Pathophysiology and management of crush syndrome: A narrative review Article Swipe
Shahnawaz Khan
,
Deepak Neradi
,
Nikhil Unnava
,
Mantu Jain
,
Sujit Kumar Tripathy
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.5312/wjo.v16.i4.104489
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.5312/wjo.v16.i4.104489
BACKGROUND Crush syndrome refers to the traumatic rhabdomyolysis leading to a spectrum of disorders culminating in acute kidney injury. The burden of crush syndrome is high, and mortality can be as high as 20%. The significant bulk of knowledge is from old articles. Over the last 10 years new research has occurred on diagnosis and treatment in animal models. AIM To overview of crush syndrome and discuss the newer advances related to the pathogenesis and management of a patient with crush syndrome. METHODS The search of databases such as MEDLINE, Google Scholar, Web of Science, and EMBASE revealed 8226 articles. A thorough screening culminated in 83 crush syndrome articles included in this study. RESULTS Acute kidney injury in crush syndrome is currently thought to be due to iron retention. The management of crush syndrome has also been updated with antioxidants, and several gases are being used to treat crush syndrome. In the end, treatment of crush syndrome also includes mental, social, and physical rehabilitation for better outcomes. CONCLUSION The outcomes of crush syndrome have significantly improved with the introduction of newer treatment modalities, including antioxidants, hyperbaric oxygen therapy, and comprehensive mental, social, and physical rehabilitation.
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Metadata
- Type
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- en
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- https://doi.org/10.5312/wjo.v16.i4.104489
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All OpenAlex metadata
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https://openalex.org/W4409510236Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.5312/wjo.v16.i4.104489Digital Object Identifier
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Pathophysiology and management of crush syndrome: A narrative reviewWork title
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reviewOpenAlex work type
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enPrimary language
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2025Year of publication
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2025-04-16Full publication date if available
- Authors
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Shahnawaz Khan, Deepak Neradi, Nikhil Unnava, Mantu Jain, Sujit Kumar TripathyList of authors in order
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https://doi.org/10.5312/wjo.v16.i4.104489Publisher landing page
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diamondOpen access status per OpenAlex
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https://doi.org/10.5312/wjo.v16.i4.104489Direct OA link when available
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Crush syndrome, Crush injury, Medicine, Rhabdomyolysis, Intensive care medicine, Rehabilitation, Physical therapy, SurgeryTop concepts (fields/topics) attached by OpenAlex
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4Total citation count in OpenAlex
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2025: 4Per-year citation counts (last 5 years)
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