Paraneoplastic Cerebellar Degeneration With P/Q-VGCC vs Yo Autoantibodies Article Swipe

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Pathology Autoantibody Purkinje cell Cerebellar cortex Cerebellum Biology Medicine Antibody Immunology Neuroscience

Michael Winklehner , Jan Bauer , Verena Endmayr , Carmen Schwaiger , Gerda Ricken , Masakatsu Motomura , Shunsuke Yoshimura , Hiroshi Shintaku , Kinya Ishikawa , Yukio Tsuura , Takahiro Iizuka , Takanori Yokota , Takashi Irioka , Romana Höftberger ·

YOU? · · 2022 · Open Access · · DOI: https://doi.org/10.1212/nxi.0000000000200006 · OA: W4284881485

Anti-Yo-PCD showed characteristic features of a T cell-mediated pathology, whereas this was not observed in 1 case of anti-P/Q-VGCC-PCD. Our findings support a pathogenic role of anti-P/Q-VGCC autoantibodies in causing neuronal dysfunction, probably due to altered synaptic transmission resulting in calcium dysregulation and subsequent PC death. Because disease progression may lead to irreversible PC loss, anti-P/Q-VGCC-PCD patients could benefit from early oncologic and immunologic therapies.