Patients' experiences of cancer immunotherapy with immune checkpoint inhibitors: A systematic review and thematic synthesis Article Swipe
Tessa Watts
,
Dominic Roche
,
Judit Csontos
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1111/jocn.17154
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1111/jocn.17154
Aim To obtain a deeper understanding of peoples' experiences of cancer treatments with immune checkpoint inhibitors (ICIs). Background ICIs are transforming survival outcomes for many with certain advanced cancers. Given the possibility of unique immune‐related adverse events (irAEs), understanding treatment experiences is crucial to identify support needs and provide safe and effective person‐centred care. Design A systematic review of qualitative research and thematic synthesis. To report this review, the Preferred Reporting Items for Systematic Analysis and Meta Analysis (PRISMA) checklist and Enhancing Transparency in Reporting the Synthesis of Qualitative Research (ENTREQ) guidance have been used. Data Sources MEDLINE, EMBASE, PsycINFO, CINAHL and Web of Science databases were searched in January 2022 for eligible studies published in English from database inception. Review Methods Two reviewers independently screened records, identified papers for inclusion and appraised methodological quality using the Critical Appraisal Skills Programme checklist. Themes were developed using thematic synthesis. Results Eighteen papers were included and three analytical themes developed: immune checkpoint inhibitor treatment decision‐making; the experience and impact of immune checkpoint inhibitor treatments; and appraising and responding to irAEs. Conclusion The synthesis renders visible individuals' unmet information, psychological and practical support needs. It identifies shortcomings in immune checkpoint inhibitor treatment decision‐making processes and highlights the need for healthcare professionals to recognise and sensitively handle individuals' treatment expectations. Individuals' understandings of and responses to irAEs are also illustrated, and attention drawn to patients' concerns about healthcare professionals' checkpoint inhibitor and irAEs knowledge. Implications for Patient Care To sensitively manage treatment expectations and uncertainties, and optimise health outcomes, there are distinct points in treatment trajectories where care and support might require adapting and enhancing. Impact This review addresses people's experiences of immune checkpoint inhibitor treatments. The core findings reveal unmet information, psychological and practical support needs. Insights derived from this review will enhance individuals' experiences and outcomes and healthcare professionals' practice. Patient or Public Contribution No patient or public involvement.
Related Topics
Concepts
CINAHL
PsycINFO
Thematic analysis
Checklist
Critical appraisal
MEDLINE
Medicine
Systematic review
Health care
Qualitative research
Psychology
Nursing
Psychological intervention
Alternative medicine
Pathology
Social science
Political science
Economics
Law
Economic growth
Cognitive psychology
Sociology
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1111/jocn.17154
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jocn.17154
- OA Status
- hybrid
- Cited By
- 4
- References
- 58
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4394617216
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4394617216Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1111/jocn.17154Digital Object Identifier
- Title
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Patients' experiences of cancer immunotherapy with immune checkpoint inhibitors: A systematic review and thematic synthesisWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
-
2024-04-08Full publication date if available
- Authors
-
Tessa Watts, Dominic Roche, Judit CsontosList of authors in order
- Landing page
-
https://doi.org/10.1111/jocn.17154Publisher landing page
- PDF URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jocn.17154Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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hybridOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jocn.17154Direct OA link when available
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CINAHL, PsycINFO, Thematic analysis, Checklist, Critical appraisal, MEDLINE, Medicine, Systematic review, Health care, Qualitative research, Psychology, Nursing, Psychological intervention, Alternative medicine, Pathology, Social science, Political science, Economics, Law, Economic growth, Cognitive psychology, SociologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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4Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2, 2024: 2Per-year citation counts (last 5 years)
- References (count)
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58Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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