Pausing guides RNA folding to populate transiently stable RNA structures for riboswitch-based transcription regulation Article Swipe
Hannah S. Steinert
,
Florian Sochor
,
Anna Wacker
,
Janina Buck
,
Christina Helmling
,
Fabian Hiller
,
Sara Keyhani
,
J. Noeske
,
S. Kaspar Grimm
,
Martin Rudolph
,
Heiko Keller
,
Rachel A. Mooney
,
Robert Landick
,
Beatrix Suess
,
Boris Fürtig
,
Jens Wöhnert
,
Harald Schwalbe
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.7554/elife.21297
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.7554/elife.21297
In bacteria, the regulation of gene expression by cis-acting transcriptional riboswitches located in the 5'-untranslated regions of messenger RNA requires the temporal synchronization of RNA synthesis and ligand binding-dependent conformational refolding. Ligand binding to the aptamer domain of the riboswitch induces premature termination of the mRNA synthesis of ligand-associated genes due to the coupled formation of 3'-structural elements acting as terminators. To date, there has been no high resolution structural description of the concerted process of synthesis and ligand-induced restructuring of the regulatory RNA element. Here, we show that for the guanine-sensing xpt-pbuX riboswitch from Bacillus subtilis, the conformation of the full-length transcripts is static: it exclusively populates the functional off-state but cannot switch to the on-state, regardless of the presence or absence of ligand. We show that only the combined matching of transcription rates and ligand binding enables transcription intermediates to undergo ligand-dependent conformational refolding.
Related Topics
Concepts
Riboswitch
RNA
Transcription (linguistics)
Biology
Pseudoknot
Cell biology
Ribosomal binding site
Chemistry
Ligand (biochemistry)
Aptamer
Non-coding RNA
Biophysics
Genetics
Gene
Ribosome
Receptor
Philosophy
Linguistics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.7554/elife.21297
- OA Status
- gold
- Cited By
- 70
- References
- 46
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2619670689
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2619670689Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.7554/elife.21297Digital Object Identifier
- Title
-
Pausing guides RNA folding to populate transiently stable RNA structures for riboswitch-based transcription regulationWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2017Year of publication
- Publication date
-
2017-05-25Full publication date if available
- Authors
-
Hannah S. Steinert, Florian Sochor, Anna Wacker, Janina Buck, Christina Helmling, Fabian Hiller, Sara Keyhani, J. Noeske, S. Kaspar Grimm, Martin Rudolph, Heiko Keller, Rachel A. Mooney, Robert Landick, Beatrix Suess, Boris Fürtig, Jens Wöhnert, Harald SchwalbeList of authors in order
- Landing page
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https://doi.org/10.7554/elife.21297Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.7554/elife.21297Direct OA link when available
- Concepts
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Riboswitch, RNA, Transcription (linguistics), Biology, Pseudoknot, Cell biology, Ribosomal binding site, Chemistry, Ligand (biochemistry), Aptamer, Non-coding RNA, Biophysics, Genetics, Gene, Ribosome, Receptor, Philosophy, LinguisticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
70Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 6, 2024: 10, 2023: 4, 2022: 9, 2021: 9Per-year citation counts (last 5 years)
- References (count)
-
46Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| counts_by_year[4].year | 2021 |
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| counts_by_year[5].year | 2020 |
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| counts_by_year[6].year | 2019 |
| counts_by_year[6].cited_by_count | 12 |
| counts_by_year[7].year | 2018 |
| counts_by_year[7].cited_by_count | 10 |
| counts_by_year[8].year | 2017 |
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| publication_date | 2017-05-25 |
| publication_year | 2017 |
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