, Julian Taugner, S. Mathur, Chukwuka Eze, Claus Belka, F Manappov, Elfriede NoeßnerList of authors in order
- Landing page
-
https://doi.org/10.1136/jitc-2024-itoc10.36Publisher landing page
- PDF URL
-
https://jitc.bmj.com/content/jitc/12/Suppl_1/A20.1.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://jitc.bmj.com/content/jitc/12/Suppl_1/A20.1.full.pdfDirect OA link when available
- Concepts
-
Medicine, Stage (stratigraphy), Lung cancer, Oncology, Radiation therapy, Cancer, Correlation, Internal medicine, Prospective cohort study, Biology, Mathematics, Geometry, PaleontologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4392985060 |
|---|---|
| doi | https://doi.org/10.1136/jitc-2024-itoc10.36 |
| ids.doi | https://doi.org/10.1136/jitc-2024-itoc10.36 |
| ids.openalex | https://openalex.org/W4392985060 |
| fwci | 0.0 |
| type | article |
| title | P04.01 Early recovery of radiation induced lymphopenia in NSCLC stage III lung cancer: correlation with prognosis in a prospective study |
| biblio.issue | |
| biblio.volume | |
| biblio.last_page | A20 |
| biblio.first_page | A20.1 |
| topics[0].id | https://openalex.org/T11355 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9638000130653381 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2730 |
| topics[0].subfield.display_name | Oncology |
| topics[0].display_name | Inflammatory Biomarkers in Disease Prognosis |
| topics[1].id | https://openalex.org/T10158 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9448999762535095 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2730 |
| topics[1].subfield.display_name | Oncology |
| topics[1].display_name | Cancer Immunotherapy and Biomarkers |
| topics[2].id | https://openalex.org/T10515 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.9377999901771545 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1306 |
| topics[2].subfield.display_name | Cancer Research |
| topics[2].display_name | Cancer-related molecular mechanisms research |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C71924100 |
| concepts[0].level | 0 |
| concepts[0].score | 0.7078222036361694 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[0].display_name | Medicine |
| concepts[1].id | https://openalex.org/C146357865 |
| concepts[1].level | 2 |
| concepts[1].score | 0.6682651042938232 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q1123245 |
| concepts[1].display_name | Stage (stratigraphy) |
| concepts[2].id | https://openalex.org/C2776256026 |
| concepts[2].level | 2 |
| concepts[2].score | 0.6541187763214111 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q47912 |
| concepts[2].display_name | Lung cancer |
| concepts[3].id | https://openalex.org/C143998085 |
| concepts[3].level | 1 |
| concepts[3].score | 0.6033280491828918 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q162555 |
| concepts[3].display_name | Oncology |
| concepts[4].id | https://openalex.org/C509974204 |
| concepts[4].level | 2 |
| concepts[4].score | 0.5137313604354858 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q180507 |
| concepts[4].display_name | Radiation therapy |
| concepts[5].id | https://openalex.org/C121608353 |
| concepts[5].level | 2 |
| concepts[5].score | 0.5053251385688782 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q12078 |
| concepts[5].display_name | Cancer |
| concepts[6].id | https://openalex.org/C117220453 |
| concepts[6].level | 2 |
| concepts[6].score | 0.5039889216423035 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q5172842 |
| concepts[6].display_name | Correlation |
| concepts[7].id | https://openalex.org/C126322002 |
| concepts[7].level | 1 |
| concepts[7].score | 0.4650622010231018 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[7].display_name | Internal medicine |
| concepts[8].id | https://openalex.org/C188816634 |
| concepts[8].level | 2 |
| concepts[8].score | 0.4276266396045685 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q2113324 |
| concepts[8].display_name | Prospective cohort study |
| concepts[9].id | https://openalex.org/C86803240 |
| concepts[9].level | 0 |
| concepts[9].score | 0.0743640661239624 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[9].display_name | Biology |
| concepts[10].id | https://openalex.org/C33923547 |
| concepts[10].level | 0 |
| concepts[10].score | 0.04782480001449585 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q395 |
| concepts[10].display_name | Mathematics |
| concepts[11].id | https://openalex.org/C2524010 |
| concepts[11].level | 1 |
| concepts[11].score | 0.0 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q8087 |
| concepts[11].display_name | Geometry |
| concepts[12].id | https://openalex.org/C151730666 |
| concepts[12].level | 1 |
| concepts[12].score | 0.0 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q7205 |
| concepts[12].display_name | Paleontology |
| keywords[0].id | https://openalex.org/keywords/medicine |
| keywords[0].score | 0.7078222036361694 |
| keywords[0].display_name | Medicine |
| keywords[1].id | https://openalex.org/keywords/stage |
| keywords[1].score | 0.6682651042938232 |
| keywords[1].display_name | Stage (stratigraphy) |
| keywords[2].id | https://openalex.org/keywords/lung-cancer |
| keywords[2].score | 0.6541187763214111 |
| keywords[2].display_name | Lung cancer |
| keywords[3].id | https://openalex.org/keywords/oncology |
| keywords[3].score | 0.6033280491828918 |
| keywords[3].display_name | Oncology |
| keywords[4].id | https://openalex.org/keywords/radiation-therapy |
| keywords[4].score | 0.5137313604354858 |
| keywords[4].display_name | Radiation therapy |
| keywords[5].id | https://openalex.org/keywords/cancer |
| keywords[5].score | 0.5053251385688782 |
| keywords[5].display_name | Cancer |
| keywords[6].id | https://openalex.org/keywords/correlation |
| keywords[6].score | 0.5039889216423035 |
| keywords[6].display_name | Correlation |
| keywords[7].id | https://openalex.org/keywords/internal-medicine |
| keywords[7].score | 0.4650622010231018 |
| keywords[7].display_name | Internal medicine |
| keywords[8].id | https://openalex.org/keywords/prospective-cohort-study |
| keywords[8].score | 0.4276266396045685 |
| keywords[8].display_name | Prospective cohort study |
| keywords[9].id | https://openalex.org/keywords/biology |
| keywords[9].score | 0.0743640661239624 |
| keywords[9].display_name | Biology |
| keywords[10].id | https://openalex.org/keywords/mathematics |
| keywords[10].score | 0.04782480001449585 |
| keywords[10].display_name | Mathematics |
| language | en |
| locations[0].id | doi:10.1136/jitc-2024-itoc10.36 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4363604354 |
| locations[0].source.issn | |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Poster presentations |
| locations[0].source.host_organization | |
| locations[0].source.host_organization_name | |
| locations[0].license | cc-by-nc |
| locations[0].pdf_url | https://jitc.bmj.com/content/jitc/12/Suppl_1/A20.1.full.pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | proceedings-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by-nc |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Poster Presentations |
| locations[0].landing_page_url | https://doi.org/10.1136/jitc-2024-itoc10.36 |
| locations[1].id | pmh:oai:doaj.org/article:92717d19dc3b47bfa5bfea588e6b15ea |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306401280 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[1].source.host_organization | |
| locations[1].source.host_organization_name | |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | submittedVersion |
| locations[1].raw_type | article |
| locations[1].license_id | |
| locations[1].is_accepted | False |
| locations[1].is_published | False |
| locations[1].raw_source_name | Journal for ImmunoTherapy of Cancer, Vol 12, Iss Suppl 1 (2024) |
| locations[1].landing_page_url | https://doaj.org/article/92717d19dc3b47bfa5bfea588e6b15ea |
| indexed_in | crossref, doaj |
| authorships[0].author.id | https://openalex.org/A5022095447 |
| authorships[0].author.orcid | https://orcid.org/0000-0003-3560-8780 |
| authorships[0].author.display_name | Thomas Höfer |
| authorships[0].countries | DE |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I3018134672 |
| authorships[0].affiliations[0].raw_affiliation_string | Helmholtz Zentrum München, IMA-TCI, München, Germany |
| authorships[0].institutions[0].id | https://openalex.org/I3018134672 |
| authorships[0].institutions[0].ror | https://ror.org/00cfam450 |
| authorships[0].institutions[0].type | facility |
| authorships[0].institutions[0].lineage | https://openalex.org/I1305996414, https://openalex.org/I3018134672 |
| authorships[0].institutions[0].country_code | DE |
| authorships[0].institutions[0].display_name | Helmholtz Zentrum München |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | T Hofer |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Helmholtz Zentrum München, IMA-TCI, München, Germany |
| authorships[1].author.id | https://openalex.org/A5113147582 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | A.E. Nieto |
| authorships[1].countries | DE |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I3018771216, https://openalex.org/I8204097 |
| authorships[1].affiliations[0].raw_affiliation_string | LMU University Hospital, Department of Radiation Oncology, München, Germany |
| authorships[1].institutions[0].id | https://openalex.org/I3018771216 |
| authorships[1].institutions[0].ror | https://ror.org/02jet3w32 |
| authorships[1].institutions[0].type | healthcare |
| authorships[1].institutions[0].lineage | https://openalex.org/I3018771216, https://openalex.org/I8204097 |
| authorships[1].institutions[0].country_code | DE |
| authorships[1].institutions[0].display_name | LMU Klinikum |
| authorships[1].institutions[1].id | https://openalex.org/I8204097 |
| authorships[1].institutions[1].ror | https://ror.org/05591te55 |
| authorships[1].institutions[1].type | education |
| authorships[1].institutions[1].lineage | https://openalex.org/I8204097 |
| authorships[1].institutions[1].country_code | DE |
| authorships[1].institutions[1].display_name | Ludwig-Maximilians-Universität München |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | AE Nieto |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | LMU University Hospital, Department of Radiation Oncology, München, Germany |
| authorships[2].author.id | https://openalex.org/A5107861908 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Lukas Kaesmann |
| authorships[2].countries | DE |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I3018771216, https://openalex.org/I8204097 |
| authorships[2].affiliations[0].raw_affiliation_string | LMU University Hospital, Department of Radiation Oncology, München, Germany |
| authorships[2].institutions[0].id | https://openalex.org/I3018771216 |
| authorships[2].institutions[0].ror | https://ror.org/02jet3w32 |
| authorships[2].institutions[0].type | healthcare |
| authorships[2].institutions[0].lineage | https://openalex.org/I3018771216, https://openalex.org/I8204097 |
| authorships[2].institutions[0].country_code | DE |
| authorships[2].institutions[0].display_name | LMU Klinikum |
| authorships[2].institutions[1].id | https://openalex.org/I8204097 |
| authorships[2].institutions[1].ror | https://ror.org/05591te55 |
| authorships[2].institutions[1].type | education |
| authorships[2].institutions[1].lineage | https://openalex.org/I8204097 |
| authorships[2].institutions[1].country_code | DE |
| authorships[2].institutions[1].display_name | Ludwig-Maximilians-Universität München |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | L Kaesmann |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | LMU University Hospital, Department of Radiation Oncology, München, Germany |
| authorships[3].author.id | https://openalex.org/A5114137874 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | CJ Pelikan |
| authorships[3].countries | DE |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I3018134672 |
| authorships[3].affiliations[0].raw_affiliation_string | Helmholtz Zentrum München, IMA-TCI, München, Germany |
| authorships[3].institutions[0].id | https://openalex.org/I3018134672 |
| authorships[3].institutions[0].ror | https://ror.org/00cfam450 |
| authorships[3].institutions[0].type | facility |
| authorships[3].institutions[0].lineage | https://openalex.org/I1305996414, https://openalex.org/I3018134672 |
| authorships[3].institutions[0].country_code | DE |
| authorships[3].institutions[0].display_name | Helmholtz Zentrum München |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | CJ Pelikan |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Helmholtz Zentrum München, IMA-TCI, München, Germany |
| authorships[4].author.id | https://openalex.org/A5072421835 |
| authorships[4].author.orcid | https://orcid.org/0000-0003-1473-1202 |
| authorships[4].author.display_name | Julian Taugner |
| authorships[4].countries | DE |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I3018771216, https://openalex.org/I8204097 |
| authorships[4].affiliations[0].raw_affiliation_string | LMU University Hospital, Department of Radiation Oncology, München, Germany |
| authorships[4].institutions[0].id | https://openalex.org/I3018771216 |
| authorships[4].institutions[0].ror | https://ror.org/02jet3w32 |
| authorships[4].institutions[0].type | healthcare |
| authorships[4].institutions[0].lineage | https://openalex.org/I3018771216, https://openalex.org/I8204097 |
| authorships[4].institutions[0].country_code | DE |
| authorships[4].institutions[0].display_name | LMU Klinikum |
| authorships[4].institutions[1].id | https://openalex.org/I8204097 |
| authorships[4].institutions[1].ror | https://ror.org/05591te55 |
| authorships[4].institutions[1].type | education |
| authorships[4].institutions[1].lineage | https://openalex.org/I8204097 |
| authorships[4].institutions[1].country_code | DE |
| authorships[4].institutions[1].display_name | Ludwig-Maximilians-Universität München |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | J Taugner |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | LMU University Hospital, Department of Radiation Oncology, München, Germany |
| authorships[5].author.id | https://openalex.org/A5108897472 |
| authorships[5].author.orcid | |
| authorships[5].author.display_name | S. Mathur |
| authorships[5].countries | DE |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I3018134672 |
| authorships[5].affiliations[0].raw_affiliation_string | Helmholtz Zentrum München, IMA-TCI, München, Germany |
| authorships[5].institutions[0].id | https://openalex.org/I3018134672 |
| authorships[5].institutions[0].ror | https://ror.org/00cfam450 |
| authorships[5].institutions[0].type | facility |
| authorships[5].institutions[0].lineage | https://openalex.org/I1305996414, https://openalex.org/I3018134672 |
| authorships[5].institutions[0].country_code | DE |
| authorships[5].institutions[0].display_name | Helmholtz Zentrum München |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | S Mathur |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Helmholtz Zentrum München, IMA-TCI, München, Germany |
| authorships[6].author.id | https://openalex.org/A5017268914 |
| authorships[6].author.orcid | https://orcid.org/0000-0003-3779-1398 |
| authorships[6].author.display_name | Chukwuka Eze |
| authorships[6].countries | DE |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I3018771216, https://openalex.org/I8204097 |
| authorships[6].affiliations[0].raw_affiliation_string | LMU University Hospital, Department of Radiation Oncology, München, Germany |
| authorships[6].institutions[0].id | https://openalex.org/I3018771216 |
| authorships[6].institutions[0].ror | https://ror.org/02jet3w32 |
| authorships[6].institutions[0].type | healthcare |
| authorships[6].institutions[0].lineage | https://openalex.org/I3018771216, https://openalex.org/I8204097 |
| authorships[6].institutions[0].country_code | DE |
| authorships[6].institutions[0].display_name | LMU Klinikum |
| authorships[6].institutions[1].id | https://openalex.org/I8204097 |
| authorships[6].institutions[1].ror | https://ror.org/05591te55 |
| authorships[6].institutions[1].type | education |
| authorships[6].institutions[1].lineage | https://openalex.org/I8204097 |
| authorships[6].institutions[1].country_code | DE |
| authorships[6].institutions[1].display_name | Ludwig-Maximilians-Universität München |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | C Eze |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | LMU University Hospital, Department of Radiation Oncology, München, Germany |
| authorships[7].author.id | https://openalex.org/A5038323479 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-1287-7825 |
| authorships[7].author.display_name | Claus Belka |
| authorships[7].countries | DE |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I3018771216, https://openalex.org/I8204097 |
| authorships[7].affiliations[0].raw_affiliation_string | LMU University Hospital, Department of Radiation Oncology, München, Germany |
| authorships[7].institutions[0].id | https://openalex.org/I3018771216 |
| authorships[7].institutions[0].ror | https://ror.org/02jet3w32 |
| authorships[7].institutions[0].type | healthcare |
| authorships[7].institutions[0].lineage | https://openalex.org/I3018771216, https://openalex.org/I8204097 |
| authorships[7].institutions[0].country_code | DE |
| authorships[7].institutions[0].display_name | LMU Klinikum |
| authorships[7].institutions[1].id | https://openalex.org/I8204097 |
| authorships[7].institutions[1].ror | https://ror.org/05591te55 |
| authorships[7].institutions[1].type | education |
| authorships[7].institutions[1].lineage | https://openalex.org/I8204097 |
| authorships[7].institutions[1].country_code | DE |
| authorships[7].institutions[1].display_name | Ludwig-Maximilians-Universität München |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | C Belka |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | LMU University Hospital, Department of Radiation Oncology, München, Germany |
| authorships[8].author.id | https://openalex.org/A5094199532 |
| authorships[8].author.orcid | |
| authorships[8].author.display_name | F Manappov |
| authorships[8].countries | DE |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I3018771216, https://openalex.org/I8204097 |
| authorships[8].affiliations[0].raw_affiliation_string | LMU University Hospital, Department of Radiation Oncology, München, Germany |
| authorships[8].institutions[0].id | https://openalex.org/I3018771216 |
| authorships[8].institutions[0].ror | https://ror.org/02jet3w32 |
| authorships[8].institutions[0].type | healthcare |
| authorships[8].institutions[0].lineage | https://openalex.org/I3018771216, https://openalex.org/I8204097 |
| authorships[8].institutions[0].country_code | DE |
| authorships[8].institutions[0].display_name | LMU Klinikum |
| authorships[8].institutions[1].id | https://openalex.org/I8204097 |
| authorships[8].institutions[1].ror | https://ror.org/05591te55 |
| authorships[8].institutions[1].type | education |
| authorships[8].institutions[1].lineage | https://openalex.org/I8204097 |
| authorships[8].institutions[1].country_code | DE |
| authorships[8].institutions[1].display_name | Ludwig-Maximilians-Universität München |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | F Manappov |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | LMU University Hospital, Department of Radiation Oncology, München, Germany |
| authorships[9].author.id | https://openalex.org/A5080949843 |
| authorships[9].author.orcid | https://orcid.org/0000-0003-4709-9266 |
| authorships[9].author.display_name | Elfriede Noeßner |
| authorships[9].countries | DE |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I3018134672 |
| authorships[9].affiliations[0].raw_affiliation_string | Helmholtz Zentrum München, IMA-TCI, München, Germany |
| authorships[9].institutions[0].id | https://openalex.org/I3018134672 |
| authorships[9].institutions[0].ror | https://ror.org/00cfam450 |
| authorships[9].institutions[0].type | facility |
| authorships[9].institutions[0].lineage | https://openalex.org/I1305996414, https://openalex.org/I3018134672 |
| authorships[9].institutions[0].country_code | DE |
| authorships[9].institutions[0].display_name | Helmholtz Zentrum München |
| authorships[9].author_position | last |
| authorships[9].raw_author_name | E Noessner |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Helmholtz Zentrum München, IMA-TCI, München, Germany |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://jitc.bmj.com/content/jitc/12/Suppl_1/A20.1.full.pdf |
| open_access.oa_status | hybrid |
| open_access.any_repository_has_fulltext | False |
| created_date | 2024-03-21T00:00:00 |
| display_name | P04.01 Early recovery of radiation induced lymphopenia in NSCLC stage III lung cancer: correlation with prognosis in a prospective study |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11355 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9638000130653381 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2730 |
| primary_topic.subfield.display_name | Oncology |
| primary_topic.display_name | Inflammatory Biomarkers in Disease Prognosis |
| related_works | https://openalex.org/W2503350049, https://openalex.org/W2329386257, https://openalex.org/W2397616145, https://openalex.org/W2355955825, https://openalex.org/W2056534599, https://openalex.org/W2397320258, https://openalex.org/W4206801305, https://openalex.org/W2064573700, https://openalex.org/W4324058133, https://openalex.org/W2382476776 |
| cited_by_count | 0 |
| locations_count | 2 |
| best_oa_location.id | doi:10.1136/jitc-2024-itoc10.36 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4363604354 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Poster presentations |
| best_oa_location.source.host_organization | |
| best_oa_location.source.host_organization_name | |
| best_oa_location.license | cc-by-nc |
| best_oa_location.pdf_url | https://jitc.bmj.com/content/jitc/12/Suppl_1/A20.1.full.pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | proceedings-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by-nc |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Poster Presentations |
| best_oa_location.landing_page_url | https://doi.org/10.1136/jitc-2024-itoc10.36 |
| primary_location.id | doi:10.1136/jitc-2024-itoc10.36 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4363604354 |
| primary_location.source.issn | |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Poster presentations |
| primary_location.source.host_organization | |
| primary_location.source.host_organization_name | |
| primary_location.license | cc-by-nc |
| primary_location.pdf_url | https://jitc.bmj.com/content/jitc/12/Suppl_1/A20.1.full.pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | proceedings-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by-nc |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Poster Presentations |
| primary_location.landing_page_url | https://doi.org/10.1136/jitc-2024-itoc10.36 |
| publication_date | 2024-03-01 |
| publication_year | 2024 |
| referenced_works_count | 0 |
| abstract_inverted_index.1 | 114 |
| abstract_inverted_index.6 | 160 |
| abstract_inverted_index.9 | 99 |
| abstract_inverted_index.B | 133, 209 |
| abstract_inverted_index.T | 193, 198, 214, 242 |
| abstract_inverted_index.a | 24, 164, 265 |
| abstract_inverted_index.y | 115 |
| abstract_inverted_index.(T | 131 |
| abstract_inverted_index.20 | 66 |
| abstract_inverted_index.B. | 284, 328, 389 |
| abstract_inverted_index.D. | 303, 349, 408 |
| abstract_inverted_index.F. | 368, 425 |
| abstract_inverted_index.NK | 135, 218 |
| abstract_inverted_index.To | 1 |
| abstract_inverted_index.We | 61 |
| abstract_inverted_index.as | 295, 297, 339, 341, 400, 402 |
| abstract_inverted_index.at | 98, 107 |
| abstract_inverted_index.in | 16, 23, 189 |
| abstract_inverted_index.is | 256 |
| abstract_inverted_index.it | 47 |
| abstract_inverted_index.no | 172 |
| abstract_inverted_index.of | 5, 8, 31, 65, 110, 150, 155, 166, 186, 202, 233, 238, 251 |
| abstract_inverted_index.on | 13 |
| abstract_inverted_index.or | 82, 88, 177, 290, 334, 395 |
| abstract_inverted_index.to | 48, 50, 175, 206, 222 |
| abstract_inverted_index.we | 21 |
| abstract_inverted_index.ALC | 151 |
| abstract_inverted_index.Co, | 366, 379 |
| abstract_inverted_index.Eli | 421 |
| abstract_inverted_index.III | 19, 71, 254 |
| abstract_inverted_index.OS, | 270 |
| abstract_inverted_index.OS. | 178 |
| abstract_inverted_index.Our | 226 |
| abstract_inverted_index.PFS | 176 |
| abstract_inverted_index.The | 148 |
| abstract_inverted_index.and | 41, 45, 59, 112, 143, 195, 217, 244, 271, 292, 309, 336, 355, 385, 397, 414 |
| abstract_inverted_index.end | 109, 154 |
| abstract_inverted_index.for | 128, 383 |
| abstract_inverted_index.the | 3, 29, 108, 153 |
| abstract_inverted_index.was | 126, 163 |
| abstract_inverted_index.ALC) | 38 |
| abstract_inverted_index.CD3+ | 192 |
| abstract_inverted_index.CD4+ | 213, 241 |
| abstract_inverted_index.CD8+ | 196, 239 |
| abstract_inverted_index.PFS, | 269 |
| abstract_inverted_index.PFS. | 167, 204, 224, 260 |
| abstract_inverted_index.TRT) | 185 |
| abstract_inverted_index.cCRT | 83 |
| abstract_inverted_index.cell | 36, 187 |
| abstract_inverted_index.flow | 122 |
| abstract_inverted_index.most | 221 |
| abstract_inverted_index.that | 230 |
| abstract_inverted_index.time | 100 |
| abstract_inverted_index.well | 296, 340, 401 |
| abstract_inverted_index.were | 96, 200 |
| abstract_inverted_index.with | 54, 68, 75, 84, 258 |
| abstract_inverted_index.& | 365, 378 |
| abstract_inverted_index.(ALC) | 237 |
| abstract_inverted_index.(OS). | 146 |
| abstract_inverted_index.(PFS) | 142 |
| abstract_inverted_index.(RT), | 78 |
| abstract_inverted_index.(TRT) | 158 |
| abstract_inverted_index.<b>C. | 323, 326 |
| abstract_inverted_index.<b>E. | 431 |
| abstract_inverted_index.<b>F. | 387 |
| abstract_inverted_index.<b>J. | 317 |
| abstract_inverted_index.<b>L. | 282 |
| abstract_inverted_index.<b>S. | 320 |
| abstract_inverted_index.<b>T. | 276 |
| abstract_inverted_index.Blood | 94 |
| abstract_inverted_index.Early | 179 |
| abstract_inverted_index.Grant | 286, 330, 391 |
| abstract_inverted_index.IL-6, | 139 |
| abstract_inverted_index.Merck | 364, 377 |
| abstract_inverted_index.Myers | 361, 374 |
| abstract_inverted_index.NSCLC | 255 |
| abstract_inverted_index.None. | 278, 281, 316, 319, 322, 325, 433 |
| abstract_inverted_index.after | 42, 117, 152, 184, 246 |
| abstract_inverted_index.begin | 105 |
| abstract_inverted_index.blood | 64 |
| abstract_inverted_index.cells | 199, 219 |
| abstract_inverted_index.early | 231 |
| abstract_inverted_index.fewer | 272 |
| abstract_inverted_index.local | 273 |
| abstract_inverted_index.major | 32 |
| abstract_inverted_index.stage | 18, 70, 253 |
| abstract_inverted_index.study | 28 |
| abstract_inverted_index.three | 182 |
| abstract_inverted_index.total | 191 |
| abstract_inverted_index.trend | 266 |
| abstract_inverted_index.tumor | 274 |
| abstract_inverted_index.until | 159 |
| abstract_inverted_index.(NLR), | 212 |
| abstract_inverted_index.Amgen. | 313 |
| abstract_inverted_index.Board; | 370, 427 |
| abstract_inverted_index.Immune | 261 |
| abstract_inverted_index.Lilly, | 422 |
| abstract_inverted_index.NSCLC, | 20, 72 |
| abstract_inverted_index.Roche, | 363, 376, 420 |
| abstract_inverted_index.before | 103 |
| abstract_inverted_index.cells, | 132, 134, 136, 194, 210, 216, 243 |
| abstract_inverted_index.counts | 170, 188, 236 |
| abstract_inverted_index.during | 11, 113 |
| abstract_inverted_index.either | 73 |
| abstract_inverted_index.expert | 310, 356, 415 |
| abstract_inverted_index.grants | 294, 298, 338, 342, 399, 403 |
| abstract_inverted_index.helper | 215 |
| abstract_inverted_index.impact | 4 |
| abstract_inverted_index.longer | 203 |
| abstract_inverted_index.months | 161, 183 |
| abstract_inverted_index.points | 101 |
| abstract_inverted_index.showed | 171, 264 |
| abstract_inverted_index.(cCRT), | 81 |
| abstract_inverted_index.(within | 181 |
| abstract_inverted_index.<b>A.E. | 279 |
| abstract_inverted_index.<b>C.J. | 314 |
| abstract_inverted_index.Bristol | 360, 373 |
| abstract_inverted_index.Elekta, | 347, 423 |
| abstract_inverted_index.Modest; | 301, 312, 345, 358, 371, 406, 417, 428 |
| abstract_inverted_index.Society | 382 |
| abstract_inverted_index.Squibb, | 362, 375 |
| abstract_inverted_index.already | 299, 343, 404 |
| abstract_inverted_index.before, | 39 |
| abstract_inverted_index.bureau, | 307, 353, 412 |
| abstract_inverted_index.changes | 7 |
| abstract_inverted_index.counts, | 37 |
| abstract_inverted_index.during, | 40 |
| abstract_inverted_index.dynamic | 6 |
| abstract_inverted_index.explore | 2 |
| abstract_inverted_index.maximal | 55 |
| abstract_inverted_index.overall | 144 |
| abstract_inverted_index.patient | 14, 56 |
| abstract_inverted_index.pending | 293, 337, 398 |
| abstract_inverted_index.results | 228 |
| abstract_inverted_index.samples | 95 |
| abstract_inverted_index.subsets | 10, 34 |
| abstract_inverted_index.suggest | 229 |
| abstract_inverted_index.therapy | 12, 77, 250, 263 |
| abstract_inverted_index.towards | 267 |
| abstract_inverted_index.treated | 74 |
| abstract_inverted_index.(chemo-) | 247 |
| abstract_inverted_index.Analysis | 119 |
| abstract_inverted_index.Baseline | 168 |
| abstract_inverted_index.European | 381 |
| abstract_inverted_index.Eze:</b> | 324 |
| abstract_inverted_index.NK-cells | 245 |
| abstract_inverted_index.Research | 285, 329, 390 |
| abstract_inverted_index.Speakers | 304, 350, 409 |
| abstract_inverted_index.T-cells, | 240 |
| abstract_inverted_index.ViewRay, | 359, 372 |
| abstract_inverted_index.ViewRay. | 348 |
| abstract_inverted_index.absolute | 234 |
| abstract_inverted_index.analysis | 125 |
| abstract_inverted_index.analyzed | 62 |
| abstract_inverted_index.benefit. | 57 |
| abstract_inverted_index.compared | 22 |
| abstract_inverted_index.identify | 51 |
| abstract_inverted_index.included | 120 |
| abstract_inverted_index.increase | 149 |
| abstract_inverted_index.kinetics | 30 |
| abstract_inverted_index.patients | 67 |
| abstract_inverted_index.recovery | 180, 232 |
| abstract_inverted_index.survival | 49, 141, 145 |
| abstract_inverted_index.therapy, | 111 |
| abstract_inverted_index.therapy. | 93 |
| abstract_inverted_index.thoracic | 156 |
| abstract_inverted_index.(absolute | 35 |
| abstract_inverted_index.(speakers | 306, 352, 411 |
| abstract_inverted_index.According | 205 |
| abstract_inverted_index.Brainlab, | 346 |
| abstract_inverted_index.Brainlab. | 424 |
| abstract_inverted_index.Novartis, | 419 |
| abstract_inverted_index.Novartis. | 430 |
| abstract_inverted_index.Oncology. | 386 |
| abstract_inverted_index.analysis, | 208 |
| abstract_inverted_index.collected | 97 |
| abstract_inverted_index.conducted | 127 |
| abstract_inverted_index.cytotoxic | 197 |
| abstract_inverted_index.favorable | 268 |
| abstract_inverted_index.follow-up | 116 |
| abstract_inverted_index.including | 102 |
| abstract_inverted_index.increased | 259 |
| abstract_inverted_index.leukocyte | 9, 33, 129 |
| abstract_inverted_index.predictor | 165 |
| abstract_inverted_index.prognosis | 15 |
| abstract_inverted_index.prolonged | 223 |
| abstract_inverted_index.radiation | 76 |
| abstract_inverted_index.symposia, | 308, 354, 413 |
| abstract_inverted_index.treatment | 44, 104 |
| abstract_inverted_index.witness); | 311, 357, 416 |
| abstract_inverted_index.(principal | 287, 331, 392 |
| abstract_inverted_index.Belka:</b> | 327 |
| abstract_inverted_index.Hofer:</b> | 277 |
| abstract_inverted_index.Nieto:</b> | 280 |
| abstract_inverted_index.additional | 85 |
| abstract_inverted_index.associated | 53, 257 |
| abstract_inverted_index.checkpoint | 262 |
| abstract_inverted_index.concurrent | 79, 86 |
| abstract_inverted_index.consultant | 291, 335, 396 |
| abstract_inverted_index.correlated | 46 |
| abstract_inverted_index.cytometry. | 123 |
| abstract_inverted_index.definitive | 43, 249 |
| abstract_inverted_index.inhibition | 92 |
| abstract_inverted_index.inoperable | 17, 69, 252 |
| abstract_inverted_index.lymphocyte | 169, 235 |
| abstract_inverted_index.peripheral | 63 |
| abstract_inverted_index.predictors | 201 |
| abstract_inverted_index.received); | 300, 344, 405 |
| abstract_inverted_index.sequential | 89 |
| abstract_inverted_index.thereafter | 162 |
| abstract_inverted_index.treatment. | 118 |
| abstract_inverted_index.(baseline), | 106 |
| abstract_inverted_index.(nivolumab) | 87 |
| abstract_inverted_index.Mathur:</b> | 321 |
| abstract_inverted_index.Statistical | 124 |
| abstract_inverted_index.contributed | 220 |
| abstract_inverted_index.correlation | 174 |
| abstract_inverted_index.explorative | 26, 227 |
| abstract_inverted_index.multi-color | 121 |
| abstract_inverted_index.prospective | 25 |
| abstract_inverted_index.significant | 173 |
| abstract_inverted_index.(durvalumab) | 90 |
| abstract_inverted_index.AstraZeneca, | 380, 418, 429 |
| abstract_inverted_index.AstraZeneca. | 302, 367, 407 |
| abstract_inverted_index.Methods</h3> | 60 |
| abstract_inverted_index.Pelikan:</b> | 315 |
| abstract_inverted_index.Radiotherapy | 384 |
| abstract_inverted_index.Taugner:</b> | 318 |
| abstract_inverted_index.collaborator | 289, 333, 394 |
| abstract_inverted_index.discriminant | 207 |
| abstract_inverted_index.lymphocytes, | 190 |
| abstract_inverted_index.neutrophils, | 137 |
| abstract_inverted_index.radiotherapy | 157 |
| abstract_inverted_index.recurrences. | 275 |
| abstract_inverted_index.<h3>Materials | 58 |
| abstract_inverted_index.Kaesmann:</b> | 283 |
| abstract_inverted_index.Manappov:</b> | 388 |
| abstract_inverted_index.Noessner:</b> | 432 |
| abstract_inverted_index.investigator, | 288, 332, 393 |
| abstract_inverted_index.single-center | 27 |
| abstract_inverted_index.subpopulations | 52, 130 |
| abstract_inverted_index.thrombocytes), | 138 |
| abstract_inverted_index.radiation-based | 248 |
| abstract_inverted_index.<h3>Results</h3> | 147 |
| abstract_inverted_index.Bureau/Honoraria | 305, 351, 410 |
| abstract_inverted_index.progression-free | 140 |
| abstract_inverted_index.immune-checkpoint | 91 |
| abstract_inverted_index.chemo-radiotherapy | 80 |
| abstract_inverted_index.<h3>Background</h3> | 0 |
| abstract_inverted_index.Consultant/Advisory | 369, 426 |
| abstract_inverted_index.<h3>Conclusions</h3> | 225 |
| abstract_inverted_index.neutrophil-lymphocyte-ratio | 211 |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 10 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7300000190734863 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.06567756 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |