Parkinson’s Disease Through the Lens of Metabolomics: A Targeted Systematic Review on Human Studies (2019–2024) Article Swipe
F Cannas
,
Karolina Krystyna Kopeć
,
Natalia Zuddas
,
Flaminia Cesare Marincola
,
Giorgio Arcara
,
Michele Loi
,
Michele Mussap
,
Vassilios Fanos
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/jcm14176277
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/jcm14176277
Background: Parkinson’s disease (PD) is a chronic, progressive neurodegenerative disorder characterized by motor and non-motor symptoms. As conventional diagnostic methods are limited in their ability to detect early-stage PD or monitor its progression, there is growing interest in identifying molecular biomarkers with clinical utility. This systematic review synthesizes recent advancements in the application of metabolomics to PD, with a specific focus on human studies published between 2019 and 2024, a period of notable growth in the research area. Methods: Following PRISMA 2020 guidelines, a comprehensive literature search was conducted across major scientific databases. After screening, 16 eligible original studies were selected based on predefined criteria. Key features extracted included study design, biofluid type, analytical platform, statistical approach, and main findings. Results: Consistent metabolic alterations were observed across several biological pathways, including amino acid metabolism, lipid regulation, mitochondrial energy production, oxidative stress, polyamine metabolism, as well as in gut microbiota-derived metabolites. Biofluids analyzed included plasma, serum, cerebrospinal fluid, saliva, urine, and sebum. While plasma and serum remained the most studied matrices, emerging interest in non-invasive fluids such as saliva and sebum reflects their potential in clinical settings. Methodological heterogeneity was noted across studies, particularly in confounder adjustment and study design. Conclusions: Despite certain limitations, the included studies collectively point to the potential of metabolomics in identifying robust diagnostic and prognostic signatures for PD. This review emphasizes the need for longitudinal studies, methodological standardization, and integration with other omics approaches to advance biomarker discovery and support the development of precision medicine strategies for PD.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/jcm14176277
- https://www.mdpi.com/2077-0383/14/17/6277/pdf?version=1757076973
- OA Status
- gold
- References
- 90
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4414014369
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4414014369Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/jcm14176277Digital Object Identifier
- Title
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Parkinson’s Disease Through the Lens of Metabolomics: A Targeted Systematic Review on Human Studies (2019–2024)Work title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-09-05Full publication date if available
- Authors
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F Cannas, Karolina Krystyna Kopeć, Natalia Zuddas, Flaminia Cesare Marincola, Giorgio Arcara, Michele Loi, Michele Mussap, Vassilios FanosList of authors in order
- Landing page
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https://doi.org/10.3390/jcm14176277Publisher landing page
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https://www.mdpi.com/2077-0383/14/17/6277/pdf?version=1757076973Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2077-0383/14/17/6277/pdf?version=1757076973Direct OA link when available
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Medicine, Metabolomics, Disease, Bioinformatics, Intensive care medicine, Pathology, BiologyTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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