Pattern of Regulatory T Cells, Resident Memory T Cells, and Exhausted T Cells in Human Pericardial Fluid Samples of Cardiovascular Patients Article Swipe
Barbara Érsek
,
Júlia Opra
,
Nóra Fekete
,
Mandula Ifju
,
Viktor Molnár
,
Edina Bugyik
,
Éva Pállinger
,
Andrea Székely
,
Tamás Radovits
,
Béla Merkely
,
Edit I. Buzás
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/ijms26209852
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/ijms26209852
This study investigates T cell subsets in pericardial fluid samples obtained from heart transplantation donors, heart transplantation recipients, and coronary artery bypass graft patients. Using flow cytometry, we characterized regulatory T cells (Tregs), tissue-resident memory T cells (Trm), and exhausted T cells based on specific markers. Our results showed significant alterations in the CD4+ and CD8+ T cell subsets, migration (CXCR3, CCR5), and exhaustion markers (PD-1, TIM3) across the groups. Notably, Tregs and Trm cells were enriched in recipients, while markers of T cell exhaustion showed a complex regulation. These findings provide novel insights into the local immune regulation in cardiac disease and transplantation.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms26209852
- https://www.mdpi.com/1422-0067/26/20/9852/pdf?version=1760100313
- OA Status
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- References
- 60
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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Pattern of Regulatory T Cells, Resident Memory T Cells, and Exhausted T Cells in Human Pericardial Fluid Samples of Cardiovascular PatientsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-10-10Full publication date if available
- Authors
-
Barbara Érsek, Júlia Opra, Nóra Fekete, Mandula Ifju, Viktor Molnár, Edina Bugyik, Éva Pállinger, Andrea Székely, Tamás Radovits, Béla Merkely, Edit I. BuzásList of authors in order
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https://doi.org/10.3390/ijms26209852Publisher landing page
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https://www.mdpi.com/1422-0067/26/20/9852/pdf?version=1760100313Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/1422-0067/26/20/9852/pdf?version=1760100313Direct OA link when available
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0Total citation count in OpenAlex
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60Number of works referenced by this work
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