p63 and ZNF148 cooperate to regulate head and neck squamous cell carcinoma Article Swipe
Rosalba Pecorari
,
Mara Mancini
,
Artem Smirnov
,
Giacomo Corleone
,
Flavia Novelli
,
Anna Maria Lena
,
Mariacristina Franzese Canonico
,
Manuela Montanaro
,
Angela Cappello
,
Andrea Sacconi
,
Gabriella Misso
,
Michela Falco
,
Chiara Tammaro
,
Fabiola Ciccosanti
,
Mauro Piacentini
,
Manuel Scimeca
,
Michele Caraglia
,
Giovanni Blandino
,
Alessandro Mauriello
,
Maurizio Fanciulli
,
Gerry Melino
,
Eleonora Candi
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1073/pnas.2500579122
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1073/pnas.2500579122
Head and neck squamous cell carcinoma (HNSCC) is a common and aggressive malignancy. While significant advances have been made in the management of low-grade cancer, treatment of advanced HNSCC remains challenging. Here, we used a proteomic approach to find binding partners of the oncogene p63, the most frequently amplified transcription factor in HNSCC. We identified a zinc finger protein, ZNF148, which is coexpressed and physically binds p63 in carcinoma cells. Genome occupancy analyses identified a functional transcribed enhancer-derived RNA (eRNA) upstream of the CCND1 gene occupied by both factors. Mechanistically, p63 and ZNF148 control transcription of this eRNA, leading to overexpression of cyclin D1 to reinforce tumor cell proliferation. Importantly, this axis is specific for cancer cells and remains inactive in normal epithelial cells. The expression levels of these factors and the eRNA are positively correlated in cancer and associated with advanced stage and metastasis. Collectively, our data reveal a molecular pathway controlling HNSCC progression and identify potential selective targets for cancer treatment.
Related Topics
Concepts
Oncogene
Head and neck squamous-cell carcinoma
Cancer research
Transcription factor
Cyclin D1
Cancer
Malignancy
Zinc finger
Biology
Enhancer
Cell
Metastasis
Cell cycle
Medicine
Head and neck cancer
Gene
Oncology
Internal medicine
Genetics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1073/pnas.2500579122
- https://www.pnas.org/doi/pdf/10.1073/pnas.2500579122
- OA Status
- hybrid
- Cited By
- 1
- References
- 60
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4412073613
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4412073613Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1073/pnas.2500579122Digital Object Identifier
- Title
-
p63 and ZNF148 cooperate to regulate head and neck squamous cell carcinomaWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-07-07Full publication date if available
- Authors
-
Rosalba Pecorari, Mara Mancini, Artem Smirnov, Giacomo Corleone, Flavia Novelli, Anna Maria Lena, Mariacristina Franzese Canonico, Manuela Montanaro, Angela Cappello, Andrea Sacconi, Gabriella Misso, Michela Falco, Chiara Tammaro, Fabiola Ciccosanti, Mauro Piacentini, Manuel Scimeca, Michele Caraglia, Giovanni Blandino, Alessandro Mauriello, Maurizio Fanciulli, Gerry Melino, Eleonora CandiList of authors in order
- Landing page
-
https://doi.org/10.1073/pnas.2500579122Publisher landing page
- PDF URL
-
https://www.pnas.org/doi/pdf/10.1073/pnas.2500579122Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://www.pnas.org/doi/pdf/10.1073/pnas.2500579122Direct OA link when available
- Concepts
-
Oncogene, Head and neck squamous-cell carcinoma, Cancer research, Transcription factor, Cyclin D1, Cancer, Malignancy, Zinc finger, Biology, Enhancer, Cell, Metastasis, Cell cycle, Medicine, Head and neck cancer, Gene, Oncology, Internal medicine, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1Per-year citation counts (last 5 years)
- References (count)
-
60Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| corresponding_author_ids | https://openalex.org/A5069317012, https://openalex.org/A5074304448, https://openalex.org/A5058280996, https://openalex.org/A5090027680 |
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| corresponding_institution_ids | https://openalex.org/I116067653, https://openalex.org/I4210116004, https://openalex.org/I4210153126 |
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| sustainable_development_goals[0].display_name | Good health and well-being |
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