Parabens preferentially accumulate in metastatic breast tumors compared to benign breast tumors and the association of breast cancer risk factors with paraben accumulation Article Swipe
Craig A. Downs
,
Mohammad Mehdi Amin
,
Maryam Tabatabaeian
,
Afsane Chavoshani
,
Elham Amjadi
,
Alireza Afshari-Safavi
,
Roya Kelishadi
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1016/j.envadv.2022.100325
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1016/j.envadv.2022.100325
Parabens are a category of antimicrobial preservatives that may play a role in the etiology and epidemiology of cancers. Parabens are employed in a wide range of pharmaceuticals, cosmetics, personal care products, and processed foods. Parabens are thought to influence the evolution of carcinogenesis in breast cancer by acting as genotoxicants, cell proliferation factors, migratory and metastatic activators, and hyper-accumulate in breast cancer cells. A goal of this study was to characterize the relationship between paraben contamination and the incidence of both malignant and benign breast tumors in patients attending Hojati and Khanavadeh hospitals, in the city of Isfahan, Iran. A second goal was to examine the relationship among methyl, ethyl, n-propyl, and n-butyl paraben concentrations, exposure factors for parabens, and risk factors for breast cancer among patients with cancerous and non-cancerous breast tissues. A reference for median concentration of total parabens in healthy, non-tumor tissue is 160 ng/g (Barr et al., 2012). In this study, benign breast tumors had a mean concentration of 357 ng/g of total parabens. In contrast, malignant breast tissue had a mean concentration of 472 ng/g(mean) total parabens. Malignant tumors had higher n-propyl paraben (β=39.52; p=0.039) and n-butyl paraben (β=43.92; p=0.028) concentrations among the patients with a positive human epidermal growth factor receptor2 (HER2) rather than the patients with a negative HER2. Results indicated that higher age was associated with higher n-butyl paraben concentration (β=1.97; p=0.012) among the patients with malignant tumors. Moreover, the body mass index (BMI) had a positive relationship with ethyl paraben concentration (β=6.37; p= 0.030) among patients with malignant tumors. The questionnaire-survey used in this study was unable to discern why there was higher accumulation of parabens in the tumor-tissue types. Larger population-based longitudinal studies are necessary to confirm this association and to evaluate the association of parabens with clinical indicators of breast cancer and mortality.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.envadv.2022.100325
- OA Status
- gold
- Cited By
- 14
- References
- 156
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4310137355
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4310137355Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.envadv.2022.100325Digital Object Identifier
- Title
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Parabens preferentially accumulate in metastatic breast tumors compared to benign breast tumors and the association of breast cancer risk factors with paraben accumulationWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-11-28Full publication date if available
- Authors
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Craig A. Downs, Mohammad Mehdi Amin, Maryam Tabatabaeian, Afsane Chavoshani, Elham Amjadi, Alireza Afshari-Safavi, Roya KelishadiList of authors in order
- Landing page
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https://doi.org/10.1016/j.envadv.2022.100325Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1016/j.envadv.2022.100325Direct OA link when available
- Concepts
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Paraben, Breast cancer, Medicine, Internal medicine, Cancer, Oncology, Preservative, Gynecology, Physiology, Chemistry, Food scienceTop concepts (fields/topics) attached by OpenAlex
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14Total citation count in OpenAlex
- Citations by year (recent)
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2024: 8, 2023: 6Per-year citation counts (last 5 years)
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156Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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