Pancreatic senescence and its clinical manifestations Article Swipe

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Endocrine system Senescence Pancreas Pancreatic function Diabetes mellitus Enteroendocrine cell Exocrine pancreas Medicine Digestion (alchemy) Function (biology) Internal medicine Endocrinology Physiology Biology Hormone Chemistry Cell biology Chromatography

Lu Wang , Songbai Zheng ·

YOU? · · 2020 · Open Access · · DOI: https://doi.org/10.1002/agm2.12095 · OA: W3000587230

The pancreas is a vital organ which has both endocrine and exocrine functions and plays an essential role in food digestion and glucose metabolism. Pancreatic structure and function undergo a series of changes with aging and senescence. Pancreatic exocrine and endocrine function gradually change, which may lead to conditions such as dyspepsia and diabetes mellitus. Hence, clinicians need to be familiar with the characteristics of pancreatic senescence. This article reviews the manifestations of pancreatic senescence and its significance for clinical practice.