P11.09.A SIGNIFICANCE OF MOLECULAR DIAGNOSTICS FOR THERAPEUTIC DECISION MAKING IN RECURRENT GLIOMA Article Swipe
Jens Blobner
,
Laura Dengler
,
Sven Blobner
,
Claudia Eberle
,
J Weller
,
Nico Teske
,
Philipp Karschnia
,
Katharina Rühlmann
,
Kathrin Heinrich
,
Frank Ziemann
,
Philipp A. Greif
,
Irmela Jeremias
,
Rachel Wuerstlein
,
Korbinian Hasselmann
,
Mario M. Dorostkar
,
Patrick N. Harter
,
Stefanie Quach
,
Veit M. Stoecklein
,
Nathalie L. Albert
,
Maximilian Niyazi
,
J. C. Tonn
,
Niklas Thon
,
C. Benedikt Westphalen
,
L Baumgarten
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1093/neuonc/noad137.243
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1093/neuonc/noad137.243
BACKGROUND Targeted therapies have substantially improved survival in cancer patients with malignancies outside the brain. Whether in-depth analysis for molecular alterations may also offer therapeutic avenues in primary brain tumors remains unclear. We herein present our institutional experience for glioma patients discussed in our interdisciplinary Molecular Tumor Board (MTB) implemented at the Comprehensive Cancer Center Munich (LMU). MATERIAL AND METHODS We retrospectively searched the database of the MTB for all recurrent glioma patients after previous therapy. Recommendations were based uponnext-generation sequencing results of individual patient’s tumor tissue. Clinical and molecular information, previous therapy regimens and outcome parameters were collected. RESULTS Overall, 73 consecutive recurrent glioma patients were identified. In the median, advanced molecular testing was initiated with the third tumor recurrence. The median turnaround time between initiation of molecular profiling and MTB case discussion was 48 ± 75 days (range: 32 - 536 days). Targetable mutations were found for 50 recurrent glioma patients (68.5%). IDH1 mutation (27/73; 37%), EGFR amplification (19/73; 26%) and NF1 mutation (8/73; 11%) were the most detected alterations and a molecular-based treatment recommendation could be made for all of them. Therapeutic recommendations were implemented in 12 cases (24%) and one third of these heavily pretreated patients experienced clinical benefit with at least partial response or disease stabilization. CONCLUSION In-depth molecular analysis of tumor tissue may guide targeted therapy also in brain tumor patients and considerable anti-tumor effects might be observed in selected cases. However, future studies to corroborate our results are needed.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/neuonc/noad137.243
- OA Status
- green
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4386537583
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4386537583Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1093/neuonc/noad137.243Digital Object Identifier
- Title
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P11.09.A SIGNIFICANCE OF MOLECULAR DIAGNOSTICS FOR THERAPEUTIC DECISION MAKING IN RECURRENT GLIOMAWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
-
2023-09-01Full publication date if available
- Authors
-
Jens Blobner, Laura Dengler, Sven Blobner, Claudia Eberle, J Weller, Nico Teske, Philipp Karschnia, Katharina Rühlmann, Kathrin Heinrich, Frank Ziemann, Philipp A. Greif, Irmela Jeremias, Rachel Wuerstlein, Korbinian Hasselmann, Mario M. Dorostkar, Patrick N. Harter, Stefanie Quach, Veit M. Stoecklein, Nathalie L. Albert, Maximilian Niyazi, J. C. Tonn, Niklas Thon, C. Benedikt Westphalen, L BaumgartenList of authors in order
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https://doi.org/10.1093/neuonc/noad137.243Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
- OA URL
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https://pmc.ncbi.nlm.nih.gov/articles/PMC10489158/pdf/noad137.243.pdfDirect OA link when available
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Medicine, Glioma, Internal medicine, Oncology, Brain tumor, IDH1, Disease, Targeted therapy, Cancer, Pathology, Mutation, Cancer research, Gene, Biology, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- Related works (count)
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10Other works algorithmically related by OpenAlex
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