Pathogen reduction of monkeypox virus in plasma and whole blood using riboflavin and UV light Article Swipe
Izabela Ragan
,
Lindsay Hartson
,
Elizabeth J. Sullivan
,
Richard A. Bowen
,
Raymond P. Goodrich
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0278862
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0278862
Background Monkeypox virus has recently emerged from endemic foci in Africa and, since October 20, 2022, more than 73,000 human infections have been reported by the CDC from over 100 countries that historically have not reported monkeypox cases. The detection of virus in skin lesions, blood, semen, and saliva of infected patients with monkeypox infections raises the potential for disease transmission via routes that have not been previously documented, including by blood and plasma transfusions. Methods for protecting the blood supply against the threats of newly emerging disease agents exist and include Pathogen Reduction Technologies (PRT) which utilize photochemical treatment processes to inactivate pathogens in blood while preserving the integrity of plasma and cellular components. Such methods have been employed broadly for over 15 years, but effectiveness of these methods under routine use conditions against monkeypox virus has not been reported. Study design and methods Monkeypox virus (strain USA_2003) was used to inoculate plasma and whole blood units that were then treated with riboflavin and UV light (Mirasol Pathogen Reduction Technology System, Terumo BCT, Lakewood, CO). The infectious titers of monkeypox virus in the samples before and after riboflavin + UV treatment were determined by plaque assay on Vero cells. Results The levels of spiked virus present in whole blood and plasma samples exceeded 10 3 infectious particles per dose, corresponding to greater than 10 5 DNA copies per mL. Treatment of whole blood and plasma units under standard operating procedures for the Mirasol PRT System resulted in complete inactivation of infectivity to the limits of detection. This is equivalent to a reduction of ≥ 2.86 +/- 0.73 log 10 pfu/mL of infectivity in whole blood and ≥ 3.47 +/-0.19 log 10 pfu/mL of infectivity in plasma under standard operating conditions for those products. Conclusion Based on this data and corresponding studies on infectivity in patients with monkeypox infections, use of Mirasol PRT would be expected to significantly reduce the risk of transfusion transmission of monkeypox.
Related Topics
Concepts
Riboflavin
Monkeypox
Pathogen
Virology
Microbiology
Biology
Food science
Biochemistry
Gene
Recombinant DNA
Vaccinia
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1371/journal.pone.0278862
- https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0278862&type=printable
- OA Status
- gold
- Cited By
- 9
- References
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- Related Works
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- OpenAlex ID
- https://openalex.org/W4317568097
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4317568097Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1371/journal.pone.0278862Digital Object Identifier
- Title
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Pathogen reduction of monkeypox virus in plasma and whole blood using riboflavin and UV lightWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-01-20Full publication date if available
- Authors
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Izabela Ragan, Lindsay Hartson, Elizabeth J. Sullivan, Richard A. Bowen, Raymond P. GoodrichList of authors in order
- Landing page
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https://doi.org/10.1371/journal.pone.0278862Publisher landing page
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0278862&type=printableDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0278862&type=printableDirect OA link when available
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Riboflavin, Monkeypox, Pathogen, Virology, Microbiology, Biology, Food science, Biochemistry, Gene, Recombinant DNA, VacciniaTop concepts (fields/topics) attached by OpenAlex
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9Total citation count in OpenAlex
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2024: 5, 2023: 4Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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