PARP12 is required for mitochondrial function maintenance in thermogenic adipocytes Article Swipe
Fan Hu
,
Chang Li
,
Yafen Ye
,
Xuhong Lu
,
Miriayi Alimujiang
,
Ningning Bai
,
Jingjing Sun
,
Xiaojing Ma
,
Xiaohua Li
,
Ying Yang
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1080/21623945.2022.2091206
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1080/21623945.2022.2091206
PARP12 is a member of poly-ADP-ribosyl polymerase (PARPs), which has been characterized for its antiviral function. Yet its physiological implication in adipocytes remains unknown. Here, we report a central function of PARP12 in thermogenic adipocytes. We show that PARP12 is highly expressed in brown adipose tissue and is mainly localized to the mitochondria. Knockdown of PARP12 in vitro reduced UCP1 expression. In parallel, the deficiency of PARP12 reduced mitochondrial respiration in adipocytes, while overexpression of PARP12 reversed these effects.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1080/21623945.2022.2091206
- OA Status
- gold
- Cited By
- 4
- References
- 41
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4289521772
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4289521772Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1080/21623945.2022.2091206Digital Object Identifier
- Title
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PARP12 is required for mitochondrial function maintenance in thermogenic adipocytesWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-08-02Full publication date if available
- Authors
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Fan Hu, Chang Li, Yafen Ye, Xuhong Lu, Miriayi Alimujiang, Ningning Bai, Jingjing Sun, Xiaojing Ma, Xiaohua Li, Ying YangList of authors in order
- Landing page
-
https://doi.org/10.1080/21623945.2022.2091206Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1080/21623945.2022.2091206Direct OA link when available
- Concepts
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Function (biology), Gene knockdown, Mitochondrion, Cell biology, Thermogenesis, Adipose tissue, Brown adipose tissue, Chemistry, In vitro, Biology, Biochemistry, ApoptosisTop concepts (fields/topics) attached by OpenAlex
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4Total citation count in OpenAlex
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2025: 1, 2024: 2, 2023: 1Per-year citation counts (last 5 years)
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41Number of works referenced by this work
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-
10Other works algorithmically related by OpenAlex
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