PCBP1 depletion promotes tumorigenesis through attenuation of p27Kip1 mRNA stability and translation Article Swipe
Hongshun Shi
,
Hui Li
,
Ronghua Yuan
,
Wen Guan
,
Xiaomei Zhang
,
Shaoyang Zhang
,
Wenliang Zhang
,
Fang Tong
,
Li Li
,
Zhihong Song
,
Changwei Wang
,
Shulan Yang
,
Haihe Wang
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1186/s13046-018-0840-1
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1186/s13046-018-0840-1
Our results thereby indicate that loss of PCBP1 expression firstly attenuates p27 expression at post-transcriptional level, and subsequently promotes carcinogenesis. PCBP1 could be used as a diagnostic marker to cancer patients.
Related Topics
Concepts
Carcinogenesis
Translation (biology)
Messenger RNA
Apoptosis
Attenuation
Cell biology
Cancer research
Biology
Physics
Chemistry
Genetics
Cancer
Gene
Optics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1186/s13046-018-0840-1
- https://jeccr.biomedcentral.com/track/pdf/10.1186/s13046-018-0840-1
- OA Status
- gold
- Cited By
- 68
- References
- 70
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2886263444
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2886263444Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1186/s13046-018-0840-1Digital Object Identifier
- Title
-
PCBP1 depletion promotes tumorigenesis through attenuation of p27Kip1 mRNA stability and translationWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2018Year of publication
- Publication date
-
2018-08-07Full publication date if available
- Authors
-
Hongshun Shi, Hui Li, Ronghua Yuan, Wen Guan, Xiaomei Zhang, Shaoyang Zhang, Wenliang Zhang, Fang Tong, Li Li, Zhihong Song, Changwei Wang, Shulan Yang, Haihe WangList of authors in order
- Landing page
-
https://doi.org/10.1186/s13046-018-0840-1Publisher landing page
- PDF URL
-
https://jeccr.biomedcentral.com/track/pdf/10.1186/s13046-018-0840-1Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://jeccr.biomedcentral.com/track/pdf/10.1186/s13046-018-0840-1Direct OA link when available
- Concepts
-
Carcinogenesis, Translation (biology), Messenger RNA, Apoptosis, Attenuation, Cell biology, Cancer research, Biology, Physics, Chemistry, Genetics, Cancer, Gene, OpticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
68Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 6, 2024: 6, 2023: 5, 2022: 22, 2021: 11Per-year citation counts (last 5 years)
- References (count)
-
70Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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