P18 PROGNOSTIC IMPACT OF MITRAL REGURGITATION BEFORE AND AFTER TRANSCATHETER AORTIC VALVE REPLACEMENT IN PATIENTS WITH SEVERE LOW FLOW, LOW GRADIENT AORTIC STENOSIS Article Swipe
G Ferruzzi
,
Angelo Silverio
,
Michele Cimmino
,
Nadia Corcione
,
Michele Bellino
,
Tiziana Attisano
,
Cesare Baldi
,
Angela Morello
,
Giuseppe Biondi‐Zoccai
,
Rodolfo Citro
,
Carmine Vecchione
,
Gennaro Galasso
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1093/eurheartjsupp/suad111.105
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1093/eurheartjsupp/suad111.105
Background There is little evidence about the prognostic role of mitral regurgitation (MR) in patients with low flow, low gradient aortic stenosis (LFLG–AS) undergoing transcatheter aortic valve replacement (TAVR). Aims: The aim of this study was to assess the prevalence and outcome implication of moderately severe to severe MR in patients with LFLG–AS before and after TAVR. Methods This study included consecutive patients with LFLG–AS undergoing TAVR at two Italian high–volume centres. The study population was categorized according to the baseline MR severity and to the presence of MR improvement at discharge. The primary outcome was the composite of all–cause death and hospitalization for worsening heart failure (HF) up to one year. The secondary outcomes were the single components of the primary outcome. Results The study included 268 patients; 57 (21%) patients showed MR>2+. Patients with MR>2+ showed a lower one–year survival free from the primary outcome (Log–Rank <0.001; Figure1), all–cause death (Log–Rank <0.001), and HF hospitalization (Log–Rank <0.001) compared to patients with MR≤2+. At multivariable analysis, baseline MR>2+ was an independent predictor of the primary outcome (p<0.001). Among patients with baseline MR>2+, MR improvement was reported in 24 (44%) cases after TAVR. The one–year survival free from the primary outcome was significantly higher in patients with MR improvement than in those without (Log–Rank = 0.009), and both groups had a significantly lower survival free from the primary outcome when compared with patients with baseline MR <2+ (Figure 2). One–year survival free from the all–cause death (Log–Rank = 0.036) and HF hospitalization (Log–Rank = 0.005) was consistently higher in patients with MR improvement than in those without. Conclusions In this study, the presence of moderately severe to severe MR in LFLG–AS patients undergoing TAVR portend a worse clinical outcome at one year. TAVR may improve MR severity in nearly half of the patients, resulting in a potential outcome benefit after discharge.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/eurheartjsupp/suad111.105
- https://academic.oup.com/eurheartjsupp/article-pdf/25/Supplement_D/D45/50379215/suad111.105.pdf
- OA Status
- bronze
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4377019827
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- OpenAlex ID
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https://openalex.org/W4377019827Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1093/eurheartjsupp/suad111.105Digital Object Identifier
- Title
-
P18 PROGNOSTIC IMPACT OF MITRAL REGURGITATION BEFORE AND AFTER TRANSCATHETER AORTIC VALVE REPLACEMENT IN PATIENTS WITH SEVERE LOW FLOW, LOW GRADIENT AORTIC STENOSISWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-05-01Full publication date if available
- Authors
-
G Ferruzzi, Angelo Silverio, Michele Cimmino, Nadia Corcione, Michele Bellino, Tiziana Attisano, Cesare Baldi, Angela Morello, Giuseppe Biondi‐Zoccai, Rodolfo Citro, Carmine Vecchione, Gennaro GalassoList of authors in order
- Landing page
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https://doi.org/10.1093/eurheartjsupp/suad111.105Publisher landing page
- PDF URL
-
https://academic.oup.com/eurheartjsupp/article-pdf/25/Supplement_D/D45/50379215/suad111.105.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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bronzeOpen access status per OpenAlex
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https://academic.oup.com/eurheartjsupp/article-pdf/25/Supplement_D/D45/50379215/suad111.105.pdfDirect OA link when available
- Concepts
-
Medicine, Valve replacement, Cardiology, Internal medicine, Mitral regurgitation, Stenosis, Aortic valve replacement, Heart failure, Aortic valve stenosis, Population, Surgery, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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